Pre-Steady-State Decoding of the Bicoid Morphogen Gradient

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

The segment polarity network is a robust developmental module

2000 • 1,177 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

1988 • 736 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

Protein Mobility in the Cytoplasm of Escherichia coli

1999 • 610 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

Feedback control of intercellular signalling in development

2000 • 535 citations

Establishment of developmental precision and proportions in the early Drosophila embryo

2002 • 496 citations

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

2002 • 463 citations

Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics

2005 • 445 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing

1997 • 416 citations

GFP and β-Galactosidase Transformation Vectors for Promoter/Enhancer Analysis in Drosophila

2000 • 344 citations

RNA binding and translational suppression by bicoid

1996 • 313 citations

Diffusion of Green Fluorescent Protein in the Aqueous-Phase Lumen of Endoplasmic Reticulum

1999 • 311 citations

Diffusion and scaling during early embryonic pattern formation

2005 • 311 citations

The Drosophila posterior-group gene nanos functions by repressing hunchback activity

1989 • 301 citations

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

1997 • 300 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

2003 • 292 citations

Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins

1998 • 266 citations

From gradients to stripes in Drosophila embryogenesis: filling in the gaps

1996 • 260 citations

Dynamical Analysis of Regulatory Interactions in the Gap Gene System of Drosophila melanogaster

2004 • 258 citations

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo

1990 • 258 citations

The specification of neuronal identity by graded sonic hedgehog signalling

1999 • 252 citations

Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila

1994 • 232 citations

Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos

1989 • 222 citations

Activation of posterior gap gene expression in the Drosophila blastoderm

1995 • 201 citations

Posterior segmentation of the Drosophila embryo in the absence of a maternal posterior organizer gene

1989 • 198 citations

Topology and Robustness in the Drosophila Segment Polarity Network

2004 • 192 citations

Seeing Is Believing

2004 • 179 citations

Formation of the BMP Activity Gradient in the Drosophila Embryo

2005 • 178 citations

Diffusion of injected macromolecules within the cytoplasm of living cells.

1981 • 174 citations

High- and Low-mobility Populations of HP1 in Heterochromatin of Mammalian Cells

2004 • 158 citations

The cytoplasmic matrix: its volume and surface area and the diffusion of molecules through it.

1985 • 156 citations

Model for cooperative control of positional information in Drosophila by bicoid and maternal hunchback

1995 • 155 citations

Krüppel requirement for knirps enhancement reflects overlapping gap gene activities in the Drosophila embryo

1989 • 140 citations

Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element

1995 • 138 citations

Bicoid Determines Sharp and Precise Target Gene Expression in the Drosophila Embryo

2005 • 136 citations

Registration of the expression patterns of Drosophila segmentation genes by two independent methods

2001 • 128 citations

Negative Feedback Mechanisms and Their Roles during Pattern Formation

1999 • 127 citations

Signal dynamics in Sonic hedgehog tissue patterning

2006 • 118 citations

Robust, bistable patterning of the dorsal surface of the Drosophila embryo

2006 • 116 citations

Dual Role of the Drosophila Pattern Gene tailless in Embryonic Termini

1991 • 111 citations

Microtubules are stabilized in confluent epithelial cells but not in fibroblasts.

1990 • 103 citations

Elucidating mechanisms underlying robustness of morphogen gradients

2004 • 101 citations

Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences

1989 • 100 citations

Precise domain specification in the developingDrosophilaembryo

2005 • 93 citations

Autonomous concentration-dependent activation and repression of Krüppel by hunchback in the Drosophila embryo

1994 • 87 citations

Activin as a morphogen in Xenopus mesoderm induction

1999 • 84 citations

Embryonic pattern scaling achieved by oppositely directed morphogen gradients

2006 • 79 citations

Anterior-posterior patterning in the Drosophila embryo

2002 • 65 citations

Morphogen gradients in vertebrate limb development

1999 • 65 citations

Model for the robust establishment of precise proportions in the early Drosophila embryo

2005 • 61 citations

Developmental Regulation of bicoid mRNA Stability Is Mediated by the First 43 Nucleotides of the 3′ Untranslated Region

1998 • 54 citations

Morphogen Gradient from a Noisy Source

2005 • 45 citations

Pattern formation and nuclear divisions are uncoupled in Drosophila segmentation: comparison of spatially discrete and continuous models

2004 • 43 citations

Computational analysis of EGFR inhibition by Argos

2005 • 42 citations

Morphogens: Precise Outputs from a Variable Gradient

2006 • 21 citations