cGMP and Nitric Oxide Modulate Thrombin-Induced Endothelial Permeability

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Radioimmunoassay for Cyclic Nucleotides

1972 • 2,057 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

SK&F 96365, a novel inhibitor of receptor-mediated calcium entry

1990 • 762 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization.

1979 • 727 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes

1991 • 468 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

1989 • 251 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.

1988 • 218 citations

On the Mechanism of Vascular Leakage Caused by Histamine-Type Mediators

1967 • 201 citations

Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium.

1990 • 196 citations

Continuous Monitoring of Nitric Oxide Release from Human Umbilical Vein Endothelial Cells

1993 • 192 citations

Role of phosphodiesterases in the regulation of endothelial permeability in vitro.

1993 • 189 citations

The mechanism of cGMP-induced relaxation in vascular smooth muscle

1985 • 180 citations

Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

1992 • 175 citations

Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro

1983 • 164 citations

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP

1992 • 145 citations

Nitrovasodilators relax arterial smooth muscle by decreasing [Ca2+]i and uncoupling stress from myosin phosphorylation

1992 • 143 citations

Role of Ca2+ and cyclic AMP in the regulation of the production of prostacyclin by the vascular endothelium.

1982 • 140 citations

Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism

1992 • 140 citations

Cyclic GMP stimulates Na+/Ca2+ exchange in vascular smooth muscle cells in primary culture

1991 • 136 citations

Cyclic GMP-dependent protein kinase stimulates the plasmalemmal Ca2+ pump of smooth muscle via phosphorylation of phosphatidylinositol

1988 • 135 citations

Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence

1989 • 135 citations

Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of cAMP

1991 • 127 citations

The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells.

1993 • 122 citations

Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production.

1993 • 118 citations

Cyclic nucleotide-dependent regulation of Mn2+ influx, [Ca2+]i, and arterial smooth muscle relaxation

1992 • 110 citations

Cyclic-GMP-Mediated Decrease in Permeability of Human Umbilical and Pulmonary Artery Endothelial Cell Monolayers

1994 • 96 citations

Stimulation of cyclic GMP production in cultured endothelial cells of the pig by bradykinin, adenosine diphosphate, calcium ionophore A23187 and nitric oxide

1990 • 96 citations

Production of plasminogen activators and inhibitor by serially propagated endothelial cells from adult human blood vessels.

1987 • 96 citations

Cyclic GMP-dependent protein kinase stimulates the plasma membrane Ca2+ pump ATPase of vascular smooth muscle via phosphorylation of a 240-kDa protein.

1991 • 96 citations

Control of systemic capillary leak syndrome with aminophylline and terbutaline

1992 • 96 citations

A teflon culture dish for high-magnification microscopy and measurements in single cells

1985 • 91 citations

LY195115: a potent, selective inhibitor of cyclic nucleotide phosphodiesterase located in the sarcoplasmic reticulum.

1986 • 83 citations

Evidence for endothelial cell-mediated regulation of macromolecular permeability by postcapillary venules.

1986 • 83 citations

Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein

1989 • 83 citations

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.

1993 • 75 citations

Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta.

1992 • 64 citations

Roles of calcium, cyclic nucleotides, and protein kinase C in regulation of endothelial permeability.

1990 • 63 citations

Opposing roles of cyclic AMP in the vascular control of edema formation

1993 • 58 citations

Characterization of an In Vitro Model to Study the Permeability of Human Arterial Endothelial Cell Monolayers

1988 • 57 citations

Passage of low density lipoproteins through monolayers of human arterial endothelial cells. Effects of vasoactive substances in an in vitro model.

1989 • 56 citations

Atrial natriuretic peptide regulation of endothelial permeability is mediated by cGMP

1990 • 52 citations

Atriopeptin inhibition of thrombin-mediated changes in the morphology and permeability of endothelial monolayers.

1989 • 52 citations

Effects of SK&F 94120, an inhibitor of cyclic nucleotide phosphodiesterase type III, on human platelets

1988 • 52 citations

Atrial natriuretic peptide inhibits oxidant-induced increases in endothelial permeability

1991 • 49 citations

The Simultaneous Acute Release of Tissue-Type Plasminogen Activator and von Willebrand Factor in the Perfused Rat Hindleg Region

1990 • 46 citations

Autocrine and paracrine effects of endothelium-derived relaxing factor on intracellular Ca2+ of endothelial cells and vascular smooth muscle cells. Identification by two-dimensional image analysis in coculture.

1992 • 44 citations

Differential effects of <scp>l</scp>‐arginine on the inhibition by N^G‐nitro‐<scp>l</scp>‐arginine methyl ester of basal and agonist‐stimulated EDRF activity

1991 • 42 citations

Modulation of barrier function of bovine aortic and pulmonary artery endothelial cells: dissociation from cytosolic calcium content

1992 • 40 citations

Induction of prostacyclin biosynthesis is closely associated with increased guanosine 3',5'-cyclic monophosphate accumulation in cultured human endothelium.

1986 • 40 citations

Effects of dibutyryl cAMP on pulmonary air embolism-induced lung injury in awake sheep

1987 • 33 citations

Propagation and morphologic phenotypes of human umbilical cord artery endothelial cells.

1986 • 33 citations

Inhibitory Effects of &amp;beta;-Adrenergic Stimulants on Increased Vascular Permeability Caused by Passive Cutaneous Anaphylaxis, Allergic Mediators, and Mediator Releasers in Rats

1989 • 29 citations

Systemic capillary leak syndrome. Preventive treatment with terbutaline.

1988 • 25 citations

Automated measurement of immunogalactosidase reactions with a fluorogenic substrate by the aperture defined microvolume measurement method and its potential application to schistosoma mansoni immunodiagnosis

1980 • 15 citations

A novel two-compartment culture dish allows microscopic evaluation of two different treatments in one cell culture simultaneously

1994 • 10 citations