Induction of α-Fetoprotein Synthesis in Differentiating F9 Teratocarcinoma Cells Is Accompanied by a Genome-Wide Loss of DNA Methylation

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Fundamental techniques in virology.

1969 • 1,768 citations

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

1978 • 1,459 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Hormonal induction of differentiation in teratocarcinoma stem cells: Generation of parietal endoderm by retinoic acid and dibutyryl cAMP

1980 • 803 citations

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.

1982 • 575 citations

Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.

1980 • 570 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

1981 • 475 citations

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

1981 • 464 citations

Substrate and sequence specificity of a eukaryotic DNA methylase

1982 • 441 citations

Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.

1981 • 438 citations

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

1983 • 404 citations

MspI, an isoschizomer of HpaII which cleaves both unmethylated and methylated HpaII sites

1978 • 395 citations

Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm

1981 • 384 citations

Transcriptional control of the murine albumin/alpha-fetoprotein locus during development.

1982 • 371 citations

Teratocarcinomas as a model system for the study of embryogenesis and neoplasia

1975 • 361 citations

α-Fetoprotein in Cancer and Fetal Development

1979 • 299 citations

De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.

1982 • 299 citations

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

1983 • 270 citations

DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning.

1981 • 231 citations

Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld.

1982 • 223 citations

Structure and genomic organization of the mouse dihydrofolate reductase gene

1980 • 218 citations

The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.

1981 • 206 citations

Independent mechanisms involved in suppression of the moloney leukemia virus genome during differentiation of murine teratocarcinoma cells

1983 • 205 citations

Mechanism of action of eukaryotic DNA methyltransferase

1982 • 195 citations

Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression

1983 • 187 citations

Neoplastic differentiation: Interaction of simian virus 40 and polyoma virus with murine teratocarcinoma cells in vitro

1975 • 179 citations

Mouse teratocarcinoma cells: Prospects for the study of embryogenesis and neoplasia

1981 • 152 citations

The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin.

1981 • 151 citations

Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides

1978 • 150 citations

Structure and expression in L-cells of a cloned H4 histone gene of the mouse

1981 • 140 citations

alpha-Fetoprotein and albumin genes are in tandem in the mouse genome.

1981 • 127 citations

Undermethylation at the 5′ end of the albumin gene is necessary but not sufficient for albumin production by rat hepatoma cells in culture

1982 • 124 citations

Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of mice

1983 • 123 citations

The inheritance of methylation patterns in vertebrates

1981 • 119 citations

Expression and methylation of the mouse alpha-fetoprotein gene in embryonic, adult, and neoplastic tissues.

1982 • 119 citations

Epithelial layer formation in differentiating aggregates of F9 embryonal carcinoma cells.

1983 • 117 citations

Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells.

1981 • 107 citations

Absence of significant H–2 and β2-microglobulin mRNA expression by mouse embryonal carcinoma cells

1982 • 104 citations

Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement.

1983 • 102 citations

Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious

1983 • 98 citations

F9 embryonal carcinoma cells can differentiate into endoderm-like cells

1978 • 98 citations

Role of laminin in epithelium formation by F9 aggregates.

1983 • 89 citations

Localization of the casein gene family to a single mouse chromosome.

1982 • 88 citations

Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells.

1982 • 88 citations

Expression of H–2, laminin and SV40T and TASA on differentiation of transformed murine teratocarcinoma cells

1980 • 78 citations

Differentiation as a requirement for simian virus 40 gene expression in F-9 embryonal carcinoma cells.

1979 • 74 citations

Murine?-fetoprotein and albumin: Two evolutionarily linked proteins encoded on the same mouse chromosome

1981 • 65 citations

The presence of intervening sequences in the alpha-fetoprotein gene of the mouse.

1979 • 62 citations

Structure of the alpha-fetoprotein gene in the mouse.

1980 • 43 citations

Chapter 2 Isolation of Nuclei from Animal Cells in Culture

1978 • 32 citations

Tunicamycin reversibly inhibits the terminal differentiation of teratocarcinoma stem cells to endoderm

1983 • 26 citations

Effect of 5‐azacytidine treatment on mouse embryonal carcinoma cells

1983 • 13 citations