Lipid-protein interactions mediate the photochemical function of rhodopsin

Chromatographically homogeneous lecithin from egg phospholipids

1965 • 1,304 citations

Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys.

1986 • 922 citations

The Molecular Basis of Visual Excitation

1968 • 813 citations

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

1974 • 730 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Transphosphatidylation by Phospholipase D

1967 • 563 citations

Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin

1965 • 471 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Visual Membranes: Specificity of Fatty Acid Precursors for the Electrical Response to Illumination

1975 • 370 citations

A Possible Essential Role for Dietary Linolenic Acid in the Development of the Young Rat

1976 • 367 citations

Lipid Polymorphism:The Molecular Basis of Nonbilayer Phases

1985 • 285 citations

Lipid requirements for rhodopsin regenerability

1973 • 250 citations

Interactions between photoexcited rhodopsin and GTP-binding protein: kinetic and stoichiometric analyses from light-scattering changes.

1981 • 247 citations

A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments

1979 • 232 citations

Rhodopsin. Purification and recombination with phospholipids assayed by the metarhodopsin I .far. metarhodopsin II transition

1974 • 214 citations

Trigger and Amplification Mechanisms in Visual Phototransduction

1985 • 196 citations

Effect of lipid composition on the calcium/adenosine 5'-triphosphate coupling ratio of the calcium(2+)-ATPase of sarcoplasmic reticulum

1984 • 193 citations

Light-induced calcium fluxes from outer segment layer of vertebrate retinas

1980 • 190 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Rhodopsin-lipid associations in bovine rod outer segment membranes. Identification of immobilized lipid by spin-labels

1979 • 164 citations

A method for the synthesis of isomerically pure saturated mixed-chain phosphatidylcholines

1981 • 164 citations

Early Receptor Potential: Photoreversible Charge Displacement in Rhodopsin

1967 • 160 citations

Disaturated and dipolyunsaturated phospholipids in the bovine retinal rod outer segment disk membrane

1979 • 160 citations

Evidence that cyclic GMP regulates membrane potential in rod photoreceptors

1979 • 144 citations

Photochemical functionality of rhodopsin-phospholipid recombinant membranes

1977 • 142 citations

Effects of detergents and high pressures upon the metarhodopsin I.dbr.metarhodopsin II equilibrium

1974 • 118 citations

Configurational statistics of acyl chains in polyunsaturated lipid bilayers from deuterium NMR

1987 • 117 citations

Temperature and pH dependence of the metarhodopsin I-metarhodopsin II kinetics and equilibria in bovine rod disk membrane suspensions

1984 • 117 citations

cGMP-dependent cation channel of retinal rod outer segments

1987 • 94 citations

Effects of lipid environment on the light-induced conformational changes of rhodopsin. 1. Absence of metarhodopsin II production in dimyristoylphosphatidylcholine recombinant membranes

1985 • 94 citations

The asymmetric transmembrane distribution of phosphatidylethanolamine, phosphatidylserine, and fatty acids of the bovine retinal rod outer segment disk membrane

1981 • 89 citations

Thermotropic behavior of retinal rod membranes and dispersions of extracted phospholipids

1985 • 82 citations

Organization of rhodopsin in photoreceptor membranes. 2. Transmembrane organization of bovine rhodopsin: evidence from proteolysis and lactoperoxidase-catalyzed iodination of native and reconstituted membranes

1978 • 78 citations

Reversible modulation of rhodopsin photolysis in pure phosphatidylserine membranes

1983 • 68 citations

Retinal rod outer segment lipids form bilayers in the presence and absence of rhodopsin: a ³¹P NMR study

1981 • 53 citations

Biochemical aspects of the visual process. XXXVIII. Effects of lateral aggregation on rhodopsin in phospholipase C-treated photoreceptor membranes

1978 • 42 citations

Rhodopsin-phospholipid interactions: dependence of rate of the meta I to meta II transition on the level of associated disk phospholipid

1981 • 40 citations

A rapid method for the purification of rod outer segment disk membranes

1974 • 38 citations

KINETICS OF RHODOPSIN PHOTOLYSIS INTERMEDIATES IN RETINAL ROD DISK MEMBRANES—I. TEMPERATURE DEPENDENCE OF LUMIRHODOPSIN AND METARHODOPSIN I KINETICS

1981 • 35 citations

Temperature dependence of G-protein activation in photoreceptor membranes. Transient extra metarhodopsin II on bovine disk membranes

1987 • 35 citations

[96] Proton, carbon-13, and phosphorus-31 NMR methods for the investigation of rhodopsin-lipid interactions in retinal rod outer segment membranes

1982 • 32 citations

Sensitive light scattering probe of enzymatic processes in retinal rod photoreceptor membranes

1984 • 32 citations

Purification and characterization of the glycoprotein hormone .alpha.-subunit-like material secreted by HeLa cells

1988 • 13 citations