14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf

1996 • 570 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Activation of Raf-1 by 14-3-3 proteins

1994 • 370 citations

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

1993 • 345 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization

1996 • 310 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

Interaction of the Protein Kinase Raf-1 with 14-3-3 Proteins

1994 • 285 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

KSR modulates signal propagation within the MAPK cascade.

1996 • 252 citations

Control of the ERK MAP kinase cascade by Ras and Raf.

1996 • 249 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

1996 • 234 citations

Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.

1994 • 218 citations

14-3-3 Is Not Essential for Raf-1 Function: Identification of Raf-1 Proteins That Are Biologically Activated in a 14-3-3- and Ras-Independent Manner

1995 • 217 citations

Negative Regulation of Raf-1 by Phosphorylation of Serine 621

1996 • 215 citations

The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras

1994 • 202 citations

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.

1994 • 185 citations

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.

1995 • 165 citations

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

1995 • 157 citations

Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

1993 • 150 citations

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

1996 • 140 citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activationin vivoandin vitro

1997 • 140 citations

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.

1996 • 134 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila.

1997 • 130 citations

14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain

1997 • 127 citations

An Intact Raf Zinc Finger Is Required for Optimal Binding to Processed Ras and for Ras-Dependent Raf Activation In Situ

1997 • 120 citations

Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger

1997 • 117 citations

A novel role for RhoGDI as an inhibitor of GAP proteins.

1993 • 117 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.

1997 • 95 citations

Identification of the 14.3.3 ζ Domains Important for Self-association and Raf Binding

1995 • 93 citations

Physical Association with Ras Enhances Activation of Membrane-bound Raf (RafCAAX)

1997 • 88 citations

Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation

1997 • 70 citations

Plasma Membrane-Targeted ras GTPase-Activating Protein Is a Potent Suppressor of p21^ras Function

1993 • 67 citations

Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras.

1994 • 55 citations

Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo

1997 • 50 citations

Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells.

1995 • 35 citations

Sequential Modification of Serines 621 and 624 in the Raf-1 Carboxyl Terminus Produces Alterations in Its Electrophoretic Mobility

1997 • 24 citations

The Activity of D-raf in Torso Signal Transduction Is Altered by Serine Substitution, N-Terminal Deletion, and Membrane Targeting

1996 • 22 citations

Inhibition of Raf/MAPK Signaling inXenopusOocyte Extracts by Raf-1-Specific Peptides

1996 • 7 citations