Intracellular reactive oxygen species as apparent modulators of heat-shock protein 27 (hsp27) structural organization and phosphorylation in basal and tumour necrosis factor α-treated T47D human carcinoma cells

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′-Dichlorofluorescin

1990 • 869 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells

1994 • 637 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

1993 • 494 citations

A role for oxygen radicals as second messengers

1991 • 494 citations

Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity.

1994 • 493 citations

Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.

1992 • 464 citations

A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein.

1991 • 445 citations

Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock protein.

1988 • 356 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

Characterization and purification of the small 28,000-dalton mammalian heat shock protein.

1987 • 263 citations

Dissociation as a result of phosphorylation of an aggregated form of the small stress protein, hsp27

1994 • 246 citations

Phorbol ester, calcium ionophore, or serum added to quiescent rat embryo fibroblast cells all result in the elevated phosphorylation of two 28,000-dalton mammalian stress proteins.

1985 • 233 citations

Turning on the respiratory burst

1990 • 211 citations

Identification of the phosphorylation sites of the murine small heat shock protein hsp25

1991 • 199 citations

The dephosphorylation of insulin and epidermal growth factor receptors. Role of endosome-associated phosphotyrosine phosphatase(s).

1992 • 134 citations

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.

1994 • 132 citations

Cytoskeleton as a target in menadione‐induced oxidative stress in cultured mammalian cells. I. Biochemical and immunocytochemical features

1990 • 130 citations

Analysis of the resistance to heat and hydrogen peroxide stresses in COS cells transiently expressing wild type or deletion mutants of the Drosophila 27‐kDa heat‐shock protein

1993 • 129 citations

Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.

1993 • 128 citations

Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction.

1993 • 125 citations

Tumor Necrosis Factor Induces the Rapid Phosphorylation of the Mammalian Heat Shock Protein hsp28

1990 • 125 citations

Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78.

1992 • 122 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein

1989 • 117 citations

Stimulation of free radical generation in human leukocytes by various agents including tumor necrosis factor is a calmodulin dependent process

1990 • 117 citations

Tumor Necrosis Factor Signal Transduction

1989 • 114 citations

Tumor necrosis factor‐α induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27, a stress protein that confers cellular resistance to this cytokine

1995 • 114 citations

The serum‐induced phosphorylation of mammalian hsp27 correlates with changes in its intracellular localization and levels of oligomerization

1994 • 114 citations

Nuclear Localization and Phosphorylation of Three 25-Kilodalton Rat Stress Proteins

1984 • 107 citations

Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cells to clastogenic oxidants.

1991 • 104 citations

Induction of HSP27 Phosphorylation and Thermoresistance in Chinese Hamster Cells by Arsenite, Cycloheximide, A23187, and EGTA

1990 • 97 citations

Expression of drosophila's 27 kDa heat shock protein into rodent cells confers thermal resistance

1992 • 93 citations

Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP

1991 • 91 citations

Tumor necrosis factor-α induces the phosphorylation of 28kDa stress proteins in endothelial cells: Possible role in protection against cytotoxicity?

1989 • 87 citations

Heat shock protects WEHI‐164 target cells from the cytolysis by tumor necrosis factors α and β

1989 • 80 citations

Dynamic Changes in the Structure and Intracellular Locale of the Mammalian Low-Molecular-Weight Heat Shock Protein

1988 • 75 citations

The 27,000 daltons stress proteins are phosphorylated by protein kinase C during the tumor promoter-mediated growth inhibition of human mammary carcinoma cells

1988 • 65 citations

MAPKAP kinase 2 is activated by heat shock and TNF‐α: In vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade

1995 • 58 citations

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.

1992 • 52 citations

Cytolysis by tumor necrosis factor is preceded by a rapid and specific dissolution of microfilaments.

1989 • 45 citations

A time‐course study on superoxide generation and protein kinase C activation in human neutrophils

1988 • 41 citations

Effects of calmodulin antagonists and cytochalasins on proliferation and differentiation of human promyelocytic leukemia cell line HL-60.

1985 • 33 citations

Decreased heat‐ and tumor necrosis factor‐mediated hsp28 phosphorylation in thermotolerant Hela cells

1991 • 18 citations