Receptor-coupled phospholipase D and its inhibition

Inositol phosphates and cell signalling

1989 • 4,058 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

The formation of phosphatidylglycerol and other phospholipids by the transferase activity of phospholipase D

1967 • 261 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes

1988 • 163 citations

The phosphatidylcholine pathway of diacylglycerol formation stimulated by phorbol diesters occurs via phospholipase D activation

1988 • 156 citations

Isolation of human eosinophil phospholipase D.

1976 • 139 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1991 • 118 citations

Purification and characterization of glycosyl-phosphatidylinositol-specific phospholipase D.

1990 • 98 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid

1989 • 88 citations

Microsomal phospholipase D of rat brain and lung tissues

1980 • 81 citations

Tumor necrosis factor-alpha priming of phospholipase A2 activation in human neutrophils. An alternative mechanism of priming.

1991 • 66 citations

Biochemical characterization of phospholipase D activity from human neutrophils

1989 • 55 citations

A novel and sensitive assay for phospholipase D in intact cells

1990 • 54 citations

The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil

1990 • 45 citations

Activation of phospholipase D in rabbit neutrophils by fMet‐Leu‐Phe is mediated by a pertussis toxin‐sensitive GTP‐binding protein that may be distinct from a phospholipase C‐regulating protein

1991 • 38 citations

Phorbol ester activation of phospholipase D in human monocytes but not peripheral blood lymphocytes

1989 • 31 citations

Alcohols selectively stimulate phospholipase D‐mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 cells

1989 • 30 citations

Insufficient Mobilization of Calcium by Early Breakdown of Phosphatidylinositol 4, 5-Bisphosphate for Aggregation of Human Platelets by Collagen1

1985 • 20 citations