Familial polyposis: recent advances

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Hereditary Colorectal Cancer

2003 • 2,142 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Relation of Meat, Fat, and Fiber Intake to the Risk of Colon Cancer in a Prospective Study among Women

1990 • 1,258 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

1974 • 717 citations

The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

1987 • 683 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

1993 • 627 citations

Alleles of the APC gene: An attenuated form of familial polyposis

1993 • 621 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Molecular Diagnosis of Familial Adenomatous Polyposis

1993 • 588 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Chromosome 5 allele loss in human colorectal carcinomas

1987 • 566 citations

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

1992 • 562 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.

1992 • 551 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1994 • 513 citations

Gardner syndrome in a man with an interstitial deletion of 5q

1986 • 458 citations

Human-tumor-derived cell lines contain common and different transforming genes

1981 • 455 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

Sulindac for polyposis of the colon

1989 • 418 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum.

1951 • 406 citations

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource

1985 • 402 citations

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

1990 • 386 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

Transforming activity of human tumor DNAs.

1981 • 374 citations

Allelic Loss in Colorectal Carcinoma

1989 • 338 citations

Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.

1992 • 337 citations

Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients

1993 • 320 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]

1989 • 273 citations

Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.

1992 • 269 citations

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

1992 • 257 citations

Hereditary Nonpolyposis Colorectal Cancer—Lynch Syndromes I and II

1988 • 255 citations

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.

1992 • 237 citations

Dominant Inheritance of Adenomatous Colonic Polyps and Colorectal Cancer

1985 • 231 citations

Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment.

1981 • 229 citations

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma

1992 • 229 citations

The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.

1992 • 223 citations

Desmoid Tumors in Familial Polyposis Coli

1986 • 208 citations

Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5.

1988 • 196 citations

Association between wild type and mutant APC gene products.

1993 • 194 citations

Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

1991 • 184 citations

Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma.

1984 • 182 citations

Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 182 citations

Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.

1990 • 179 citations

Evidence for the presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma.

1993 • 173 citations

The occult osteomatous changes in the mandible in patients with familial polyposis coli

1975 • 158 citations

Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli

1988 • 157 citations

Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis.

1993 • 152 citations

Construction of Mouse A9 Clones Containing a Single Human Chromosome Tagged with Neomycin‐resistance Gene via Microcell Fusion

1989 • 150 citations

Concerted Nonsyntenic Allelic Loss in Human Colorectal Carcinoma

1988 • 147 citations

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.

1993 • 143 citations

Human colorectal cancer: high frequency of deletions at chromosome 1p35.

1990 • 140 citations

Mutational analysis of patients with adenomatous polyposis: identical inactivating mutations in unrelated individuals.

1993 • 139 citations

The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients

1984 • 139 citations

Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.

1993 • 129 citations

Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence.

1990 • 125 citations

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)

1992 • 120 citations

High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22.

1989 • 117 citations

Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential

1994 • 109 citations

Hereditary Colorectal Cancer

1990 • 102 citations

Consistent deficiencies of chromosome 18 and of the short arm of chromosome 17 in eleven cases of human large bowel cancer: a possible recessive determinism.

1985 • 100 citations

Loss of alleles on chromosome 18 and on the short arm of chromosome 17 in polyploid colorectal carcinomas

1988 • 97 citations

Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.

1993 • 95 citations

Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome.

1988 • 92 citations

Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 87 citations

Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers.

1993 • 85 citations

Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma.

1989 • 81 citations

Decreased expression of DCC mRNA in human colorectal cancers

1993 • 80 citations

Close linkage of a highly polymorphic marker (D5S37) to familial adenomatous polyposis (FAP) and confirmation of FAP localization on chromosome 5q21-q22

1988 • 79 citations

Amplification units containing human N-myc and c-myc genes.

1986 • 78 citations

Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region.

1993 • 75 citations

Extracolonic manifestations of familial polyposis coli

1987 • 74 citations

Deletion mapping in colorectal cancer of a putative tumour suppressor gene in 8p22-p21.3.

1993 • 69 citations

Genetic Changes and Histopathological Grades in Human Hepatocellular Carcinomas

1993 • 56 citations

Noncorrelation of the expression of the c-myc oncogene in colorectal carcinoma with recurrence of disease or patient survival.

1988 • 54 citations

Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis

1990 • 53 citations

Immortalization of a human colorectal adenoma cell line by continuous in vitro passage: Possible involvement of chromosome 1 in tumour progression

1988 • 51 citations

A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC.

1993 • 50 citations

Chromosome 5 allele loss in familial and sporadic colorectal adenomas

1989 • 43 citations

Loss of normal allele of the APC gene in an adrenocortical carcinoma from a patient with familial adenomatous polyposis

1992 • 40 citations

Deletions in the short arm of chromosome 8 are present in up to 90% of human colorectal cancer cell lines

1992 • 36 citations

The Concept of Hereditary Colorectal Cancer and the Implications of Its Study

1990 • 28 citations

Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5.

1990 • 27 citations

Recent progress in colorectal cancer: biology and management of high risk groups

1992 • 19 citations

Misincorporation in DNA synthesis after modification of template or polymerase by MNNG, MMS and UV radiation

1983 • 11 citations

Establishment and Characterization of an Epithelial Cell Line with Quasi‐normal Chromosomes from a Tubular Adenoma of a Familial Polyposis Coli Patient

1991 • 9 citations

Chemical and viral transformation of cultured skin fibroblasts from patients with familial polyposis coli

1988 • 8 citations

The Peutz-Jeghers Syndrome and Malignant Tumor

1990 • 6 citations

Familial Adenomatous Polyposis

2013 • 4 citations