MyoD1 promoter autoregulation is mediated by two proximal E-boxes

Genomic sequencing.

1984 • 8,343 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

1992 • 1,331 citations

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

1989 • 984 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

The essentials of DNA methylation

1992 • 960 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

1992 • 700 citations

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

1992 • 502 citations

Positive autoregulation of the myogenic determination gene MyoD1

1989 • 492 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

Interplay between proliferation and differentiation within the myogenic lineage

1992 • 424 citations

Myogenic cell lineages

1992 • 360 citations

An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

1991 • 352 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

Making muscle in mammals

1992 • 292 citations

MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer

1992 • 290 citations

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor α-subunit gene

1990 • 261 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements

1990 • 224 citations

Paired MyoD-binding sites regulate myosin light chain gene expression.

1991 • 216 citations

Transcriptional regulation of multigene loci: multilevel control

1993 • 187 citations

Direct homeodomain–DNA interaction in the autoregulation of the fushi tarazu gene

1992 • 179 citations

Effect of cell history on response to helix–loop–helix family of myogenic regulators

1990 • 164 citations

DIFFERENTIATION REQUIRES CONTINUOUS ACTIVE CONTROL

1992 • 158 citations

Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.

1990 • 157 citations

HLH forced dimers: Tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id

1993 • 157 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Myogenesis and developmental control genes

1990 • 121 citations

Gene methylation patterns and expression

1993 • 114 citations

Role of Gene Order in Developmental Control of Human γ- and β-Globin Gene Expression

1993 • 107 citations

Regulation of the mouse desmin gene: transactivation by MyoD, myogenin, MRF4 and Myf5

1993 • 104 citations

The interaction of transcription factors with nucleosomal DNA

1992 • 99 citations

Differentiation of two mouse cell lines is associated with hypomethylation of their genomes.

1984 • 96 citations

An E box mediates activation and repression of the acetylcholine receptor delta-subunit gene during myogenesis.

1993 • 89 citations

Autoregulation - a common property of eukaryotic transcription factors?

1989 • 88 citations

Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation.

1984 • 85 citations

The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences.

1992 • 79 citations

How fixed is the differentiated state?

1989 • 75 citations

Muscle cell differentiation

1989 • 70 citations

Mitogenic repression of myogenin autoregulation.

1991 • 64 citations

Differential trans-activation of muscle-specific regulatory elements including the mysosin light chain box by chicken MyoD, myogenin, and MRF4.

1992 • 57 citations

Regulation of Muscle Cell Growth and Differentiation by the Myod Family of Helix-Loop-Helix Proteins

1992 • 56 citations

AP-1 binds to a putative cAMP response element of the MyoD1 promoter and negatively modulates MyoD1 expression in dividing myoblasts.

1994 • 54 citations

Gene structure and transcription in mouse cells with extensively demethylated DNA.

1989 • 47 citations

A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines

1989 • 44 citations

Hemimethylation and hypersensitivity are early events in transcriptional reactivation of human inactive X-linked genes in a hamster x human somatic cell hybrid.

1992 • 35 citations

Differentiation of Two Mouse Cell Lines Is Associated with Hypomethylation of Their Genomes

1984 • 35 citations

Differential trans Activation Associated with the Muscle Regulatory Factors MyoD1, Myogenin, and MRF4

1990 • 34 citations

Characterisation of a genomic clone covering the structural mouse MyoD1 gene and its promoter region

1991 • 30 citations

Transcription control and differentiation: the HLH family, c-myc and C/EBP

1989 • 26 citations

Induction of α-Fetoprotein Synthesis in Differentiating F9 Teratocarcinoma Cells Is Accompanied by a Genome-Wide Loss of DNA Methylation

1984 • 25 citations

Chromatin structure and gene expression

1992 • 25 citations

Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promoter and first exon is linked to expression of the gene

1990 • 23 citations

Methylation of an α-foetoprotein gene intragenic site modulates gene activity

1992 • 16 citations

Potentiation of MyoD1 activity by 5-aza-2'-deoxycytidine.

1990 • 15 citations

Gene Structure and Transcription in Mouse Cells with Extensively Demethylated DNA

1989 • 15 citations

An E Box Mediates Activation and Repression of the Acetylcholine Receptor δ-Subunit Gene during Myogenesis

1993 • 15 citations

Hemimethylation and Hypersensitivity Are Early Events in Transcriptional Reactivation of Human Inactive X-Linked Genes in a Hamster × Human Somatic Cell Hybrid

1992 • 12 citations

Determination genes

1989 • 7 citations