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Phosphatidylcholine cycle and regulation of phosphatidylcholine biosynthesis by enzyme translocation

Data up to Jan 2025

Published1994
Citations106
References191

Total Citations Per Year

Abstract

References (191)

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Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium.

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Signal transduction via phosphatidylcholine cycles

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The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

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A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix.

1992 • 278 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

Phospholipase A2 enzymes: regulation and inhibition

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Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

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Choline-linked Phosphoglycerides

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Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis

1984 • 228 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis.

1983 • 210 citations

Phosphatidylcholine Metabolism

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Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.

1991 • 202 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

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1988 • 199 citations

The Inhibition of Sugar Transport in Chick Embryo Fibroblasts by Cytochalasin B

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Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets

1991 • 193 citations

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism

1989 • 188 citations

Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly

1990 • 186 citations

Poliovirus increases phosphatidylcholine biosynthesis in HeLa cells by stimulation of the rate-limiting reaction catalyzed by CTP: phosphocholine cytidylyltransferase.

1980 • 174 citations

Proteins associated with cytoplasmic actin

1981 • 169 citations

Regulation of phosphatidylcholine biosynthesis in cultured chick embryonic muscle treated with phospholipase C.

1980 • 160 citations

Channeling of Urea Cycle Intermediates in Situ in Permeabilized Hepatocytes

1989 • 159 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Oleic acid promotes the activation and translocation of phosphatidate phosphohydrolase from the cytosol to particulate fractions of isolated rat hepatocytes

1984 • 153 citations

The purification and characterization of CTP:phosphorylcholine cytidylyltransferase from rat liver.

1986 • 143 citations

Nuclear localization of soluble CTP:phosphocholine cytidylyltransferase.

1993 • 141 citations

Regulation of phosphatidylcholine biosynthesis in mammalian cells. II. Effects of phospholipase C treatment on the activity and subcellular distribution of CTP:phosphocholine cytidylyltransferase in Chinese hamster ovary and LM cell lines.

1983 • 141 citations

Phorbol Ester Stimulates the Hydrolysis of Phosphatidylethanolamine in Leukemic HL-60, NIH 3T3, and Baby Hamster Kidney Cells

1989 • 140 citations

Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies.

1983 • 135 citations

Attenuation of sn-1,2-diacylglycerol second messengers by diacylglycerol kinase. Inhibition by diacylglycerol analogs in vitro and in human platelets.

1986 • 134 citations

Enzyme translocation in the regulation of phosphatidylcholine biosynthesis

1984 • 134 citations

A membrane-bound diacylglycerol kinase that selectively phosphorylates arachidonoyl-diacylglycerol. Distinction from cytosolic diacylglycerol kinase and comparison with the membrane-bound enzyme from Escherichia coli.

1988 • 134 citations

Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.

1991 • 131 citations

Regulation of choline kinase activity and phosphatidylcholine biosynthesis by mitogenic growth factors in 3T3 fibroblasts.

1985 • 128 citations

Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis.

1992 • 126 citations

Sphingosine inhibits the activity of rat liver CTP:phosphocholine cytidylyltransferase.

1990 • 125 citations

1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.

1987 • 124 citations

Membrane-bound CTP: Phosphocholine cytidylyltransferase regulates the rate of phosphatidylcholine synthesis in HeLa cells treated with unsaturated fatty acids

1984 • 122 citations

Fatty Acid Activation and Temperature Perturbation of Rat Brain Microsomal Phospholipase D

1982 • 121 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Receptor-coupled phospholipase D and its inhibition

1991 • 119 citations

Translocation of CTP:phosphocholine cytidylyltransferase from cytosol to membranes in HeLa cells: stimulation by fatty acid, fatty alcohol, mono- and diacylglycerol

1987 • 119 citations

A NEW PHOSPHOLIPIDE-SPLITTING ENZYME SPECIFIC FOR THE ESTER LINKAGE BETWEEN THE NITROGENOUS BASE AND THE PHOSPHORIC ACID GROUPING

1947 • 118 citations

Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.

1988 • 117 citations

cAMP analogues inhibit phosphatidylcholine biosynthesis in cultured rat hepatocytes.

1981 • 117 citations

The diglyceride kinase of rat cerebral cortex

1971 • 115 citations

The role of phosphatidylglycerol in the activation of CTP:phosphocholine cytidylyltransferase from rat lung.

1978 • 115 citations

CTP:phosphorylcholine cytidylyltransferase in rat lung. The effect of free fatty acids on the translocation of activity between microsomes and cytosol.

1984 • 109 citations

Regulation of rat liver cytosolic CTP: phosphocholine cytidylyltransferase by phosphorylation and dephosphorylation.

1982 • 109 citations

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

1992 • 103 citations

The Role of Phospholipids in Stimulating Phosphorylcholine Cytidyltransferase Activity

1966 • 103 citations

Molecular cloning and characterization of the gene encoding cholinephosphate cytidylyltransferase in Saccharomyces cerevisiae

1987 • 101 citations

Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.

1992 • 99 citations

Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.

1982 • 98 citations

Is arachidonic acid a second messenger in signal transduction?

1991 • 98 citations

Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phosoholipase C in mammalian cells

1986 • 97 citations

Lipid requirements for activation of CTP: phosphocholine cytidylyltransferase from rat liver.

1978 • 96 citations

The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymes

1976 • 96 citations

Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a decrease in cellular diacylglycerol levels in cultured rat hepatocytes.

1992 • 95 citations

Regulation of CTP:phosphocholine cytidylyltransferase in HeLa cells. Effect of oleate on phosphorylation and intracellular localization.

1993 • 94 citations

Diacylglycerol signals the translocation of CTP:choline-phosphate cytidylyltransferase in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate.

1991 • 93 citations

Feedback regulation of CTP:phosphocholine cytidylyltransferase translocation between cytosol and endoplasmic reticulum by phosphatidylcholine.

1990 • 93 citations

Activation of Protein Kinase C by Naturally Occurring Ether-linked Diglycerides

1989 • 91 citations

Choline deficiency causes translocation of CTP:phosphocholine cytidylyltransferase from cytosol to endoplasmic reticulum in rat liver.

1990 • 89 citations

Activity and properties of CTP: Cholinephosphate cytidylyltransferase in adult and fetal rat lung

1976 • 88 citations

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine

1990 • 87 citations

Phosphatidylcholine synthesis for incorporation into membranes or for secretion as plasma lipoproteins by Golgi membranes of rat liver.

1987 • 87 citations

Immunolocalization of membrane-associated CTP:phosphocholine cytidylyltransferase in phosphatidylcholine-deficient Chinese hamster ovary cells.

1992 • 82 citations

Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes.

1992 • 82 citations

Evidence that binding of CTP:phosphocholine cytidylyltransferase to membranes in rat hepatocytes is modulated by the ratio of bilayer- to non-bilayer-forming lipids

1993 • 82 citations

Chemical Cross-linking Reveals a Dimeric Structure for CTP: Phosphocholine Cytidylyltransferase

1989 • 82 citations

Regulation of phosphatidylcholine biosynthesis in mammalian cells. I. Effects of phospholipase C treatment on phosphatidylcholine metabolism in Chinese hamster ovary cells and LM mouse fibroblasts.

1983 • 81 citations

Properties of Microsomal and Soluble Diacylglycerol Kinase in Rat Liver

1978 • 81 citations

Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates

1989 • 80 citations

Purification and characterization of CTP: cholinephosphate cytidylytransferase from rat liver cytosol.

1977 • 80 citations

CTP: Phosphocholine Cytidylyltransferase Is a Substrate for cAMP-dependent Protein Kinase in Vitro

1989 • 78 citations

Regulation of CTP:phosphocholine cytidylyltransferase activity and subcellular location by phosphorylation in Chinese hamster ovary cells. The effect of phospholipase C treatment.

1991 • 77 citations

Phorbol esters stimulate phosphatidylcholine biosynthesis by translocation of CTP: Phosphocholine cytidylyltransferase from cytosol to microsomes

1984 • 77 citations

An increase in cytoplasmic CTP accelerates the reaction catalyzed by CTP:phosphocholine cytidylyltransferase in poliovirus-infected HeLa cells.

1980 • 75 citations

Evidence for a protein kinase C‐directed mechanism in the phorbol diester‐induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine

1989 • 74 citations

Regulation of CTP:phosphocholine cytidylyltransferase by lipids. 2. Surface curvature, acyl chain length, and lipid-phase dependence for activation

1991 • 74 citations

Regulation of the translocation of phosphatidate phosphohydrolase between the cytosol and the endoplasmic reticulum of rat liver. Effects of unsaturated fatty acids, spermine, nucleotides, albumin and chlorpromazine

1985 • 72 citations

CTP:phosphorylcholine cytidylyltransferase from rat liver. Isolation and characterization of the catalytic subunit.

1987 • 72 citations

Interactions of insulin, glucagon and dexamethasone in controlling the activity of glycerol phosphate acyltransferase and the activity and subcellular distribution of phosphatidate phosphohydrolase in cultured rat hepatocytes

1985 • 71 citations

Solubilization and properties of a membrane-bound enzyme from rat brain catalyzing a base-exchange reaction

1973 • 70 citations

The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis

1993 • 70 citations

Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes

1992 • 69 citations

Phosphorylation of CTP:phosphocholine cytidylyltransferase in vivo. Lack of effect of phorbol ester treatment in HeLa cells.

1990 • 68 citations

Effects of phorbol ester on phospholipid metabolism

1990 • 67 citations

Colony-stimulating factor 1 regulates CTP: phosphocholine cytidylyltransferase mRNA levels.

1991 • 66 citations

Stimulus-dependent mobilization of protein kinase C

1986 • 60 citations

Control of phosphatidylcholine synthesis in Hep G2 cells. Effect of fatty acids on the activity and immunoreactive content of choline phosphate cytidylyltransferase.

1991 • 59 citations

Effect of cytochalasins on cytosolic-free calcium concentration and phosphoinositide metabolism in leukocytes

1987 • 59 citations

Characterization of cytosolic forms of CTP: choline-phosphate cytidylyltransferase in lung, isolated alveolar type II cells, A549 cell and Hep G2 cells

1989 • 58 citations

Intracellular processing of cytidylyltransferase in Krebs II cells during stimulation of phosphatidylcholine synthesis. Evidence that a plasma membrane modification promotes enzyme translocation specifically to the endoplasmic reticulum.

1988 • 57 citations

Translocation of diacylglycerol kinase in response to chemotactic peptide and phorbol ester in neutrophils

1987 • 54 citations

Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes

1992 • 54 citations

Physiologic 1,2-diacylglycerol levels induce protein kinase C-independent translocation of a regulatory enzyme.

1990 • 53 citations

Regulation of deoxyribonucleotide biosynthesis during in vivo bacteriophage T4 DNA replication. Intrinsic control of synthesis of thymine and 5-hydroxymethylcytosine deoxyribonucleotides at precise ratio found in DNA.

1977 • 52 citations

The stimulation and binding of CTP : Phosphorylcholine cytidylyltransferase by phosphatidylcholine-oleic acid vesicles

1985 • 52 citations

On the mechanism of the okadaic acid-induced inhibition of phosphatidylcholine biosynthesis in isolated rat hepatocytes.

1992 • 52 citations

Thyrotropin-releasing hormone and phorbol esters induce phosphatidylcholine synthesis in GH3 pituitary cells. Evidence for stimulation via protein kinase C.

1987 • 52 citations

Distribution of distinct arachidonoyl-specific and non-specific isoenzymes of diacylglycerol kinase in baboon (Papio cynocephalus) tissues

1990 • 51 citations

Regulation of eukaryotic phospholipid metabolism 1

1991 • 51 citations

Comparison of the lipid regulation of yeast and rat CTP: phosphocholine cytidylyltransferase expressed in COS cells

1992 • 51 citations

Fatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepatocytes

1983 • 49 citations

Lipid requirements for the aggregation of CTP:phosphocholine cytidylyltransferase in rat liver cytosol

1979 • 48 citations

Stimulation of phosphatidylcholine synthesis by fatty acids in fetal rabbit type II pneumocytes

1986 • 47 citations

Binding of CTP:phosphocholine cytidylyltransferase to large unilamellar vesicles

1987 • 47 citations

Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide f-Met-Leu-Phe

1986 • 46 citations

Occurrence of immunoreactive 80 kDa and non-immunoreactive diacylglycerol kinases in different pig tissues.

1988 • 46 citations

Stimulation of cholinephosphate cytidylyltransferase activity by estrogen in fetal rabbit lung is mediated by phospholipids

1985 • 45 citations

The supply of both CDP-choline and diacylglycerol can regulate the rate of phosphatidylcholine synthesis in HeLa cells

1986 • 45 citations

Can phosphorylation of phosphatidate phosphohydrolase by a cyclic AMP-dependent mechanism regulate its activity and subcellular distribution and control hepatic glycerolipid synthesis?

1984 • 45 citations

Phosphatidylcholine metabolism in rat liver after partial hepatectomy. Evidence for increased activity and amount of CTP:phosphocholine cytidylyltransferase

1991 • 44 citations

Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown

1992 • 43 citations

Dynamic spatial distribution of proteins in the cell

1988 • 42 citations

INCORPORATION OF RADIOACTIVE SULFATE SULFUR INTO TAURINE AND OTHER SUBSTANCES IN THE CHICK EMBRYO

1955 • 41 citations

Interleukin 3 stimulates phosphatidylcholine turnover in a mast/megakaryocyte cell line

1989 • 40 citations

Localization of the Membrane-Associated CTP: Phosphocholine Cytidylyltransferase in Chinese Hamster Ovary Cells with an Altered Membrane Composition

1989 • 40 citations

Calcium rather than protein kinase C is the major factor to activate phospholipase D in FMLP-stimulated rabbit peritoneal neutrophils. Possible involvement of calmodulin/myosin L chain kinase pathway.

1992 • 40 citations

Isolation and characterization of a Chinese hamster ovary cell mutant with altered regulation of phosphatidylserine biosynthesis

1989 • 37 citations

Dexamethasone increases the activity but not the amount of choline-phosphate cytidylyltransferase in fetal rat lung

1990 • 36 citations

Activities of the phosphatidylcholine biosynthetic enzymes in rat liver during development

1983 • 36 citations

Effect of diethylstilboestrol on phosphatidylcholine biosynthesis and choline metabolism in the liver of roosters

1981 • 36 citations

Effect of salts on membrane binding and activity of adipocyte phosphatidate phosphohydrolase

1982 • 35 citations

Evidence for the existence of isozymes of choline kinase and their selective induction in 3-methylcholanthrene- or carbon tetrachloride-treated rat liver

1985 • 34 citations

Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes

1988 • 34 citations

Evaluation of possible mechanisms of phorbol ester stimulation of phosphatidylcholine synthesis in HeLa cells

1985 • 33 citations

Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst

1992 • 32 citations

The protein phosphatase inhibitor, okadaic acid, inhibits phosphatidylcholine biosynthesis in isolated rat hepatocytes

1991 • 32 citations

Bimodal distribution of phosphatidic acid phosphohydrolase in NG108–15 cells

1992 • 30 citations

Alterations of phospholipid metabolism by phorbol esters and fatty acids occur by different intracellular mechanisms in cultured glioma, neuroblastoma, and hybrid cells

1989 • 30 citations

Phospholipase activities of rat brain cytosol occurrence of phospholipase c activity with phosphatidylcholine

1982 • 29 citations

Regulation of CTP: phosphocholine cytidylyltransferase activity in type II pneumonocytes

1985 • 28 citations

Expression of Rat CTP:Phosphocholine Cytidylyltransferase in Insect Cells Using a Baculovirus Vector

1993 • 28 citations

Channeling of intermediates in the CDP-choline pathway of phosphatidylcholine biosynthesis in cultured glioma cells is dependent on intracellular Ca2+

1991 • 27 citations

Receptor-coupled phospholipase D: regulation and functional significance

1991 • 26 citations

Activation of a phosphatidylcholine-specific phospholipase C by colony stimulating factor 1 receptor requires tyrosine phosphorylation and a guanine nucleotide-binding protein.

1991 • 26 citations

Cytochalasins induce actin polymerization in human leukocytes

1992 • 25 citations

Pre‐translational regulation by glucocorticoid of fatty acid and phosphatidylcholine synthesis in type II cells from fetal rat lung

1992 • 25 citations

Cytidylyltransferase translocation onto endoplasmic reticulum and increased de novo synthesis without phosphatidylcholine accumulation in Krebs-II ascite cells

1991 • 24 citations

Reversible translocation of cytidylyltransferase between cytosol and endoplasmic reticulum occurs within minutes in whole cells

1992 • 24 citations

Effect of hypoxia on phosphatidylcholine biosynthesis in the isolated hamster heart

1990 • 24 citations

1,2-Diacylglycerols overcome cyclic AMP-mediated inhibition of phosphatidylcholine synthesis in GH3 pituitary cells

1990 • 23 citations

Translocation to rat liver mitochondria of phosphatidate phosphohydrolase

1989 • 23 citations

Modulation of CTP: Phosphocholine cytidylyltransferase translocation by oleic acid and the antitumoral alkylphospholipid in HL-60 cells

1991 • 22 citations

Regulation of phosphatidic acid phosphohydrolase activity during stimulation of human polymorphonuclear leukocytes

1992 • 22 citations

Effect of NaF and okadaic acid on the subcellular distribution of CTP: phosphocoline cytidylyltransferase activity in rat liver

1990 • 21 citations

Influence of cytoskeletal assembly on phosphatidylcholine synthesis in intact phagocytic cells

1980 • 21 citations

Interactions of aminoacyl-tRNA synthetases in high-molecular-weight multienzyme complexes from rat liver

1985 • 21 citations

CTP: Cholinephosphate cytidylyltransferase in human and rat lung: Association in vitro with cytoskeletal actin

1990 • 20 citations

Mechanisms of bombesin-induced arachidonate mobilization in Swiss 3T3 fibroblasts

1991 • 16 citations

Inhibition of phosphatidylcholine and phosphatidylethanolamine biosynthesis by cytochalasin B in cultured glioma cells: Potential regulation of biosynthesis by Ca2+-dependent mechanisms

1991 • 16 citations

Phosphatidylinositol hydrolysis by human plasma phospholipase D

1990 • 15 citations

Phosphatidylcholine Biosynthesis in the Neuroblastoma‐Glioma Hybrid Cell Line NG 108‐15: Stimulation by Phorbol Esters

1986 • 14 citations

Cholecystokinin inhibits phosphatidylcholine synthesis via a Ca(2+)-calmodulin-dependent pathway in isolated rat pancreatic acini. A possible mechanism for diacylglycerol accumulation.

1991 • 13 citations

Stimulation of CTP: phosphocholine cytidylyltransferase and phosphatidylcholine synthesis by incubation of rat hepatocytes with phospholipase A2

1990 • 12 citations

Different susceptibility of alkylacyl - Versus diacyl - and alkenylacyl - phosphatidylcholine subclasses to stimulation of biosynthesis by phospholipase C

1984 • 9 citations

Phorbol myristate acetate stimulates [3H]choline incorporation into phosphatidylcholine independently of the ‘de novo’ pathway in Krebs-II ascitic cells: a unique effect of phorbol ester on choline uptake

1993 • 8 citations

1,2-Diacylglycerol does not mediate the stimulatory effect of phorbol 12-myristate 13-acetate on phosphatidylcholine synthesis in NIH 3T3 fibroblasts

1992 • 7 citations

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