Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

The Small GTPase Rho: Cellular Functions and Signal Transduction

1996 • 404 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.

1996 • 283 citations

Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β

2000 • 273 citations

Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration

1999 • 260 citations

Angiotensin II Activates RhoA in Cardiac Myocytes

1998 • 224 citations

Association of the Myosin-binding Subunit of Myosin Phosphatase and Moesin: Dual Regulation of Moesin Phosphorylation by Rho-associated Kinase and Myosin Phosphatase

1998 • 210 citations

Remodeling Rather Than Neointimal Formation Explains Luminal Narrowing After Deep Vessel Wall Injury

1996 • 210 citations

Regulation of the Association of Adducin with Actin Filaments by Rho-associated Kinase (Rho-kinase) and Myosin Phosphatase

1998 • 209 citations

Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries

2000 • 199 citations

Rho-Kinase Is Involved in Macrophage-Mediated Formation of Coronary Vascular Lesions in Pigs In Vivo

2000 • 193 citations

Restenosis after percutaneous transluminal coronary angioplasty: Have we been aiming at the wrong target?

1995 • 184 citations

Cellular and Molecular Mechanisms of Coronary Artery Spasm

2000 • 171 citations

Enhanced Myosin Light Chain Phosphorylations as a Central Mechanism for Coronary Artery Spasm in a Swine Model With Interleukin-1β

1997 • 153 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

The IL-1 receptor and Rho directly associate to drive cell activation in inflammation

1999 • 139 citations

Endothelial Dysfunction and Collagen Accumulation

1999 • 123 citations

Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs

2000 • 92 citations

Adenovirus-Mediated Transfer of Dominant-Negative Rho-Kinase Induces a Regression of Coronary Arteriosclerosis in Pigs In Vivo

2001 • 92 citations

Inflammatory Cytokines Cause Coronary Arteriosclerosis-Like Changes and Alterations in the Smooth-Muscle Phenotypes in Pigs

1997 • 80 citations

Rebound Vasospasm after Coronary Revascularization in Association with Calcium Antagonist Withdrawal

1984 • 53 citations

Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1 beta in pigs in vivo.

1995 • 42 citations

Endothelial Vasodilator Function Is Preserved at the Spastic/Inflammatory Coronary Lesions in Pigs

1999 • 35 citations

The role of fibroblast growth factor-2 in the vascular effects of interleukin-1β in porcine coronary arteries in vivo

1996 • 17 citations

Tyrosine Kinase Inhibitor Markedly Suppresses the Development of Coronary Lesions Induced by Long-Term Treatment with Platelet-Derived Growth Factor in Pigs In Vivo

1997 • 15 citations