A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC.

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

1985 • 1,207 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

1987 • 683 citations

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

1992 • 562 citations

Common Inheritance of Susceptibility to Colonic Adenomatous Polyps and Associated Colorectal Cancers

1988 • 472 citations

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource

1985 • 402 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

Dominant Inheritance of Adenomatous Colonic Polyps and Colorectal Cancer

1985 • 231 citations

Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage

1991 • 220 citations

Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5.

1988 • 196 citations

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). II. Biomarker studies

1985 • 165 citations

Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.

1992 • 147 citations

Mutational analysis of patients with adenomatous polyposis: identical inactivating mutations in unrelated individuals.

1993 • 139 citations

A CA repeat 30–70 Kb downstream from the adenomatous polyposis coli (APC) gene

1992 • 136 citations

Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.

1993 • 129 citations

Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis

1992 • 112 citations

Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.

1993 • 95 citations

The Adenomatous Polyp and the Hereditary Polyposis Syndromes

1988 • 67 citations

CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC)

1991 • 52 citations

CA repeat polymorphism at the D5S82 locus, proximal to adenomatous polyposis coli (APC)

1991 • 51 citations

CA repeat polymorphism within the MCC (mutated in colorectal cancer) gene

1991 • 32 citations