Essential fatty acids in early life: structural and functional role

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1994 • 2,176 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function

1984 • 1,616 citations

Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)

1998 • 851 citations

Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements

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1995 • 700 citations

The Effects of Dietary α-Linolenic Acid on the Composition of Nerve Membranes, Enzymatic Activity, Amplitude of Electrophysiological Parameters, Resistance to Poisons and Performance of Learning Tasks in Rats

1989 • 664 citations

The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase.

1991 • 660 citations

Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.

1984 • 653 citations

Cloning, Expression, and Nutritional Regulation of the Mammalian Δ-6 Desaturase

1999 • 616 citations

Effect of Dietary Omega-3 Fatty Acids on Retinal Function of Very-Low-Birth-Weight Neonates

1990 • 581 citations

Infant cerebral cortex phospholipid fatty-acid composition and diet

1992 • 569 citations

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

1998 • 549 citations

A case of human linolenic acid deficiency involving neurological abnormalities

1982 • 529 citations

Are long-chain polyunsaturated fatty acids essential nutrients in infancy?

1995 • 524 citations

Arachidonic acid status correlates with first year growth in preterm infants.

1993 • 518 citations

Visual Acuity and the Essentiality of Docosahexaenoic Acid and Arachidonic Acid in the Diet of Term Infants

1998 • 507 citations

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

1998 • 506 citations

Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants.

1996 • 491 citations

Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration

1992 • 485 citations

Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age

1998 • 474 citations

Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status

1995 • 399 citations

Visual Membranes: Specificity of Fatty Acid Precursors for the Electrical Response to Illumination

1975 • 370 citations

Neurodevelopmental Quotient of Healthy Term Infants at 4 Months and Feeding Practice: The Role of Long-Chain Polyunsaturated Fatty Acids

1995 • 351 citations

Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids.

1992 • 340 citations

A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months

1996 • 337 citations

Biochemistry of essential fatty acids

1981 • 333 citations

Visual Acuity, Erythrocyte Fatty Acid Composition, and Growth in Term Infants Fed Formulas with Long Chain Polyunsaturated Fatty Acids for One Year

1997 • 328 citations

n-3 Polyunsaturated Fatty Acids and Cytokine Production in Health and Disease

1997 • 326 citations

Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia

1996 • 316 citations

Dietary Polyunsaturated Fatty Acid Regulation of Gene Transcription

1994 • 305 citations

Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons.

1996 • 299 citations

ROLE OF LINOLEIC ACID IN INFANT NUTRITION

1963 • 297 citations

The Very Low Birth Weight Premature Infant Is Capable of Synthesizing Arachidonic and Docosahexaenoic Acids from Linoleic and Linolenic Acids

1996 • 294 citations

Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)

1993 • 284 citations

Visual Acuity and Fatty Acid Status of Term Infants Fed Human Milk and Formulas with and without Docosahexaenoate and Arachidonate from Egg Yolk Lecithin1

1996 • 284 citations

A role for phospholipid polyunsaturation in modulating membrane protein function

1996 • 280 citations

The lipids in human milk

1996 • 265 citations

Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants

1997 • 253 citations

Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression.

1991 • 248 citations

Human milk and formula fatty acids

1992 • 238 citations

Role of essential fatty acids in the function of the developing nervous system

1996 • 226 citations

Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids.

1992 • 211 citations

Role of sn-1-saturated,sn-2-polyunsaturated phospholipids in control of membrane receptor conformational equilibrium: effects of cholesterol and acyl chain unsaturation on the metarhodopsin I .tautm. metarhodopsin II equilibrium

1992 • 196 citations

A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months

1996 • 181 citations

Maternal and neonatal essential fatty acid status in phospholipids: an international comparative study

1997 • 181 citations

Essential fatty acid deficiency in an infant receiving prolonged parenteral alimentation

1972 • 177 citations

Estimation of Arachidonic Acid Synthesis in Full Term Neonates Using Natural Variation of 13C Content

1995 • 174 citations

Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants

1997 • 169 citations

Lipid-protein interactions mediate the photochemical function of rhodopsin

1988 • 165 citations

Brain Cell and Tissue Recovery in Rats Made Deficient in n-3 Fatty Acids by Alteration of Dietary Fat

1989 • 161 citations

Developmental quotient at 24 months and fatty acid composition of diet in early infancy: a follow up study

1997 • 158 citations

Perilla Oil Prevents the Excessive Growth of Visceral Adipose Tissue in Rats by Down-Regulating Adipocyte Differentiation ,

1997 • 154 citations

Intermediates in Endogenous Synthesis of C22:6ω3 and C20:4ω6 by Term and Preterm Infants

1997 • 150 citations

The fatty acid composition of skeletal muscle membrane phospholipid: Its relationship with the type of feeding and plasma glucose levels in young children

1998 • 147 citations

Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model

1998 • 147 citations

Role of omega-3 fatty acids in health and disease

1993 • 139 citations

Egg yolk as a source of long-chain polyunsaturated fatty acids in infant feeding

1992 • 139 citations

Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.

1994 • 135 citations

Structural and metabolic requirements for activators of the peroxisome proliferator-activated receptor

1993 • 121 citations

IN VITRO FORMATION OF POLYUNSATURATED FATTY ACIDS BY DESATURATION IN RAT BRAIN: SOME PROPERTIES OF THE ENZYMES IN DEVELOPING BRAIN AND COMPARISONS WITH LIVER¹

1978 • 121 citations

Induction of aP2 gene expression by nonmetabolized long-chain fatty acids.

1992 • 121 citations

MRI evidence that docosahexaenoic acid ethyl ester improves myelination in generalized peroxisomal disorders

1998 • 120 citations

Brain Docosahexaenoate Accretion in Fetal Baboons: Bioequivalence of Dietary α-Linolenic and Docosahexaenoic Acids

1997 • 118 citations

Changes in the polyunsaturated fatty acids of breast milk from mothers of full-term infants over 30 wk of lactation

1995 • 115 citations

Individual Differences in Infancy and Later IQ

1995 • 114 citations

Principles of Perinatal—Neonatal Metabolism

1998 • 111 citations

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library

1997 • 109 citations

Biochemical EFA status of mothers and their neonates after normal pregnancy

1990 • 109 citations

Arachidonic acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin E2 and activation of protein kinase C.

1994 • 108 citations

Antagonistic Effects of Dietary Arachidonic Acid and n-3 Polyunsaturated Fatty Acids

1996 • 104 citations

Prevention and Termination of β-Adrenergic Agonist-Induced Arrhythmias by Free Polyunsaturated Fatty Acids in Neonatal Rat Cardiac Myocytes

1995 • 102 citations

Effect of docosahexaenoic acid on membrane fluidity and function in intact cultured Y-79 retinoblastoma cells

1992 • 94 citations

The relationship of novelty preferences during infancy to later intelligence and later recognition memory

1984 • 87 citations

Biochemical effects of dietary linoleic/α‐linolenic acid ratio in term infants

1996 • 83 citations

Essential fatty acid deficiency and brain development

1982 • 82 citations

Relation between plasma phospholipid saturated fatty acids and hyperinsulinemia

1996 • 81 citations

Microalgae as a source of omega 3 fatty acids.

1995 • 80 citations

Maternal and perinatal long-chain fatty acids: Possible roles in preterm birth

1997 • 79 citations

Regulation of adipose cell differentiation. II. Kinetics of induction of the aP2 gene by fatty acids and modulation by dexamethasone.

1991 • 79 citations

Biological membranes: aberrations in membrane structure and function

1989 • 75 citations

Effects of different polunsaturated fatty acids on growth‐related early gene expression and cell growth

1996 • 75 citations

Are essential fatty acids essential for membrane function?

1986 • 75 citations

Polyunsaturated fatty acids exert antiarrhythmic actions as free acids rather than in phospholipids

1996 • 72 citations

Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture.

1998 • 72 citations

Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells

1984 • 71 citations

Effects of Dietary n‐3 Fatty Acids on the Phospholipid Molecular Species of Monkey Brain

1990 • 71 citations

Post-Golgi Vesicles Cotransport Docosahexaenoyl-Phospholipids and Rhodopsin during Frog Photoreceptor Membrane Biogenesis

1997 • 65 citations

Microalgae as a Source of ?3 Fatty Acids1

2015 • 61 citations

Sudden infant death syndrome: Effect of breast and formula feeding on frontal cortex and brainstem lipid composition

1995 • 57 citations

Structural Homogeneity in Unsaturated Fatty Acids of Marine Lipids. A Review

1964 • 56 citations

The role of arachidonic acid in rat heart cell metabolism

1987 • 56 citations

Nutrition and Gene Expression

1999 • 54 citations

Biological Membranes: Aberrations in Membrane Structure and Function

1989 • 52 citations

Essential fatty acid status of fetal plasma phospholipids: similar to postnatal values obtained at comparable gestational ages

1996 • 50 citations

The effects of exposure to exogenous fatty acids and membrane fatty acid modification on the electrical properties of NG108-15 cells

1985 • 48 citations

Production of eicosapentaenoic acid by a bacterium isolated from mackerel intestines

1990 • 45 citations

Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants

1999 • 43 citations

Age- and Dietary-Related Distributions of Hepatic Arachidonic and Docosahexaenoic Acid in Early Infancy

1995 • 42 citations

Fatty acid transport and metabolism in the feto-placental unit and the role of fatty acid-binding proteins

1997 • 39 citations

Correlation of prostacyclin synthesis by human umbilical artery with status of essential fatty acid

1984 • 39 citations

Possible role of the choroid plexus in the supply of brain tissue with polyunsaturated fatty acids

1997 • 36 citations

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2000 • 33 citations

Comparison between the essential fatty acid status of preterm and full-term infants, measured in umbilical vessel walls

1995 • 31 citations

Specialization in membrane structure and metabolism with respect to polyunsaturated lipids.

1988 • 30 citations

Antiarrhythmic Effects of Fish Oils

2015 • 29 citations

Electrocardiographic Notching in Rats Deficient in Essential Fatty Acids

1963 • 28 citations

Orphans await real purpose in life

1996 • 26 citations

Role of long-chain fatty acids in the postnatal induction of genes coding for liver mitochondrial β-oxidative enzymes

1998 • 24 citations

Dietary n-3 fatty acids in the prevention of lethal cardiac arrhythmias

1997 • 23 citations

Essential fatty acids, pregnancy and pregnancy outcome

1996 • 23 citations

Pitfalls in the design and manufacture of infant formulae

1994 • 16 citations

Lipid Metabolism in the Fetal-Placental Unit

1998 • 13 citations

Development in Infant Nutrition

2021 • 6 citations