The multidrug‐resistance‐reverser verapamil interferes with cellular P‐glycoprotein‐mediated pumping of daunorubicin as a non‐competing substrate

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Mechanism of multidrug resistance

1988 • 630 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Thermodynamics and Control of Biological Free-Energy Transduction

1987 • 403 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Thermodynamics and control of biological free-energy transduction

1988 • 372 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Multidrug Resistance1

1988 • 321 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Cooperativity Theory in Biochemistry

1985 • 280 citations

Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.

1987 • 266 citations

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1983 • 250 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

1989 • 191 citations

Intramitochondrial and Extramitochondrial Concentrations of Adenine Nucleotides and Inorganic Phosphate in Isolated Hepatocytes from Fasted Rats

1978 • 176 citations

Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs.

1990 • 168 citations

Action of calcium antagonists on multidrug resistant cells

1987 • 144 citations

Mechanisms of multidrug resistance in HL60 cells

1989 • 140 citations

P-glycoprotein and multidrug resistance in cancer chemotherapy.

1989 • 139 citations

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

1990 • 122 citations

Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in ehrlich ascites tumour cells

1978 • 121 citations

Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b.

1991 • 113 citations

Induction by verapamil of a rapid increase in ATP consumption in multidrug‐resistant tumor cells

1988 • 109 citations

Kinetics of daunorubicin transport by P‐glycoprotein of intact cancer cells

1992 • 104 citations

Differential transport properties of two mdr gene products are distinguished by progesterone.

1990 • 103 citations

The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor.

1990 • 84 citations

Relationship between Oxygen Uptake of Perifused Rat-Liver Cells and the Cytosolic Phosphorylation State Calculated from Indicator Metabolites and a Redetermined Equilibrium Constant

1978 • 81 citations

P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines

1991 • 79 citations

The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance

1990 • 65 citations

Multidrug resistance and its circumvention

1990 • 54 citations

Immunohistochemical detection of P‐glycoprotein in human tumor cells with a low degree of drug resistance

1989 • 53 citations

Properties of verapamil-hypersensitive multidrug-resistant Chinese hamster ovary cells.

1988 • 46 citations

Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and-sensitive cell lines

1987 • 40 citations

Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient

1990 • 36 citations

Transport of the multidrug resistance modulators verapamil and azidopine in wild type and daunorubicin resistant Ehrlich ascites tumour cells

1990 • 28 citations

In vitro and in vivo modulation of multi‐drug resistance with amiodarone

1991 • 27 citations

A flow-through tissue culture system with fast dynamic response

1982 • 14 citations

Molecular analysis of two human doxorubicin-resistant cell lines: evidence for differing multidrug resistance mechanisms.

1991 • 12 citations