Temporal dynamics of patterning by morphogen gradients

Network motifs: theory and experimental approaches

2007 • 3,170 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

2008 • 714 citations

Probing the Limits to Positional Information

2007 • 698 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

2007 • 602 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning

2004 • 498 citations

Molecular Genetics of Axis Formation in Zebrafish

2005 • 473 citations

Morphogens, their identification and regulation

2004 • 437 citations

Kinetics of Morphogen Gradient Formation

2007 • 398 citations

The Decapentaplegic morphogen gradient: from pattern formation to growth regulation

2007 • 377 citations

On the mechanism of wing size determination in fly development

2007 • 371 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

Canalization of Gene Expression in the Drosophila Blastoderm by Gap Gene Cross Regulation

2009 • 293 citations

Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

2003 • 292 citations

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

2008 • 289 citations

Morphogen Gradient Formation

2009 • 289 citations

Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing

2005 • 288 citations

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

2005 • 270 citations

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

2008 • 239 citations

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

2004 • 223 citations

Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning

2005 • 207 citations

Integration of growth and specification in chick wing digit-patterning

2008 • 206 citations

Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc

1998 • 202 citations

Pre-Steady-State Decoding of the Bicoid Morphogen Gradient

2007 • 200 citations

Morphogens and the Control of Cell Proliferation and Patterning in the Spinal Cord

2007 • 196 citations

Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

2008 • 192 citations

The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila

2005 • 177 citations

The BMP-Binding Protein Crossveinless 2 Is a Short-Range, Concentration-Dependent, Biphasic Modulator of BMP Signaling in Drosophila

2008 • 163 citations

Precision of the Dpp gradient

2008 • 143 citations

A Gene Regulatory Network Subcircuit Drives a Dynamic Pattern of Gene Expression

2007 • 129 citations

Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish

2007 • 126 citations

Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment

2002 • 101 citations

On the dynamic nature of positional information

2006 • 100 citations

A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation

1999 • 90 citations

Visualisation and Quantification of Morphogen Gradient Formation in the Zebrafish

2009 • 85 citations

Morphogen gradients in vertebrate limb development

1999 • 65 citations

Theoretical and experimental approaches to understand morphogen gradients

2008 • 50 citations

Morphogen gradients

2000 • 49 citations

The Decapentaplegic morphogen gradient: a precise definition

2008 • 48 citations

Linear signaling in the Toll-Dorsal pathway ofDrosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset

2002 • 44 citations

Peak levels of BMP in theDrosophilaembryo control target genes by a feed-forward mechanism

2005 • 43 citations