Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Clostridium difficile Colitis

1994 • 1,328 citations

Glucosylation of Rho proteins by Clostridium difficile toxin B

1995 • 1,025 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins

1995 • 478 citations

Rho GTPases and their effector proteins

2000 • 461 citations

Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.

1988 • 398 citations

Effects of Clostridium difficile toxins given intragastrically to animals

1985 • 398 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro.

1995 • 344 citations

Intracellular Staphylococcus aureus Escapes the Endosome and Induces Apoptosis in Epithelial Cells

1998 • 342 citations

Clostridium difficile–Associated Diarrhea

2001 • 339 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

The CLOSTRIDIA molecular biology and pathogenesis

1997 • 277 citations

Large clostridial cytotoxins — a family of glycosyltransferases modifying small GTP-binding proteins

1996 • 250 citations

Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAc

1986 • 242 citations

Rho family GTPases: more than simple switches

2000 • 235 citations

Internalization ofStaphylococcus aureusby Endothelial Cells Induces Apoptosis

1998 • 234 citations

Glucosylation and ADP Ribosylation of Rho Proteins: Effects on Nucleotide Binding, GTPase Activity, and Effector Coupling

1998 • 211 citations

Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation

1996 • 206 citations

Differential effects of Clostridium difficile toxins A and B on rabbit ileum

1987 • 204 citations

Clostridium difficile toxin B disrupts the barrier function of T84 monolayers

1992 • 194 citations

p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

2000 • 192 citations

Inactivation of Ras by Clostridium sordellii Lethal Toxin-catalyzed Glucosylation

1996 • 190 citations

Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosum.

1992 • 169 citations

Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin

1997 • 162 citations

The N-Terminal Part of the Enzyme Component (C2I) of the Binary Clostridium botulinum C2 Toxin Interacts with the Binding Component C2II and Functions as a Carrier System for a Rho ADP-Ribosylating C3-Like Fusion Toxin

1998 • 156 citations

Toxin A of Clostridium difficile binds to the human carbohydrate antigens I, X, and Y

1991 • 154 citations

Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells.

1997 • 149 citations

Clostridium novyi α-Toxin-catalyzed Incorporation of GlcNAc into Rho Subfamily Proteins

1996 • 141 citations

Direct evidence of mast cell involvement in Clostridium difficile toxin a—induced enteritis in mice☆☆☆

1998 • 132 citations

Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.

1991 • 126 citations

Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermis.

1992 • 120 citations

Different Regions of Rho Determine Rho-selective Binding of Different Classes of Rho Target Molecules

1998 • 119 citations

ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility

1991 • 117 citations

C. difficile toxin A increases intestinal permeability and induces Cl- secretion

1990 • 105 citations

Monoglucosylation of RhoA at Threonine 37 Blocks Cytosol-Membrane Cycling

1999 • 98 citations

A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly.

1993 • 96 citations

ADP-ribosylation Factor and Rho Proteins Mediate fMLP-dependent Activation of Phospholipase D in Human Neutrophils

1998 • 94 citations

A Novel C3-like ADP-ribosyltransferase fromStaphylococcus aureus Modifying RhoE and Rnd3

2001 • 91 citations

ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotide

1987 • 89 citations

Functional Consequences of Monoglucosylation of Ha-Ras at Effector Domain Amino Acid Threonine 35

1998 • 86 citations

GTPases in antigen receptor signalling

1998 • 83 citations

Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells.

1996 • 83 citations

Clostridium difficile toxin A and its effects on cells

1991 • 82 citations

Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins

1998 • 80 citations

Bacterial toxins : tools in cell biology and pharmacology

1997 • 71 citations

Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes

1997 • 67 citations

Difference in Protein Substrate Specificity between Hemorrhagic Toxin and Lethal Toxin fromClostridium sordellii

1996 • 67 citations

Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin

2000 • 61 citations

Rho-ADP-ribosylating exoenzyme from Bacillus cereus. Purification, characterization, and identification of the NAD-binding site

1995 • 54 citations

Toxins from anaerobic bacteria: specificity and molecular mechanisms of action

1998 • 51 citations

Effects of Toxin A fromClostridium difficileon Mast Cell Activation and Survival

1998 • 44 citations

Molecular Mode of Action of the Large Clostridial Cytotoxins

2000 • 38 citations

Two different types of ADP-ribosyltransferase C3 from Clostridium botulinum type D lysogenized organisms

1993 • 24 citations

Molecular Biology of the Clostridium difficile Toxins

1997 • 11 citations