Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide: The NO-Cyclic GMP Signal Transduction System

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Cyclic guanosine monophosphate as a mediator of vasodilation.

1986 • 811 citations

Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.

1977 • 692 citations

Nitric oxide as a neuronal messenger

1991 • 638 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin.

1978 • 446 citations

Soluble guanylate cyclase purified from bovine lung contains heme and copper

1981 • 328 citations

Evidence for Two Different Forms of Guanylate Cyclase in Rat Heart

1974 • 286 citations

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

1991 • 275 citations

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms.

1986 • 272 citations

Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP.

1983 • 264 citations

Activation of guanylate cyclase from rat liver and other tissues by sodium azide.

1975 • 228 citations

Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.

1977 • 209 citations

Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells.

1990 • 205 citations

Reversible inactivation of guanylate cyclase by mixed disulfide formation.

1981 • 132 citations

Increases in cyclic GMP levels in brain and liver with sodium azide an activator of guanylate cyclase

1975 • 132 citations

L-Arginine identified as an endogenous activator for soluble guanylate cyclase from neuroblastoma cells.

1982 • 131 citations

Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.

1990 • 111 citations

Localization of particulate guanylate cyclase in plasma membranes and microsomes of rat liver.

1975 • 98 citations

Endothelial nitric oxide synthase is myristylated

1992 • 93 citations

Two forms of guanylate cyclase in mammalian tissues and possible mechanisms for their regulation

1975 • 92 citations

Effects of thiols, sugars, and proteins on nitric oxide activation of guanylate cyclase.

1979 • 90 citations

Increased particulate and decreased soluble guanylate cyclase activity in regenerating liver, fetal liver, and hepatoma.

1975 • 80 citations

Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation.

1983 • 80 citations

Purification of soluble guanylate cyclase from rat liver

1979 • 75 citations

Characterization of protein inhibitors of guanylate cyclase activation from rat heart and bovine lung

1978 • 71 citations

Purification and properties of a protein required for sodium azide activation of guanylate cyclase.

1977 • 68 citations

Solubilization of guanylyl cyclase from bovine rod outer segments and effects of lowering Ca2+ and nitro compounds

1991 • 55 citations

Appearance of magnesium guanylate cyclase activity in rat liver with sodium azide activation

1976 • 54 citations

Requirement for a macromolecular factor for sodium azide activation of guanulate cyclase.

1975 • 34 citations

Effects of Nitrovasodilators, Endothelium-dependent Vasodilators, and Atrial Peptides on cGMP

1988 • 34 citations

Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta

1986 • 29 citations

EDRF is an intracellular second messenger and autacoid to regulate cyclic GMP synthesis in many cells.

1990 • 28 citations

Synthesis of adenosine 3′,5′-monophosphate by guanylate cyclase, a new pathway for its formation

1979 • 24 citations

Molecular Mechanisms of Hormone Action

1978 • 14 citations

Subcellular localization and regulation of the enzymes responsible for EDRF synthesis in endothelial cells and N1E-115 neuroblastoma cells

1990 • 13 citations

Mechanisms for Hormonal Regulation of the Different Isoforms of Guanylate Cyclase

1989 • 13 citations

Modulation of the Guanylate Cyclase -cGMP System by Vasodilators and the Role of Free Radicals as Second Messengers

1989 • 12 citations

Molecular Mechanisms of Hormone Action

1989 • 8 citations

Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cyclic Gmp Signal Transduction System

1993 • 8 citations

Deleted Work

1955 • 0 citations