Hemimethylation and hypersensitivity are early events in transcriptional reactivation of human inactive X-linked genes in a hamster x human somatic cell hybrid.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 655 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation.

1984 • 305 citations

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

1983 • 299 citations

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

1990 • 264 citations

Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive human X chromosomes.

1984 • 226 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

Isolation and Characterization of a Full-Length Expressible cDNA for Human Hypoxanthine Phosphoribosyltransferase

1983 • 222 citations

Mechanism of action of eukaryotic DNA methyltransferase

1982 • 195 citations

Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR.

1991 • 195 citations

Specific protection of methylated CpGs in mammalian nuclei

1989 • 195 citations

Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

1986 • 164 citations

Dynamics of demethylation and activation of the α-actin gene in myoblasts

1990 • 159 citations

Transformation with DNA from 5-azacytidine-reactivated X chromosomes.

1982 • 149 citations

Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine.

1982 • 149 citations

Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes

1985 • 145 citations

Biochemistry and biology of DNA methylation

1986 • 134 citations

Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.

1988 • 119 citations

Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase.

1982 • 117 citations

Derepression of genes on the human inactive X chromosome: Evidence for differences in locus-specific rates of derepression and rates of transfer of active and inactive genes after DNA-mediated transformation

1982 • 110 citations

Isolation of mammalian cell mutants deficient in glucose-6-phosphate dehydrogenase activity: linkage to hypoxanthine phosphoribosyl transferase.

1975 • 96 citations

Chapter 3: Production and Characterization of Mammalian Cells Reversibly Arrested in G1 by Growth in Isoleucine-Deficient Medium

1973 • 95 citations

High-frequency conversion to a "fluffy" developmental phenotype in Aspergillus spp. by 5-azacytidine treatment: evidence for involvement of a single nuclear gene.

1983 • 90 citations

Demethylation of specific sites in the 5' region of the inactive X-linked human phosphoglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression.

1988 • 90 citations

Assembly of an active chromatin structure during replication

1979 • 86 citations

5-Azacytidine-induced reactivation of the human X chromosome-linked PGK1 gene is associated with a large region of cytosine demethylation in the 5' CpG island.

1990 • 74 citations

Genomic sequencing and in vivo footprinting of an expression-specific DNase I-hypersensitive site of avian vitellogenin II promoter reveal a demethylation of a mCpG and a change in specific interactions of proteins with DNA.

1988 • 62 citations

Mammalian X chromosome inactivation: Testing the hypothesis of transcriptional control

1986 • 59 citations

Active X Chromosome DNA is Unmethylated at Eight CCGG Sites Clustered in a Guanine-Plus-Cytosine-Rich Island at the 5′ End of the Gene for Phosphoglycerate Kinase

1986 • 55 citations

X chromosome inactivation of the human TIMP gene

1990 • 51 citations

DNA methylation of two X chromosome genes in female somatic and embryonal carcinoma cells

1991 • 37 citations

Demethylation of Specific Sites in the 5′ Region of the Inactive X-Linked Human Phosphoglycerate Kinase Gene Correlates with the Appearance of Nuclease Sensitivity and Gene Expression

1988 • 33 citations

A two step model for mammalian X-chromosome inactivation.

1985 • 33 citations

Chromatin structure of active and inactive human X chromosomes

1984 • 31 citations

Comparative study of DNase I sensitivity at the X-linked humanHPRT locus

1988 • 28 citations

Genes controlling gp25/30 cell-surface molecules map to chromosomes X and Y and escape X-inactivation.

1985 • 26 citations

High-frequency reactivation of X-linked genes in chinese hamster � human hybrid cells

1987 • 25 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 22 citations

Hemimethylation of DNA prevents chromatin expression.

1990 • 19 citations