Regulators and effectors of the ARF GTPases

Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

1999 • 800 citations

Coordinated Polar Localization of Auxin Efflux Carrier PIN1 by GNOM ARF GEF

1999 • 760 citations

ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

1999 • 513 citations

The role of ARF and Rab GTPases in membrane transport

1999 • 496 citations

Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors

2000 • 468 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex

1999 • 441 citations

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

1997 • 405 citations

Ggas

2000 • 399 citations

Molecules in the ARF Orbit

1998 • 346 citations

The ARF1 GTPase-Activating Protein: Zinc Finger Motif and Golgi Complex Localization

1995 • 337 citations

A Family of Proteins with γ-Adaptin and Vhs Domains That Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome

2000 • 323 citations

The yeast phosphatidylinositol-4-OH kinase Pik1 regulates secretion at the Golgi

1999 • 311 citations

Structural and Functional Analysis of the ARF1–ARFGAP Complex Reveals a Role for Coatomer in GTP Hydrolysis

1999 • 301 citations

β ₂ -Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

1998 • 290 citations

A Primer on Vesicle Budding

1999 • 288 citations

EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization

1999 • 281 citations

The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate

1998 • 267 citations

Role for Drs2p, a P-Type Atpase and Potential Aminophospholipid Translocase, in Yeast Late Golgi Function

1999 • 261 citations

A Family of ADP-Ribosylation Factor Effectors That Can Alter Membrane Transport through thetrans-Golgi

2000 • 257 citations

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins

1999 • 221 citations

GTP hydrolysis by arf-1 mediates sorting and concentration of Golgi resident enzymes into functional COP I vesicles

1999 • 213 citations

Gbf1

1999 • 212 citations

The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

2000 • 212 citations

Type I Phosphatidylinositol 4-Phosphate 5-Kinase Directly Interacts with ADP-ribosylation Factor 1 and Is Responsible for Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Golgi Compartment

2000 • 177 citations

Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function

1999 • 176 citations

Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity

2000 • 175 citations

The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1

1997 • 175 citations

Decoding of Sorting Signals by Coatomer through a GTPase Switch in the COPI Coat Complex

2000 • 154 citations

Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1

2000 • 154 citations

GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6

2000 • 153 citations

Adp-Ribosylation Factor 6 and Endocytosis at the Apical Surface of Madin-Darby Canine Kidney Cells

1999 • 150 citations

ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts

1998 • 143 citations

ARF1 Regulates pH-dependent COP Functions in the Early Endocytic Pathway

2000 • 137 citations

Lipid regulators of membrane traffic through the Golgi complex

1999 • 127 citations

Remodeling of the Actin Cytoskeleton Is Coordinately Regulated by Protein Kinase C and the ADP-Ribosylation Factor Nucleotide Exchange Factor ARNO

1998 • 127 citations

A Conserved Domain of the Arabidopsis GNOM Protein Mediates Subunit Interaction and Cyclophilin 5 Binding

2000 • 125 citations

Phosphoinositide-dependent Activation of the ADP-ribosylation Factor GTPase-activating Protein ASAP1

2000 • 125 citations

p200 ARF–GEP1: A Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A

1999 • 121 citations

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex

2000 • 116 citations

ADP-ribosylation Factor 6 as a Target of Guanine Nucleotide Exchange Factor GRP1

1999 • 110 citations

Mechanisms of vesicle formation: Insights from the COP system

1999 • 110 citations

ARF6 Is Required for Growth Factor- and Rac-Mediated Membrane Ruffling in Macrophages at a Stage Distal to Rac Membrane Targeting

1999 • 106 citations

Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta

1999 • 102 citations

Similarities in Function and Gene Structure of Cytohesin-4 and Cytohesin-1, Guanine Nucleotide-exchange Proteins for ADP-ribosylation Factors

2000 • 97 citations

Building a secretory apparatus: role of ARF1/COPI in Golgi biogenesis and maintenance

1998 • 94 citations

Genetic Interactions in Yeast Between Ypt GTPases and Arf Guanine Nucleotide Exchangers

1999 • 88 citations

GBF1: A Novel Golgi-associated BFA-resistant Guanine Nucleotide Exchange Factor That Displays Specificity for ADP-ribosylation Factor 5

1999 • 88 citations

The ADP ribosylation factor nucleotide exchange factor ARNO promotes β-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization

2000 • 85 citations

Role of Coatomer and Phospholipids in GTPase-activating Protein-dependent Hydrolysis of GTP by ADP-ribosylation Factor-1

2000 • 78 citations

Identification of a Plasma Membrane-associated Guanine Nucleotide Exchange Factor for ARF6 in Chromaffin Cells

2000 • 76 citations

ADP-ribosylation factor 1 dependent clathrin-coat assembly on synthetic liposomes

1999 • 73 citations

Dual Interaction of ADP Ribosylation Factor 1 with Sec7 Domain and with Lipid Membranes during Catalysis of Guanine Nucleotide Exchange

1999 • 71 citations

Arf proteins bind to mitotic kinesin-like protein 1 (MKLP1) in a GTP-dependent fashion

1999 • 69 citations

A role for ADP ribosylation factor in the control of cargo uptake during COPI‐coated vesicle biogenesis

1999 • 69 citations

Identification of Arfophilin, a Target Protein for GTP-bound Class II ADP-ribosylation Factors

1999 • 68 citations

Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch

1999 • 67 citations

Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase

2000 • 59 citations

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I

1999 • 58 citations

ADP-ribosylation Factor 6 (ARF6) Defines Two Insulin-regulated Secretory Pathways in Adipocytes

1999 • 58 citations

High-Affinity Binding Of The AP-1 Adaptor Complex to Trans-Golgi Network Membranes Devoid Of Mannose 6-Phosphate Receptors

1999 • 55 citations

GCS1, an Arf Guanosine Triphosphatase-activating Protein inSaccharomyces cerevisiae, Is Required for Normal Actin Cytoskeletal Organization In Vivo and Stimulates Actin Polymerization In Vitro

1999 • 52 citations

Interaction of the PDZ Domain of Human PICK1 with Class I ADP-Ribosylation Factors

2000 • 51 citations

Evidence for a Role for ADP-ribosylation Factor 6 in Insulin-stimulated Glucose Transporter-4 (GLUT4) Trafficking in 3T3-L1 Adipocytes

1999 • 50 citations

The ADP-ribosylation factor GTPase-activating protein GIo3p is involved in ER retrieval

1999 • 46 citations

The KDEL Receptor Regulates a GTPase-activating Protein for ADP-ribosylation Factor 1 by Interacting with Its Non-catalytic Domain

1999 • 45 citations

Sec7p Directs the Transitions Required for Yeast Golgi Biogenesis

2000 • 44 citations

Effects of Activated ADP-ribosylation Factors on Golgi Morphology Require neither Activation of Phospholipase D1 nor Recruitment of Coatomer

2000 • 42 citations

Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase

2000 • 14 citations

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I

1999 • 14 citations

Coatomer Vesicles are not Required for Inhibition of Golgi Transport by G‐Protein Activators

2000 • 10 citations

Studies on the inhibition of endosome fusion by GTPγS-bound ARF

1999 • 9 citations

A Conserved Domain of the Arabidopsis GNOM Protein Mediates Subunit Interaction and Cyclophilin 5 Binding

2000 • 6 citations