Retinoid X Receptor-Specific Ligands Synergistically Upregulate 1, 25-Dihydroxyvitamin D3-Dependent Transcription in Epidermal Keratinocytes In Vitro and In Vivo

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

1988 • 961 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

1992 • 583 citations

Two nuclear signalling pathways for vitamin D

1993 • 559 citations

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1994 • 432 citations

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

1991 • 421 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

1994 • 354 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

1993 • 305 citations

Vitamin D, Calcium, and Epidermal Differentiation*

1993 • 287 citations

Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene.

1993 • 272 citations

Cloning and expression of cDNA encoding 25‐hydroxyvitamin D₃ 24‐hydroxylase

1991 • 232 citations

Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene.

1994 • 231 citations

Retinoic Acid Receptor Gene Expression in Human Skin

1991 • 212 citations

Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

1995 • 212 citations

Two Vitamin D Response Elements Function in the Rat 1,25-Dihydroxyvitamin D 24-Hydroxylase Promoter

1995 • 190 citations

Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1 alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine.

1992 • 186 citations

Ligand Modulates the Conversion of DNA-Bound Vitamin D₃ Receptor (VDR) Homodimers into VDR-Retinoid X Receptor Heterodimers

1994 • 182 citations

Interaction between retinoic acid and vitamin D signaling pathways.

1993 • 171 citations

Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene.

1994 • 164 citations

Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA.

1993 • 144 citations

Natural Vitamin D₃ Response Elements Formed by Inverted Palindromes: Polarity-Directed Ligand Sensitivity of Vitamin D₃ Receptor-Retinoid X Receptor Heterodimer-Mediated Transactivation

1995 • 139 citations

Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers.

1994 • 137 citations

Retinoic acid receptor gamma: specific immunodetection and phosphorylation.

1991 • 121 citations

Decreased Cyclic AMP in the Epidermis of Lesions of Psoriasis

1972 • 113 citations

Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D response elements by thyroid hormone.

1994 • 107 citations

Mouse Retinoid X Receptor Contains a Separable Ligand-Binding and Transactivation Domain in Its E Region

1995 • 95 citations

Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

1995 • 90 citations

Selective Synthetic Ligands for Human Nuclear Retinoic Acid Receptors

1992 • 84 citations

Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements.

1994 • 66 citations

Identification of a vitamin D responsive element in the promoter of the rat cytochrome P450₂₄gene

1994 • 65 citations

Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives.

1994 • 61 citations

Molecular Biology of Vitamin D Action

1994 • 58 citations

Expression of 25‐hydroxyvitamin D 24‐hydroxylase cytochrome P450 in kidney and intestine Effect of 1,25‐dihydroxyvitamin D and age

1991 • 54 citations

Regulation of messenger ribonucleic acid expression of 1 alpha,25-dihydroxyvitamin D3-24-hydroxylase in rat osteoblasts.

1994 • 53 citations

Transcriptional Activity of a Fluorinated Vitamin D Analog on VDR-RXR-Mediated Gene Expression

1995 • 51 citations

The Retinoid X Receptor Agonist 9-cis-Retinoic Acid and the 24-Hydroxylase Inhibitor Ketoconazole Increase Activity of 1,25-Dihydroxyvitamin D3 in Human Skin In Vivo

1997 • 46 citations

Expression of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA in Cultured Human Keratinocytes

1994 • 37 citations