Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics

1999 • 656 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

Cortical Actin Organization: Lessons from ERM (Ezrin/Radixin/Moesin) Proteins

1999 • 464 citations

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

1994 • 453 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Signaling inputs converge on nuclear effectors in TGF-β signaling

2000 • 359 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

Regulation of Nuclear Localization: A Key to a Door

1999 • 303 citations

Microtubule Binding to Smads May Regulate TGFβ Activity

2000 • 277 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of Ikappa Balpha

1999 • 264 citations

Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression

1999 • 262 citations

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 • 261 citations

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

1999 • 252 citations

Activation of the human beta-interferon gene requires an interferon-inducible factor.

1986 • 237 citations

Alternatively Spliced Variant of Smad2 Lacking Exon 3

1999 • 235 citations

mRNA Profiling of Rat Islet Tumors Reveals Nkx 6.1 as a β-Cell-specific Homeodomain Transcription Factor

1996 • 210 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway

1997 • 197 citations

The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain

2000 • 177 citations

Importin β Mediates Nuclear Translocation of Smad 3

2000 • 165 citations

Nuclear localization of the p120 ^ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression

1999 • 153 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells

1997 • 134 citations

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.

1995 • 110 citations

Identification of Two Smad4 Proteins in Xenopus

1999 • 95 citations

Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes

1999 • 92 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1997 • 19 citations

DPC4 splice variants in neuroblastoma

1998 • 12 citations