Alleles of the APC gene: An attenuated form of familial polyposis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory.

1983 • 895 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

1987 • 683 citations

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

1992 • 562 citations

Gardner syndrome in a man with an interstitial deletion of 5q

1986 • 458 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5.

1988 • 196 citations

Association between wild type and mutant APC gene products.

1993 • 194 citations

Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.

1992 • 147 citations

Mutational analysis of patients with adenomatous polyposis: identical inactivating mutations in unrelated individuals.

1993 • 139 citations

A CA repeat 30–70 Kb downstream from the adenomatous polyposis coli (APC) gene

1992 • 136 citations

Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.

1993 • 129 citations

Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis

1992 • 112 citations

Hereditary flat adenoma syndrome

1992 • 111 citations

A CA repeat 30 – 70 KB downstream from the adenomatous polyposis coli (APC) gene

1991 • 96 citations

Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.

1993 • 95 citations

Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis.

1992 • 71 citations

The Adenomatous Polyp and the Hereditary Polyposis Syndromes

1988 • 67 citations

Consider the coiled coil

1991 • 49 citations

Suppression with a difference

1991 • 20 citations

Time machine from dust

1992 • 3 citations