Effects of phorbol ester on phospholipid metabolism

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Enzymac characterization and lipid composition of rat liver subcellular membranes

1971 • 643 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor Promoters

1979 • 594 citations

Elimination of Metabolic Cooperation in Chinese Hamster Cells by a Tumor Promoter

1979 • 559 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Methyl transfering enzyme system of microsomes in the biosynthesis of lecithin (phosphatidylcholine)

1961 • 542 citations

Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.

1987 • 534 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor

1984 • 520 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells.

1987 • 443 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase

1986 • 421 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates.

1975 • 411 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae.

1968 • 376 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Phospholipase A2: Function and pharmacological regulation

1987 • 347 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

Inositol lipids and cell proliferation

1987 • 315 citations

Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the Golgi apparatus en route to the plasma membrane.

1985 • 297 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

The formation of phosphatidylglycerol and other phospholipids by the transferase activity of phospholipase D

1967 • 261 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis

1986 • 244 citations

Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.

1985 • 240 citations

The methylation of phosphatidylethanolamine

1988 • 238 citations

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7

1988 • 236 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid

1986 • 229 citations

The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.

1986 • 228 citations

The base exchange enzymes and phospholipase D of mammalian tissue

1980 • 226 citations

BASE‐EXCHANGE REACTIONS FOR THE SYNTHESIS OF PHOSPHOLIPIDS IN NERVOUS TISSUE: THE INCORPORATION OF SERINE AND ETHANOLAMINE INTO THE PHOSPHOLIPIDS OF ISOLATED BRAIN MICROSOMES^1,2

1971 • 221 citations

Feedback regulation of phospholipase C-beta by protein kinase C.

1990 • 212 citations

1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.

1987 • 211 citations

Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis.

1983 • 210 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Cellular and enzymic synthesis of sphingomyelin

1982 • 193 citations

A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation

1989 • 190 citations

Natural killer cells kill tumour cells at a given stage of differentiation

1981 • 190 citations

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism

1989 • 188 citations

Sphingomyelin is synthesized in the cis Golgi

1990 • 187 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.

1987 • 184 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

The Enzymatic Formation of Sphingomyelin from Ceramide and Lecithin in Mouse Liver

1974 • 179 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.

1986 • 169 citations

Isolation and characterization of subcellular membranes with altered phospholipid composition from cultured fibroblasts.

1976 • 166 citations

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187.

1985 • 163 citations

Studies on the Mechanisms Involved in Multistage Carcinogenesis in Mouse Skin

1982 • 163 citations

Lipid composition and protein profiles of outer and inner membranes from pig heart mitochondria. Comparison with microsomes

1976 • 162 citations

Guanosine 5'-O-thiotriphosphate stimulates phospholipase C activity in plasma membranes of rat hepatocytes.

1985 • 154 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Phosphatidylethanol Biosynthesis in Ethanol-exposed NG108-15 Neuroblastoma X Glioma Hybrid Cells

1989 • 151 citations

Identification and purification of sheep platelet phospholipase A2 isoforms. Activation by physiologic concentrations of calcium ion.

1986 • 147 citations

Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPA

1980 • 147 citations

Stimulation of prostaglandin synthesis by tumor-promoting phorbol-12, 13-diesters in canine kidney (MDCK) cells. Cycloheximide inhibits the stimulated prostaglandin synthesis, deacylation of lipids, and morphological changes

1978 • 142 citations

Phorbol Ester Stimulates the Hydrolysis of Phosphatidylethanolamine in Leukemic HL-60, NIH 3T3, and Baby Hamster Kidney Cells

1989 • 140 citations

Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.

1987 • 140 citations

THE METABOLISM OF LABELLED ETHANOLAMINE IN THE BRAIN OF THE RAT IN VIVO

1967 • 138 citations

Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells.

1981 • 135 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1990 • 134 citations

Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C.

1988 • 131 citations

Negatively charged phospholipids and their position in the cholesterol affinity sequence

1979 • 131 citations

Purification of phosphatidylethanolamine N-methyltransferase from rat liver.

1987 • 130 citations

The p35p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2

1986 • 128 citations

Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C

1987 • 127 citations

Purification of a phospholipase A2 from human monocytic leukemic U937 cells. Calcium-dependent activation and membrane association.

1990 • 125 citations

Sphingosine inhibits the activity of rat liver CTP:phosphocholine cytidylyltransferase.

1990 • 125 citations

Guanine nucleotides stimulate production of inositol trisphosphate in rat cortical membranes

1985 • 125 citations

1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.

1987 • 124 citations

Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. II. Isolation and characterization of phosphatidylserine auxotrophs.

1986 • 122 citations

Growth factors, oncogenes, and multistage carcinogenesis

1987 • 121 citations

Multiple Sources of 1,2-Diacylglycerol in Isolated Rat Pancreatic Acini Stimulated by Cholecystokinin

1989 • 120 citations

Translocation of CTP:phosphocholine cytidylyltransferase from cytosol to membranes in HeLa cells: stimulation by fatty acid, fatty alcohol, mono- and diacylglycerol

1987 • 119 citations

A mutant protein kinase C that can transform fibroblasts

1989 • 119 citations

Protein kinase C-mediated negative-feedback inhibition of unstimulated and bombesin-stimulated polyphosphoinositide hydrolysis in Swiss-mouse 3T3 cells

1987 • 114 citations

Rapid stimulation of phospholipid metabolism in bovine lymphocytes by tumor-promoting phorbol esters.

1978 • 113 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Effects of pertussis toxin treatment on the metabolism of rat adipocytes.

1983 • 112 citations

ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine.

1990 • 110 citations

Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.

1990 • 103 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.

1982 • 98 citations

Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.

1987 • 98 citations

Decreased incidence of gap junctions between Chinese hamster V-79 cells upon exposure to the tumor promoter 12--tetradecanoyl phorbol-13-acetate

1982 • 97 citations

Regulation of phosphatidylcholine biosynthesis in mammalian cells. III. Effects of alterations in the phospholipid compositions of Chinese hamster ovary and LM cells on the activity and distribution of CTP:phosphocholine cytidylyltransferase.

1983 • 95 citations

Phosphatidate as a Molecular Link Between Depolarization and Neurotransmitter Release in the Brain

1981 • 95 citations

Feedback regulation of CTP:phosphocholine cytidylyltransferase translocation between cytosol and endoplasmic reticulum by phosphatidylcholine.

1990 • 93 citations

A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts

1987 • 93 citations

Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5′-[γ-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary to activation of phospholipase C

1990 • 90 citations

Choline deficiency causes translocation of CTP:phosphocholine cytidylyltransferase from cytosol to endoplasmic reticulum in rat liver.

1990 • 89 citations

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid

1989 • 88 citations

Phorbol ester induction of 8-lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema, and oxidant generation but not ornithine decarboxylase induction.

1988 • 87 citations

Second messenger function of phosphatidic acid in platelet activation

1989 • 86 citations

The tumor-enhancing principles of Croton tiglium L.

1965 • 86 citations

Stimulation of choline release from NG108-15 cells by 12-O-tetradecanoylphorbol 13-acetate

1987 • 86 citations

Activation of rat brain protein kinase C by lipid oxidation products

1988 • 83 citations

In vitro protein kinase C phosphorylation sites of placental lipocortin

1988 • 83 citations

The formation of sphingomyelin from phosphatidylcholine in plasma membrane preparations from mouse fibroblasts

1981 • 81 citations

Effects of 12-o-tetradecanoylphorbol 13-acetate on glycerolipid metabolism in cultured myoblasts

1982 • 80 citations

Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: Effect of pertussis toxin, extracellular calcium, and down-regulation of protein kinase C

1988 • 80 citations

Stimulation of choline incorporation in cell cultures by phorbol derivatives and its correlation with their irritant and tumor-promoting activity.

1979 • 78 citations

CTP: Phosphocholine Cytidylyltransferase Is a Substrate for cAMP-dependent Protein Kinase in Vitro

1989 • 78 citations

12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates

1988 • 78 citations

Phorbol esters stimulate phosphatidylcholine biosynthesis by translocation of CTP: Phosphocholine cytidylyltransferase from cytosol to microsomes

1984 • 77 citations

Overexpression of protein kinase C alpha-subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptor numbers for epidermal growth factor.

1990 • 76 citations

Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. III. Genetic evidence for utilization of phosphatidylcholine and phosphatidylethanolamine as precursors.

1986 • 75 citations

Phosphorylation of lipocortins invitro by protein kinase C

1986 • 75 citations

Prostaglandin E and F levels in mouse epidermis are increased by tumor-promoting phorbol esters

1979 • 75 citations

Two-stage tumor promotion in mouse skin: An alternative interpretation

1985 • 75 citations

Evidence for a protein kinase C‐directed mechanism in the phorbol diester‐induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine

1989 • 74 citations

Phorbol 12, myristate 13, acetate potentiates the respiratory burst while inhibits phosphoinositide hydrolysis and calcium mobilization by formyl-methionyl-leucyl-phenylalanine in human neutrophils

1986 • 73 citations

Phorbol ester, 1,2-diacylglycerol, and collagen induce inhibition of arachidonic acid incorporation into phospholipids in human platelets

1989 • 73 citations

Distinction between antigen receptor and IL 2 receptor triggering events in the activation of alloreactive T cell clones with calcium ionophore and phorbol ester.

1985 • 73 citations

Source of arachidonic acid for prostaglandin synthesis in Madin-Darby canine kidney cells.

1981 • 72 citations

Phosphorylation of a chromaffin granule-binding protein by protein kinase C.

1985 • 71 citations

Synergistic release of arachidonic acid from platelets by activators of protein kinase C and calcium ionophores. Evidence for the role of protein phosphorylation in the activation of phospholipase A2 and independence from the sodium/hydrogen ion exchanger

1989 • 71 citations

Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di‐acyl glycerol but not TPA

1990 • 71 citations

Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets

1985 • 70 citations

Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond

1988 • 69 citations

Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations

1986 • 69 citations

Reversal by protein kinase C inhibitor of suppressive actions of phorbol-12-myristate-13-acetate on polyphosphoinositide metabolism and cytosolic Ca2+ mobilization in thrombin-stimulated human platelets

1986 • 69 citations

The phospholipid substrates in the ca2+-stimulated incorporation of nitrogen bases into microsomal phospholipids

1973 • 68 citations

Phosphorylation of CTP:phosphocholine cytidylyltransferase in vivo. Lack of effect of phorbol ester treatment in HeLa cells.

1990 • 68 citations

The role of endogenous phosphatidylcholine and ceramide in the biosynthesis of sphingomyelin in mouse fibroblasts

1982 • 67 citations

Inhibition of intercellular communication by tumor-promoting phorbol esters.

1980 • 66 citations

Differential activation by fMet‐Leu‐Phe and phorbol ester of a plasma membrane phosphatidylcholine‐specific phospholipase D in human neutrophil

1989 • 63 citations

α‐Thrombin‐induced inositol phosphate formation in go‐arrested and cycling hamster lung fibroblasts: Evidence for a protein kinase C‐mediated desensitization response

1986 • 63 citations

Phorbol myristate acetate and the calcium ionophore A23187 synergistically induce release of LTB4 by human neutrophils: involvement of protein kinase C activation in regulation of the 5-lipoxygenase pathway.

1987 • 63 citations

Stimulation of Phospholipase D Activity by Phorbol Esters in Cultured Astrocytes

1990 • 63 citations

Modulation of cell communication and carcinogenesis.

1985 • 62 citations

Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187

1986 • 61 citations

Modes of inhibitory action of protein kinase C in the chemotactic peptide-induced formation of inositol phosphates in differentiated human leukemic (HL-60) cells.

1987 • 60 citations

1,2-dioctanoyl-sn-glycerol can stimulate neutrophils by different mechanisms

1989 • 58 citations

Stimulation of quiescent 3T3 cells by phosphatidic acid-containing liposomes

1987 • 58 citations

The Role of Phosphatidylserine Decarboxylase in Brain Phospholipid Metabolism

1983 • 57 citations

Intracellular processing of cytidylyltransferase in Krebs II cells during stimulation of phosphatidylcholine synthesis. Evidence that a plasma membrane modification promotes enzyme translocation specifically to the endoplasmic reticulum.

1988 • 57 citations

Stimulation of arachidonic acid release by guanine nucleotide in saponin-permeabilized neutrophils: Evidence for involvement of GTP-binding protein in phospholipase A2 activation

1988 • 56 citations

Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells

1989 • 56 citations

IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis.

1988 • 54 citations

Phosphorylation of a chromaffin granule-binding protein in stimulated chromaffin cells.

1986 • 54 citations

The phosphorylcholine acceptor in the phosphatidylcholine: ceramide cholinephosphotransferase reaction is the enzyme a transferase or a hydrolase?

1984 • 52 citations

Bombesin and platelet-derived growth factor stimulate formation of inositol phosphates and Ca2+ mobilization in Swiss 3T3 cells by different mechanisms

1989 • 52 citations

Evidence that phosphatidic acid stimulates the uptake of calcium by liver cells but not calcium release from mitochondria

1981 • 52 citations

Phorbol ester inhibits bradykinin-stimulated inositol trisphosphate formation and calcium mobilization in neuroblastoma x glioma hybrid NG108-15 cells.

1987 • 51 citations

Comparative effects of polymyxin B, phorbol ester and bryostatin on protein phosphorylation, protein kinase C translocation, phospholipid metabolism and differentiation of HL60 cells

1987 • 49 citations

Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: Synergism between diacylglycerol and CA2+ in a protein kinase C-independent mechanism

1987 • 48 citations

Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes

1990 • 47 citations

Two modes of regulation of the phospholipase C-linked substance-P receptor in rat parotid acinar cells

1988 • 44 citations

On the biochemical mechanism of tumorigenesis in mouse skin

1974 • 41 citations

Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.

1987 • 40 citations

Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and β-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate

1986 • 40 citations

Differential actions of phorbol ester and diacylglycerol on inhibition of granulosa cell maturation

1985 • 38 citations

Regulation of the choline, ethanolamine and serine base exchange enzyme activities of rat brain microsomes by phosphorylation and dephosphorylation

1988 • 38 citations

A phospholipase D-like mechanism in pancreatic islet cells: Stimulation by calcium ionophore, phorbol ester and sodium fluoride

1989 • 36 citations

Diacylglycerols, unlike phorbol esters, do not induce homologous desensitization or down-regulation of protein kinase C in Swiss 3T3 cells

1989 • 35 citations

Stimulation of polyphosphoinositide hydrolysis in Swiss 3T3 cells by recombinant fibroblast growth factors

1989 • 35 citations

Carbachol-induced accumulation of inositol-1-phosphate in neurohybridoma NCB-20 cells: Effects of lithium and phorbol esters

1986 • 34 citations

Stimulation of phospholipid hydrolysis and arachidonic acid mobilization in human uterine decidua cells by phorbol ester

1987 • 34 citations

Complementary Oligonucleotide Probe of Vesicular Stomatitus Virus Matrix Protein mRNA Translation

1986 • 34 citations

Phorbol esters activate the pathway for phosphatidylethanol synthesis in differentiating HL-60 cells

1987 • 33 citations

Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), retinoic acid and diazepam on intercellular communication in a monolayer of rat liver epithelial cells

1984 • 32 citations

Protein kinase C catalyses the phosphorylation and activation of rat liver phospholipid methyltransferase

1987 • 31 citations

Phorbol ester activation of phospholipase D in human monocytes but not peripheral blood lymphocytes

1989 • 31 citations

Stimulation of phosphatidylethanolamine synthesis in isolated rat hepatocytes by phorbol 12-myristate 13-acetate

1987 • 31 citations

Alcohols selectively stimulate phospholipase D‐mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 cells

1989 • 30 citations

Stimulation of phosphoinositide metabolism in hamster brown adipocytes exposed to α1-adrenergic agents and its inhibition with phorbol esters

1986 • 30 citations

Compartmentalization and differential labeling of phospholipids of rat liver subcellular membranes

1988 • 30 citations

Regulation of arachidonic acid metabolism in madin-darby canine kidney cells Comparison of A23187 and 12-O-tetradecanoyl-phorbol-13-acetate

1984 • 30 citations

Phosphatidic acid mimicks the muscarinic action of acetylcholine in cultured bovine chromaffin cells

1983 • 28 citations

Phosphatidylcholine hydrolysis stimulated by phorbol myristate acetate is mediated principally by phospholipase D in endothelial cells

1990 • 28 citations

Regulation of CTP: phosphocholine cytidylyltransferase activity in type II pneumonocytes

1985 • 28 citations

Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors

1990 • 28 citations

Mimicry of phorbol ester responses by diacylglycerols. Differential effects on phosphatidylcholine biosynthesis, cell-cell communication and epidermal growth factor binding

1986 • 28 citations

Evidence for a high activity of sphingomyelin biosynthesis by phosphocholine transfer from phosphatidylcholine to ceramides in lung lamellar bodies

1987 • 27 citations

Signals for activation and proliferation of murine T lymphocyte clones.

1987 • 27 citations

Inhibition of foetal pulmonary choline-phosphate cytidylyltransferase under conditions favouring protein phosphorylation

1985 • 27 citations

Phosphatidic acid and arachidonic acid each interact synergistically with glucagon to stimulate Ca2+ influx in the perfused rat liver

1987 • 26 citations

Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b

1987 • 25 citations

Phorbol ester stimulation of sphingomyelin synthesis in human leukemic HL60 cells

1988 • 24 citations

Phorbol ester inhibition of the hormone-stimulated phosphoinositide cycle in WRK-1 cells

1986 • 24 citations

Identification of four lipocortin proteins and phosphorylation of lipocortin I by protein kinase C in cytosols of porcine thyroid cell cultures

1989 • 23 citations

Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells

1988 • 23 citations

1,2‐Dioctanoylglycerol but not 1‐oleoyl‐2‐acetylglycerol inhibits agonist‐induced platelet responses

1987 • 22 citations

Stimulation of phosphatidylcholine synthesis by activators of protein kinase C is dissociable from increased phospholipid hydrolysis

1991 • 22 citations

Synthetic Diacylglycerols Trigger an Increase of Intracellular Free Calcium in Promyelocytic HL60 Cells

1989 • 22 citations

Muscarinic-stimulated Norepinephrine Release and Phosphoinositide Hydrolysis in PC 12 Cells Are Independent Events

1989 • 21 citations

Tumor-promoting phorbol esters stimulate bovine cerebral cortex capillary endothelial cell growth in vitro

1989 • 21 citations

The diacylglycerol analogue, 1,2-sn-dioctanoylglycerol, induces an increase in cytosolic free Ca2+ and cytosolic acidification of T lymphocytes through a protein kinase C-independent process

1989 • 21 citations

Thyrotropin-releasing hormone and phorbol esters stimulate sphingomyelin synthesis in GH3 pituitary cells

1989 • 20 citations

Effect of phorbol ester treatment on receptor-mediated versus G-protein-activator-mediated responses in platelets. Evidence for a two-site action of phorbol ester at the level of G-protein function

1989 • 18 citations

Stimulation of adipocyte phospholipid methyltransferase activity by phorbol 12-myristate 13-acetate. Differential regulation of phospholipid methyltransferase and lipolysis

1987 • 15 citations

Phorbol esters modulate the turnover of both ether- and ester-linked phospholipids in cultured mammalian cells

1990 • 15 citations

Relationship of cellular oncogene expression to inhibition of growth and induction of differentiation of Daudi cells by interferons or TPA

1988 • 15 citations

Phorbol diester synergistically stimulates agonist-induced lipoxygenase product formation in murine macrophages

1986 • 15 citations

Phosphatidylcholine Biosynthesis in the Neuroblastoma‐Glioma Hybrid Cell Line NG 108‐15: Stimulation by Phorbol Esters

1986 • 14 citations

Partial dependency of 1-oleoyl-2-acetyl-glycerol-induced superoxide production by human neutrophils on calcium ions and cytochalasin B

1986 • 13 citations

Phorbol ester stimulates the synthesis of sphingomyelin in NIH 3T3 cells A diminished response in cells transformed with human A‐raf carrying retrovirus

1988 • 13 citations

Differential potentiation of mitogen-stimulated phosphoinositide hydrolysis in protein kinase C-depleted Swiss 3T3 cells

1990 • 13 citations

Diacylglycerols modulate phosphorylation of the insulin receptor from human mononuclear cells

1990 • 11 citations

Lack of phosphorylation of lipocortin I in A431 epidermoid carcinoma cells treated with phorbol esters

1989 • 10 citations

Different susceptibility of alkylacyl - Versus diacyl - and alkenylacyl - phosphatidylcholine subclasses to stimulation of biosynthesis by phospholipase C

1984 • 9 citations

Possible contribution of protein kinase C activation to priming for DNA synthesis induced by epidermal growth factor with insulin and its inhibition by plasma membrane in primary cultured rat hepatocytes

1990 • 8 citations