Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

1995 • 989 citations

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

1999 • 682 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

1998 • 501 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2

1999 • 395 citations

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin

1995 • 393 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

1995 • 341 citations

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1998 • 339 citations

An SH3 Domain-Containing GTPase-Activating Protein for Rho and Cdc42 Associates with Focal Adhesion Kinase

1996 • 337 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration

1999 • 276 citations

Drosophila singed, a fascin homolog, is required for actin bundle formation during oogenesis and bristle extension.

1994 • 258 citations

Activation of a Novel Calcium-dependent Protein-tyrosine Kinase

1996 • 256 citations

FAK Is the Upstream Signal Protein of the Phosphatidylinositol 3-Kinase-Akt Survival Pathway in Hydrogen Peroxide-induced Apoptosis of a Human Glioblastoma Cell Line

1999 • 252 citations

Morphogenesis of Drosophila ovarian ring canals

1994 • 239 citations

Structure and distribution of the Notch protein in developing Drosophila.

1989 • 208 citations

Integrin-mediated signal transduction pathways.

1999 • 163 citations

A novel α integrin subunit associates with β PS and functions in tissue morphogenesis and movement during Drosophila development

1997 • 160 citations

Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)

1998 • 137 citations

A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.

1994 • 134 citations

The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development

1999 • 116 citations

Suppression of Ultraviolet Irradiation-induced Apoptosis by Overexpression of Focal Adhesion Kinase in Madin-Darby Canine Kidney Cells

1999 • 106 citations

Human T and B Lymphocytes Express a Structurally Conserved Focal Adhesion Kinase, pp125^FAK

1993 • 91 citations

Protein tyrosine kinases: Structure, substrate specificity, and drug discovery

1998 • 87 citations

Molecular Analysis and Developmental Expression of the Focal Adhesion Kinase pp125FAK in Xenopus laevis

1995 • 77 citations

DFak56 Is a Novel Drosophila melanogaster Focal Adhesion Kinase

1999 • 47 citations

Cloning and Characterization of Dfak56, a Homolog of Focal Adhesion Kinase, in Drosophila melanogaster

1999 • 35 citations

Role of the PS integrins in Drosophila development

1995 • 16 citations