Molecular Biology of Vitamin D Action

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

Prediction of bone density from vitamin D receptor alleles

1994 • 1,931 citations

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

1978 • 1,624 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Unique Biosynthesis by Kidney of a Biologically Active Vitamin D Metabolite

1970 • 1,281 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

1,25-Dihydroxyvitamin D ₃ Receptors in Human Leukocytes

1983 • 1,030 citations

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

1981 • 1,025 citations

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

1988 • 961 citations

Photosynthesis of Previtamin D ₃ in Human Skin and the Physiologic Consequences

1980 • 742 citations

Target Cells for 1,25-Dihydroxyvitamin D ₃ in Intestinal Tract, Stomach, Kidney, Skin, Pituitary, and Parathyroid

1979 • 713 citations

Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxy-cholecalciferol in uremic patients.

1984 • 689 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D₃IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION

1983 • 600 citations

Expression of cellular homologues of retroviral onc genes in human hematopoietic cells.

1982 • 570 citations

The Nature and Significance of Osteopontin

1989 • 561 citations

25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3

1968 • 550 citations

1,25-Dihydroxyvitamin D ₃ : a Novel Immunoregulatory Hormone

1984 • 536 citations

The vitamin D story: a collaborative effort of basic science and clinical medicine ¹

1988 • 531 citations

Molecular Cloning of Complementary DNA Encoding the Avian Receptor for Vitamin D

1987 • 516 citations

1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.

1980 • 503 citations

Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine

1971 • 501 citations

Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite

1983 • 500 citations

1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells.

1984 • 493 citations

Point mutations in the Human Vitamin D Receptor Gene Associated with Hypocalcemic Rickets

1988 • 490 citations

MINIREVIEW: The Steroid Receptor Superfamily: More Excitement Predicted for the Future

1990 • 489 citations

1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis.

1991 • 475 citations

Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol).

1984 • 471 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells.

1984 • 461 citations

1α,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells

1981 • 460 citations

STUDIES ON EXPERIMENTAL RICKETS

1922 • 454 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

VITAMIN D: RECENT ADVANCES

1983 • 437 citations

Role of Vitamin D in Skeletal Muscle Function*

1986 • 437 citations

Vitamin D-Dependent Calcium Binding Proteins: Chemistry, Distribution, Functional Considerations, and Molecular Biology*

1989 • 428 citations

Pathogenesis of Hereditary Vitamin-D-Dependent Rickets

1973 • 426 citations

Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.

1983 • 424 citations

Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.

1989 • 409 citations

1α,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60)

1982 • 398 citations

Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

1992 • 395 citations

Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression.

1989 • 372 citations

Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA.

1987 • 365 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo

1988 • 365 citations

Vitamin D Receptors: Nature and Function

1986 • 362 citations

Close link between reduction of c-myc expression by interferon and G0/G1 arrest

1985 • 358 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris

1991 • 353 citations

Vitamin-D-Dependent Rickets Type II

1978 • 340 citations

1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro.

1985 • 336 citations

Osteocalcin. Biochemical considerations and clinical applications

1988 • 328 citations

DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.

1990 • 322 citations

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

1994 • 320 citations

The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer.

1990 • 313 citations

Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3.

1987 • 312 citations

1,25-dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukaemia (HL60) cells and induces monocyte-macrophage differentiation in HL60 and normal human bone marrow cells

1983 • 307 citations

Biologically active metabolite of vitamin D3 from bone, liver, and blood serum

1966 • 306 citations

The Association of a Metabolite of Vitamin D3 with Intestinal Mucosa Chromatin in Vivo

1968 • 305 citations

Immunomodulatory role of 1,25‐dihydroxyvitamin D₃

1992 • 302 citations

The effect of 1,25(OH)2D3 on alkaline phosphatase in osteoblastic osteosarcoma cells.

1982 • 300 citations

Heilung von Rachitis durch künstliche Höhensonne

1919 • 299 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Expression of the c-fms proto-oncogene during human monocytic differentiation

1985 • 288 citations

1α,25-Dihydroxycholecalciferol Receptors in Intestine

1974 • 279 citations

Vitamin D3 Receptors: Structure and Function in Transcription

1991 • 271 citations

Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone.

1986 • 260 citations

FAT-SOLUBLE VITAMINS

1924 • 250 citations

The Response of Intestinal Calcium Transport to 25-Hydroxy and 1,25-Dihydroxy Vitamin D in Nephrectomized Rats

1972 • 241 citations

Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

1984 • 236 citations

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

1991 • 233 citations

Cloning and expression of cDNA encoding 25‐hydroxyvitamin D₃ 24‐hydroxylase

1991 • 232 citations

Vitamin D. Gene Regulation, Structure-Function Analysis and Clinical Application

1991 • 230 citations

Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization.

1992 • 224 citations

Brain Target Sites for 1,25-Dihydroxyvitamin D ₃

1982 • 224 citations

Effect of Vitamin D Deficiency on Fertility and Reproductive Capacity in the Female Rat

1980 • 217 citations

1α,25-Dihyroxyvitamin D3 induces differentiation of human promyelocytic leukemia cells (HL-60) into monocyte-macrophages, but not into granulocytes

1983 • 206 citations

AN EXPERIMENTAL INVESTIGATION ON RICKETS

2009 • 204 citations

THE RELATIONSHIP BETWEEN VITAMIN D AND PARATHYROID HORMONE*

1963 • 200 citations

Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3.

1990 • 197 citations

Immunocytochemical Localization of the 1,25-Dihydroxyvitamin D₃Receptor in Target Cells*

1988 • 197 citations

1,25-Dihydroxyvitamin D3 stimulates the alkaline phosphatase activity of osteoblast-like cells.

1981 • 195 citations

Identification of a 1,25-dihydroxyvitamin D3-response element in the 5'-flanking region of the rat calbindin D-9k gene.

1992 • 191 citations

The Government's Present Line on Cardiac Transplantation

1984 • 190 citations

Characterization of the rat osteocalcin gene: stimulation of promoter activity by 1,25-dihydroxyvitamin D3

1988 • 189 citations

Metabolism of vitamin D. A new cholecalciferol metabolite, involving loss of hydrogen at C-1, in chick intestinal nuclei

1969 • 185 citations

Cytoplasmic and nuclear binding components for 1alpha25-dihydroxyvitamin D3 in chick parathyroid glands.

1975 • 182 citations

Vitamin D-regulated gene expression.

1993 • 181 citations

AN Experimental Investigation ON RICKETS.

1919 • 177 citations

The role of 1,25-dihydroxyvitamin D3 and parathyroid hormone in the regulation of chick renal 25-hydroxyvitamin D3-24-hydroxylase

1975 • 175 citations

1,25-Dihydr oxyvitamin D₃Treatment Results in Increased Choline Acetyltransferase Activity in Specific Brain Nuclei*

1986 • 175 citations

1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D ₃ Active on Bone in Anephric Rats

1972 • 171 citations

The Synthesis of [1,2-³H] Vitamin D₃ and the Tissue Localization of a 0.25-μg (10 IU) Dose per Rat^*

1966 • 170 citations

Vitamin D is not directly necessary for bone growth and mineralization

1984 • 170 citations

Mechanism of Action and Metabolic Fate of Vitamin D

1967 • 168 citations

Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses.

1993 • 165 citations

Specific binding of 1alpha,25-dihydroxycholecalciferol to nuclear components of chick intestine.

1975 • 165 citations

STRUCTURAL ORGANIZATION OF THE HUMAN ANDROGEN RECEPTOR GENE

1989 • 165 citations

Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene.

1994 • 164 citations

Vitamin D and adaptation to dietary calcium and phosphate deficiencies increase intestinal plasma membrane calcium pump gene expression.

1993 • 164 citations

1α,25-dihydroxy-19-nor-vitamin D3, a novel vitamin D-related compound with potential therapeutic activity

1990 • 161 citations

Intestinal cytosol binders of 1,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3

1976 • 159 citations

Über das antirachitisch wirksame Bestrahlungsprodukt ans 7-Dehydro-cholesterin.

1936 • 159 citations

Evidence That 1,25-Dihydroxyvitamin D₃Is the Physiologically Active Metabolite of Vitamin D₃*

1985 • 157 citations

Vitamin D receptor interaction with specific DNA. Association as a 1,25-dihydroxyvitamin D3-modulated heterodimer.

1991 • 156 citations

Synthesis of mc 903, a biologically active vitamin D metabolite analogue

1987 • 156 citations

Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.

1984 • 155 citations

Vitamin D deficiency and renal calcium transport in the rat.

1984 • 155 citations

1,25-Dihydroxyvitamin D3 receptor-like macromolecule in rat osteogenic sarcoma cell lines.

1980 • 154 citations

Regulation of collagen synthesis in fetal rat calvaria by 1,25-dihydroxyvitamin D3.

1982 • 149 citations

Tracer Experiments on the Effect of Vitamin D on the Skeletal Metabolism of Calcium and Phosphorus

1952 • 149 citations

Vitamin D Deficiency Suppresses Cell-Mediated Immunity in Vivo

1993 • 146 citations

Isolation and characterization of the rat α1(I) collagen promoter

1989 • 145 citations

Appearance of the intestinal cytosolic receptor for 1,25-dihydroxyvitamin D3 during neonatal development in the rat.

1981 • 144 citations

Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA.

1993 • 144 citations

1,25-Dihydroxyvitamin D3 and the regulation of macrophage function

1981 • 144 citations

Hormone-dependent phosphorylation of the 1,25-dihydroxyvitamin D3 receptor in mouse fibroblasts

1985 • 142 citations

Effect of 1,25 Dihydroxyvitamin D3 on Insulin Secretion

1981 • 142 citations

An ochre mutation in the vitamin D receptor gene causes hereditary 1,25-dihydroxyvitamin D3-resistant rickets in three families.

1989 • 142 citations

Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells.

1990 • 141 citations

Specific cytosol-binding protein for 1,25-dihydroxyvitamin D3 in rat intestine.

1977 • 141 citations

Osteocalcin

1988 • 139 citations

Functional Domains of the Human Vitamin D₃Receptor Regulate Osteocalcin Gene Expression

1989 • 139 citations

The effects of 1,25-dihydroxyvitamin D3 on human T lymphocyte activation and proliferation: a cell cycle analysis.

1985 • 137 citations

Isolation and expression of rat 1,25-dihydroxyvitamin D3 receptor cDNA.

1988 • 133 citations

Changes in DNA associated with induction of erythroid differentiation by dimethyl sulfoxide in murine erythroleukemia cells.

1978 • 132 citations

The nuclear-bound form of the progesterone receptor is generated through a hormone-dependent phosphorylation

1985 • 132 citations

Isolation and characterization of 1.alpha.-hydroxy-23-carboxytetranorvitamin D: a major metabolite of 1,25-dihydroxyvitamin D3

1979 • 129 citations

Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor.

1991 • 128 citations

Target cells for 1,25 dihydroxyvitamin D3 in the pancreas

1980 • 128 citations

Functional antagonism between vitamin D3 and retinoic acid in the regulation of CD14 and CD23 expression during monocytic differentiation of U-937 cells.

1993 • 127 citations

Vitamin D analogs with low affinity for the vitamin D binding protein: Enhanced in vitro and decreased in vivo activity

1991 • 124 citations

The synthesis of 1α,25-dihydroxycholecalciferol -- A metabolically active form of vitamin D3

1972 • 123 citations

Osteocalcin secretion by the human osteosarcoma cell line MG-63

1990 • 123 citations

1,25-Dihydroxyvitamin D3 receptors in parathyroid glands. Preliminary characterization of cytoplasmic and nuclear binding components

1978 • 122 citations

Monoclonal antibodies to the porcine intestinal receptor for 1,25-dihydroxyvitamin D3: interaction with distinct receptor domains

1986 • 122 citations

Vitamin D and mineral deficiencies increase the plasma membrane calcium pump of chicken intestine

1992 • 121 citations

Autoradiographic localization of target cells for 1α, 25-dihydroxyvitamin D3 in bones from fetal rats

1983 • 119 citations

The Biochemistry and Physiology of Vitamin D

1953 • 118 citations

Structure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor.

1988 • 117 citations

Serum and monoclonal antibodies against the chick intestinal receptor for 1,25-dihydroxyvitamin D3. Generation by a preparation enriched in a 64,000-dalton protein.

1983 • 117 citations

Induction of monocytic differentiation of HL-60 cells by 1,25-dihydroxyvitamin D analogs.

1987 • 116 citations

Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition site

1993 • 115 citations

Phosphorylation of serine 208 in the human vitamin D receptor. The predominant amino acid phosphorylated by casein kinase II, in vitro, and identification as a significant phosphorylation site in intact cells.

1993 • 115 citations

Regulating transcription factor activity by phosphorylation

1992 • 115 citations

Cellular and subcellular localization of 1,25-(OH)2-vitamin D3 in rat kidney: comparison with localization of parathyroid hormone and estradiol.

1980 • 114 citations

The synthesis of 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3

1969 • 113 citations

The effect of 1,25-dihydroxyvitamin D3 on in vitro immunoglobulin production in human B cells.

1986 • 113 citations

Homologous up-regulation of the 1,25 (OH)2 vitamin D3 receptor in rats

1986 • 113 citations

Hormonal Regulation of Estrogen Receptor Messenger Ribonucleic Acid in T47D_COand MCF-7 Breast Cancer Cells

1989 • 112 citations

Transcriptional regulation of the c-myc protooncogene by 1,25-dihydroxyvitamin D3 in HL-60 promyelocytic leukemia cells.

1987 • 111 citations

Vitamin D3 from rat skins irradiated in vitro with ultraviolet light

1978 • 110 citations

A 55-Kilodalton Accessory Factor Facilitates Vitamin D Receptor DNA Binding

1991 • 109 citations

The distillation of vitamin D

1930 • 109 citations

EVIDENCE FOR A PREVIOUSLY UNIDENTIFIED UPSTREAM EXON IN THE HUMAN OESTROGEN RECEPTOR GENE.

1991 • 107 citations

A SYNTHETIC ANALOGUE OF VITAMIN D₃, 22-OXA-lα,25-DIHYDROXYVITAMIN D₃IS A POTENT MODULATOR OF IN VIVO IMMUNOREGULATING ACTIVITY WITHOUT INDUCING HYPERCALCEMIA IN MICE

1989 • 106 citations

Purification of chicken intestinal receptor for 1,25-dihydroxyvitamin D.

1979 • 105 citations

1,25-Dihydroxyvitamin D3 restores fertility of vitamin D-deficient female rats

1989 • 105 citations

1,25-Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation. Up-regulation of the mannose receptor.

1987 • 104 citations

Normalization of Serum Calcium Restores Fertility in Vitamin D-Deficient Male Rats

1992 • 102 citations

Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3.

1993 • 101 citations

Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae.

1989 • 101 citations

Presence of a 1,25-dihydroxy-vitamin D3 receptor in chick skeletal muscle myoblasts

1985 • 101 citations

Phosphorylation of steroid receptors

1989 • 100 citations

Immunocytology with microwave-fixed fibroblasts shows 1 alpha,25-dihydroxyvitamin D3-dependent rapid and estrogen-dependent slow reorganization of vitamin D receptors.

1990 • 99 citations

The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites.

1990 • 99 citations

Effect of vitamin D3 on the pancreatic secretion of insulin and somatostatin

1984 • 98 citations

Effect of Hormones and Development on the Expression of the Rat 1,25-Dihydroxyvitamin D3 Receptor Gene

1989 • 95 citations

A nuclear protein essential for binding of rat 1,25-dihydroxyvitamin D3 receptor to its response elements.

1992 • 94 citations

Phosphorylation of rat liver glucocorticoid receptor.

1985 • 94 citations

Stabilization of the vitamin D receptor in rat osteosarcoma cells through the action of 1,25-dihydroxyvitamin D3.

1993 • 93 citations

Phosphorylation of the 1,25-dihydroxyvitamin D3 receptor. A primary event in 1,25-dihydroxyvitamin D3 action.

1990 • 92 citations

An estrogen-stimulated 1,25-dihydroxyvitamin D3 receptor in rat uterus

1981 • 91 citations

Regions of the rat osteocalcin gene which mediate the effect of 1,25-dihydroxyvitamin D3 on gene transcription

1989 • 90 citations

Retinoic acid stimulates 1,25-dihydroxyvitamin D3 binding in rat osteosarcoma cells.

1984 • 89 citations

Decreased c-myc expression is an early event in retinoic acid-induced differentiation of F9 teratocarcinoma cells.

1986 • 89 citations

Biological activity of a vitamin D metabolite

1967 • 86 citations

1α,25-Dihydroxyvitamin D₃Receptor Distribution and Effects in Subpopulations of Normal Human T Lymphocytes*

1989 • 86 citations

Nuclear and cytoplasmic binding components for vitamin D metabolites

1975 • 83 citations

Stimulation of 1,25-dihydroxyvitamin D3 receptor gene expression in cultured cells by serum and growth factors

1991 • 82 citations

Regulation of calcitonin gene transcription by vitamin D metabolites in vivo in the rat.

1988 • 77 citations

Impairment of cytokine production in mice fed a vitamin D3-deficient diet.

1991 • 77 citations

Vitamin D-dependency rickets type II: truncated vitamin D receptor in three kindreds

1993 • 74 citations

Vitamin D and the immune system

1987 • 74 citations

Identification of a RNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression

1990 • 73 citations

THE RELATION OF THE UNIDENTIFIED DIETARY FACTORS, THE FAT-SOLUBLE A, AND WATERSOLUBLE B, OF THE DIET TO THE GROWTHPROMOTING PROPERTIES OF MILK

1916 • 73 citations

24-Homologated 1,25-dihydroxyvitamin D3 compounds: separation of calcium and cell differentiation activities

1990 • 72 citations

Effects of vitamin D3 metabolites on calcium fluxes in intact chicken skeletal muscle and myoblasts culturedin vitro

1984 • 72 citations

Oestradiol stimulates tyrosine phosphorylation and hormone binding activity of its own receptor in a cell-free system.

1987 • 70 citations

Characterization of the 1 alpha,25-dihydroxyvitamin D3 receptor from rat intestinal cytosol.

1979 • 68 citations

Placental transport of calcium and phosphorus is not regulated by vitamin D

1984 • 67 citations

Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies.

1990 • 67 citations

Cyclic adenosine 3',5'-monophosphate up-regulates 1,25-dihydroxyvitamin D3 receptor gene expression and enhances hormone action.

1992 • 65 citations

Serum calcium and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in rat kidney in vivo.

1990 • 65 citations

Metabolism of 25-hydroxycholecalciferol in target and nontarget tissues

1970 • 64 citations

Effects of increasing doses of 1α-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women

1994 • 64 citations

Rat renal 25-hydroxyvitamin D3 1- and 24-hydroxylases: their in vivo regulation

1984 • 63 citations

DEFECTIVE NEUTROPHIL MOTILITY IN HYPOVITAMINOSIS D RICKETS

1976 • 63 citations

Identification of the porcine intestinal 1,25-dihydroxyvitamin D3 receptor on sodium dodecyl sulfate/polyacrylamide gels by renaturation and immunoblotting.

1985 • 63 citations

The subcellular distribution of physiological doses of vitamin D3

1967 • 63 citations

Hereditary Resistance to 1,25-Dihydroxyvitamin D

1984 • 62 citations

1α,25-dihydroxyvitamin D3 a nd 19-nor-1α,25-dihydroxyvitamin 32 suppress immunoglobulin production and thymic lymphocyte proliferation in vivo

1993 • 61 citations

Negative regulatory elements in the human parathyroid hormone gene.

1991 • 60 citations

Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays.

1992 • 60 citations

Chicken intestinal receptor for 1,25-dihydroxyvitamin D3. Immunologic characterization and homogeneous isolation of a 60,000-dalton protein.

1987 • 59 citations

Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems.

1993 • 59 citations

Induction of calbindin-D 9k mRNA but not calcium transport in rat intestine by 1,25-dihydroxyvitamin D3 24-homologs

1991 • 58 citations

Intestinal calcium transport: Evidence for two distinct mechanisms of action of 1,25-dihydroxyvitamin D3

1981 • 57 citations

Expression of Calcium-Binding Proteins MRP8 and MRP14 Is Associated with Distinct Monocytic Differentiation Pathways in HL-60 Cells

1993 • 56 citations

EVALUATION OF PHAGOCYTOSIS IN RICKETS

1970 • 56 citations

Phosphorylation is involved in transcriptional activation by the 1,25-dihydroxyvitamin D3 receptor

1993 • 54 citations

Studies on the site of 1,25-dihydroxyvitamin D3 synthesis in vivo.

1983 • 54 citations

Interferon-gamma-induced IA expression in WEHI-3 cells is enhanced by the presence of 1,25-dihydroxyvitamin D3.

1986 • 54 citations

THE CONTROL OF CALCIUM AND PHOSPHORUS METABOLISM BY THE VITAMIN D ENDOCRINE SYSTEM*

1980 • 50 citations

Demonstration and Characterisation of a Testicular Receptor for 1,25‐Dihydroxycholecalciferol in the Rat

1983 • 49 citations

Possible significance of new target tissues for 1,25-dihydroxyvitamin D3

1983 • 49 citations

1,25-Dihydroxyvitamin D3 and the Immune System

1989 • 48 citations

The vitamin D—induced differentiation of HL-60 cells: Structural requirements

1987 • 46 citations

Regulation of natural killer cytotoxicity by 1,25-dihydroxyvitamin D3

1989 • 46 citations

Purification of chicken intestinal receptor for 1 alpha, 25-dihydroxyvitamin D3 to apparent homogeneity.

1982 • 46 citations

Impaired macrophage activation in vitamin D3 deficiency: differential in vitro effects of 1,25-dihydroxyvitamin D3 on mouse peritoneal macrophage functions.

1989 • 45 citations

Subcellular location and properties of rat renal 25-hydroxyvitamin D3-1 alpha-hydroxylase.

1985 • 45 citations

Appearance of the arachidonic acid metabolic pathway in human promyelocytic leukemia (HL-60) cells during monocytic differentiation: enhancement of thromboxane synthesis by 1α,25-dihydroxy vitamin D-3

1986 • 43 citations

Ca2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line.

1988 • 43 citations

Heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor by parathyroid hormone (PTH) and PTH-like peptide in osteoblast-like cells

1988 • 43 citations

Phosphorylation of the Human 1,25-Dihydroxyvitamin D3 Receptor by cAMP-Dependent Protein-Kinase, In Vitro, and in Transfected COS-7 Cells

1993 • 42 citations

Overproduction of rat 1,25-dihydroxyvitamin D3 receptor in insect cells using the baculovirus expression system.

1991 • 41 citations

Induction of a high phagocytic capability in P388D1, a macrophage-like tumor cell line, by 1 alpha, 25-dihydroxyvitamin D3.

1984 • 40 citations

1,25-Dihydroxyvitamin D3-stimulated mRNAs in rat small intestine

1986 • 40 citations

The Effect of l-αHydroxyvitamin D₃oil Cell-Mediated Immunity in Hemodialyzed Patients

1986 • 39 citations

Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by parathyroid hormone and cAMP-agonists

1992 • 39 citations

Changes in cytoskeletal proteins in response to parathyroid hormone and 1,25-dihydroxyvitamin D in human osteoblastic cells

1990 • 38 citations

Vitamin D-influenced gene expression via a ligand-independent, receptor-DNA complex intermediate.

1993 • 38 citations

Transcriptional control of vitamin D‐regulated proteins

1992 • 37 citations

Antirachitic properties imparted to lettuce and to growing wheat by ultraviolet irradiation.

1924 • 35 citations

1,25-Dihydroxyvitamin D₃Receptors in Rat Lung during the Perinatal Period: Regulation and Immunohistochemical Localization

1990 • 35 citations

Sites of phosphorylation and photoaffinity labeling of the 1,25-dihydroxyvitamin D3 receptor

1991 • 35 citations

Vitamin D Receptor Phosphorylation in Transfected ROS 17/2.8 Cells Is Localized to the N-Terminal Region of the Hormone-Binding Domain

1991 • 34 citations

VITAMIN D AND CALCIUM TRANSPORT*

1978 • 34 citations

1α,25-Dihydroxyvitamin D3 receptors in human thymic and tonsillar lymphocytes

1987 • 33 citations

Central histaminergic stimulation of pituitary - adrenocortical response in the rat

1983 • 33 citations

Suppression of 1,25-dihydroxy-vitamin D3-dependent calcium transport by protein synthesis inhibitors and changes in phospholipids in skeletal muscle

1985 • 32 citations

Purification of the receptor for 1.alpha.,25-dihydroxyvitamin D3 from chicken intestine

1983 • 31 citations

Isolation of a mRNA that encodes a putative intestinal alkaline phosphatase regulated by 1,25-dihydroxyvitamin D-3

1991 • 30 citations

Autoradiographic demonstration of target cells for 1,25-dihydroxycholecalciferol in the chick embryo chorioallantoic membrane, duodenum, and parathyroid glands

1980 • 30 citations

Effect of 1,25-Dihydroxyvitamin D₃on Insulin Secretion: Direct or Mediated?

1986 • 29 citations

The necessity for calcium for increased renal vitamin D receptor in response to 1,25-dihydroxyvitamin D

1993 • 29 citations

Effect of Vitamin D deficiency on macrophage and lymphocyte function in the rat

1989 • 28 citations

Autoradiographic Localization of 1,25-Dihydroxyvitamin D<sub>3</sub> in Rat Placenta and Yolk Sac

1983 • 27 citations

Vitamin D–Dependent Rickets

1985 • 27 citations

Functional involvement of calcium in the homologous up‐regulation of the 1,25‐dihydroxyvitamin D₃ receptor in osteoblast‐like cells

1990 • 26 citations

1,25-Dihydroxyvitamin D3 inhibits the passive transfer of cellular immunity by a myelin basic protein-specific T cell clone

1992 • 26 citations

The expression of milligram amounts of functional human 1,25-dihydroxyvitamin D3 receptor in a bacterial expression system

1992 • 25 citations

Stimulation of cellular alkaline phosphatase activity and its messenger RNA level in a human osteosarcoma cell line by 1,25-dihydroxyvitamin D3

1989 • 24 citations

On the role of vitamin D in calcification.

1958 • 24 citations

Appearance of the rat testicular receptor for calcitriol (1,25-dihydroxyvitamin D3) during development

1985 • 23 citations

Effect of 1, 25-dihydroxyvitamin D3 on pancreatic B and D cell function

1983 • 23 citations

1,25-Dihydroxyvitamin D3 Receptor and Role of 1,25-(OH)2D3 in Human Cancer Cells

1984 • 22 citations

Partial amino acid sequence of porcine 1,25-dihydroxyvitamin D3 receptor isolated by immunoaffinity chromatography.

1988 • 21 citations

1,25-Dihydroxyvitamin D<sub>3</sub> Target Cells in Rat Mammary Gland

1981 • 20 citations

Dietary vitamin D affects cell-mediated hypersensitivity but not resistance to experimental pulmonary tuberculosis in guinea pigs

1993 • 20 citations

Clinical Trial of 26,26,26,27,27,27-Hexafluoro-1,25-Dihydroxyvitamin D3 in Uremic Patients on Hemodialysis: Preliminary Report

2015 • 20 citations

Identification of lamin B and histones as 1,25-dihydroxyvitamin D3-regulated nuclear phosphoproteins in HL-60 cells.

1992 • 19 citations

Regulation of the intestinal 1,25-dihydroxyvitamin D3 receptor during neonatal development in the rat

1988 • 19 citations

Unique rearrangement of ergocalciferol side chain in vitro: production of a biologically highly active homologue of 1,25-dihydroxyvitamin D3

1986 • 19 citations

Delayed hypersensitivity response and vitamin D deficiency.

1983 • 19 citations

Overexpression of the Human Vitamin D₃Receptor in Mammalian Cells using Recombinant Adenovirus Vectors

1991 • 17 citations

Biological activity of 1,25-dihydroxyvitamin D2 and 24-epi-1,25-dihydroxyvitamin D2

1988 • 16 citations

Distinct Target Cells and Effects of lα,25-Dihydroxyvitamin D₃and Glucocorticoids in the Rat Thymus Gland*

1989 • 15 citations

Synthesis of some side-chain homologues of 1.ALPHA.,25-dihydroxyvitamin D3 and investigation of their biological activities.

1986 • 14 citations

A single receptor identical with that from intestine/T47D cells mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells

1992 • 14 citations

Metabolic Studies on Vitamin D

2008 • 13 citations

Perturbations of rat intestinal brush border membranes induced by Ca2+and vitamin D3 are detected using steady-state fluorescence polarization and alkaline phosphatase as membrane probes

1986 • 11 citations

1,25-Dihydroxyvitamin D-3 destabilizes c-myc mRNA in HL-60 leukemic cells

1993 • 11 citations

Vitamin D in the Differentiation of Myeloid Leukemia Cells

1984 • 11 citations

Baculovirus-mediated expression of retinoic acid receptor type gamma in cultured insect cells reveals a difference in specific DNA-binding behavior with the 1,25-dihydroxyvitamin D3 receptor.

1992 • 10 citations

Subcellular distribution of DNA-binding and non-DNA-binding 1,25-dihydroxyvitamin D receptors in chicken intestine.

1984 • 8 citations

[The unspecific reaction of inflammation in rickets due to lack of vitamin D (author's transl)].

1975 • 6 citations

Significance of Vitamin D in Age-Related Bone Disease

1986 • 5 citations

Delayed Hypersensitivity in Primary and Secondary Hyperparathyroidism. Treatment with Active Vitamin D

2009 • 5 citations

[Changes in the immune mechanisms in infants with hypocalcemic rickets].

1967 • 5 citations

Vitamin D and its Metabolites: Physiology, Biochemistry and Pharmacology

1979 • 1 citations