Association of β1 Integrin with Focal Adhesion Kinase and Paxillin in Differentiating Schwann Cells

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Signaling through focal adhesion kinase

1999 • 1,169 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve

1979 • 1,034 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Multi‐faceted regulation of cell differentiation by extracellular matrix

1993 • 610 citations

ECM signalling: orchestrating cell behaviour and misbehaviour

1998 • 537 citations

Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

1992 • 453 citations

Evidence that sensory axons are mitogenic for Schwann cells

1975 • 411 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

Differentiation of axon-related Schwann cells in vitro. I. Ascorbic acid regulates basal lamina assembly and myelin formation.

1987 • 393 citations

Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases.

1986 • 355 citations

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

1996 • 347 citations

Characterization of Tyrosine Phosphorylation of Paxillin in Vitro by Focal Adhesion Kinase

1995 • 334 citations

Role of focal adhesion kinase in integrin signaling

1997 • 331 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Signal transduction through integrins: A central role for focal adhesion kinase?

1995 • 273 citations

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

1995 • 273 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

Focal adhesion kinase: at the crossroads of signal transduction

1997 • 260 citations

The cellular interactions of laminin fragments. Cell adhesion correlates with two fragment-specific high affinity binding sites.

1987 • 243 citations

Differentiation of axon-related Schwann cells in vitro: II. Control of myelin formation by basal lamina

1989 • 200 citations

Interactions of basement membrane components

1983 • 200 citations

Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination.

1993 • 189 citations

Molecules in focus Paxillin

1998 • 184 citations

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

1996 • 176 citations

Rapid Induction and Isolation of Focal Adhesion Complexes

1993 • 174 citations

Integrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts vs. focal contacts.

1993 • 165 citations

ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts

1998 • 143 citations

β4 integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent

1994 • 143 citations

Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.

1995 • 137 citations

Serine and Threonine Phosphorylation of the Paxillin LIM Domains Regulates Paxillin Focal Adhesion Localization and Cell Adhesion to Fibronectin

1998 • 136 citations

Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells.

1992 • 136 citations

Schwann cells proliferate but fail to differentiate in defined medium.

1980 • 135 citations

Differential Regulation of Proline-rich Tyrosine Kinase 2/Cell Adhesion Kinase β (PYK2/CAKβ) and pp125FAK by Glutamate and Depolarization in Rat Hippocampus

1996 • 135 citations

Paxillin is a major phosphotyrosine-containing protein during embryonic development.

1991 • 119 citations

Actin Plays a Role in Both Changes in Cell Shape and Gene- Expression Associated with Schwann Cell Myelination

1997 • 117 citations

Anti‐β1 integrin antibody inhibits schwann cell meylination

1994 • 116 citations

.alpha.1.beta.1 Integrin heterodimer functions as a dual laminin/collagen receptor in neural cells

1990 • 109 citations

The Bovine Papillomavirus E6 Protein Binds to the LD Motif Repeats of Paxillin and Blocks Its Interaction with Vinculin and the Focal Adhesion Kinase

1997 • 91 citations

Expression of the integrin α6β4 in peripheral nerves: localization in schwann and perineural cells and different variants of the β4 subunit

1994 • 91 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase Stimulated by Hepatocyte Growth Factor Leads to Mitogen-activated Protein Kinase Activation

1998 • 85 citations

Focal Adhesion Kinase in Rat Central Nervous System

1995 • 82 citations

Transforming growth factor-beta blocks myelination but not ensheathment of axons by Schwann cells in vitro

1995 • 71 citations

Expression of the protein zero myelin gene in axon-related Schwann cells is linked to basal lamina formation

1993 • 66 citations

Differential tyrosine-specific phosphorylation of integrin in Rous sarcoma virus transformed cells with differing transformed phenotypes.

1990 • 55 citations

Localization of focal adhesion kinase in differentiating Schwann cell/neuron cultures

1998 • 24 citations

Potential roles for focal adhesion kinase in development

1999 • 23 citations

Isotopes and a smoking gun

1993 • 4 citations