APC Genotype, Polyp Number, and Surgical Options in Familial Adenomatous Polyposis

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Alleles of the APC gene: An attenuated form of familial polyposis

1993 • 621 citations

Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.

1992 • 337 citations

Phenotypic variability of familial adenomatous polyposis in 11 unrelated families with identical APC gene mutation

1994 • 172 citations

Rectal cancer risk in older patients with familial adenomatous polyposis and an ileorectal anastomosis: a cause for concern

1992 • 151 citations

Surgical Management of Multiple Polyposis

1970 • 144 citations

Phenotypic expression in familial adenomatous polyposis: partial prediction by mutation analysis.

1994 • 134 citations

Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli

1994 • 125 citations

Colorectal polyp counts and cancer risk in familial adenomatous polyposis

1996 • 123 citations

Rectal cancer risk in patients treated for familial adenomatous polyposis

1992 • 120 citations

Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis

1993 • 110 citations

Colectomy with ileorectal anastomosis for familial adenomatous polyposis: the risk of rectal cancer.

1987 • 54 citations

Management of multiple polyposis of the large bowel

1971 • 45 citations

Factors affecting the risk of rectal cancer following rectum-preserving surgery in patients with familial adenomatous polyposis

1994 • 43 citations

Reliability of Conventional Indications for Common Bile Duct Exploration

1970 • 10 citations