Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Viral Strategies of Immune Evasion

1998 • 791 citations

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

1993 • 771 citations

Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis

1994 • 750 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

Association between Prior Cytomegalovirus Infection and the Risk of Restenosis after Coronary Atherectomy

1996 • 446 citations

Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays

1998 • 445 citations

The Human Myt1 Kinase Preferentially Phosphorylates Cdc2 on Threonine 14 and Localizes to the Endoplasmic Reticulum and Golgi Complex

1997 • 354 citations

Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor.

1994 • 340 citations

Cytomegalovirus encodes a potent α chemokine

1999 • 339 citations

Human Cytomegalovirus Inhibits Major Histocompatibility Complex Class II Expression By Disruption of the Jak/Stat Pathway

1998 • 337 citations

A link between MAP kinase and p34cdc2/cyclin B during oocyte maturation: p90rsk phosphorylates and inactivates the p34cdc2 inhibitory kinase Myt1

1998 • 319 citations

Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption

1999 • 303 citations

Chemokine Sequestration by Viral Chemoreceptors as a Novel Viral Escape Strategy: Withdrawal of Chemokines from the Environment of Cytomegalovirus-infected Cells

1998 • 298 citations

Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs

1997 • 298 citations

Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

1995 • 285 citations

Human cytomegalovirus encodes three G protein-coupled receptor homologues

1990 • 281 citations

Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells

1999 • 267 citations

The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells

1997 • 250 citations

Human Cytomegalovirus Inhibits Cellular DNA Synthesis and Arrests Productively Infected Cells in Late G1

1996 • 211 citations

Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment

1997 • 205 citations

Engagement of the Cellular Receptor for Glycoprotein B of Human Cytomegalovirus Activates the Interferon-Responsive Pathway

1999 • 200 citations

Human cytomegalovirus infection inhibits G1/S transition

1997 • 197 citations

Formation of STAT1-STAT2 Heterodimers and Their Role in the Activation of IRF-1 Gene Transcription by Interferon-α

1996 • 196 citations

ASSOCIATION BETWEEN PRIOR CYTOMEGALOVIRUS INFECTION AND THE RISK OF RESTENOSIS AFTER CORONARY ATHERECTOMY

1996 • 195 citations

Modulation of Natural Killer Cell Cytotoxicity in Human Cytomegalovirus Infection: The Role of Endogenous Class I Major Histocompatibility Complex and a Viral Class I Homolog

1998 • 194 citations

Cell Cycle Dysregulation by Human Cytomegalovirus: Influence of the Cell Cycle Phase at the Time of Infection and Effects on Cyclin Transcription

1998 • 183 citations

Disruption of PML Subnuclear Domains by the Acidic IE1 Protein of Human Cytomegalovirus Is Mediated through Interaction with PML and May Modulate a RING Finger-Dependent Cryptic Transactivator Function of PML

1998 • 176 citations

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S

1996 • 175 citations

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

1999 • 173 citations

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

1998 • 165 citations

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

1994 • 164 citations

Aspirin Attenuates Cytomegalovirus Infectivity and Gene Expression Mediated by Cyclooxygenase-2 in Coronary Artery Smooth Muscle Cells

1998 • 162 citations

Human cytomegalovirus inhibits IFN-alpha-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-alpha signal transduction.

1999 • 161 citations

Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3-Containing Interferon-Stimulated Response Element-Binding Complex

1998 • 158 citations

Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene

1997 • 146 citations

The Cytomegalovirus US28 Protein Binds Multiple CC Chemokines with High Affinity

1995 • 145 citations

Inhibition of Cellular Cdk2 Activity Blocks Human Cytomegalovirus Replication

1997 • 143 citations

Intracellular Signaling by the Chemokine Receptor US28 during Human Cytomegalovirus Infection

1998 • 142 citations

Functional Analysis of the Human Cytomegalovirus US28 Gene by Insertion Mutagenesis with the Green Fluorescent Protein Gene

1998 • 140 citations

Human Cytomegalovirus Inhibits IFN-α-Stimulated Antiviral and Immunoregulatory Responses by Blocking Multiple Levels of IFN-α Signal Transduction

1999 • 134 citations

Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product.

1998 • 132 citations

Effects of Human Cytomegalovirus Immediate-Early Proteins on p53-mediated Apoptosis in Coronary Artery Smooth Muscle Cells

1999 • 127 citations

Divergent patterns of ELAM-1, ICAM-1, and VCAM-1 expression on cytomegalovirus-infected endothelial cells.

1994 • 126 citations

p53 and RPA Are Sequestered in Viral Replication Centers in the Nuclei of Cells Infected with Human Cytomegalovirus

1998 • 126 citations

The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter

1996 • 116 citations

Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein

1994 • 111 citations

Role of Reactive Oxygen Intermediates in Cytomegalovirus Gene Expression and in the Response of Human Smooth Muscle Cells to Viral Infection

1996 • 110 citations

Extracellular Signal-Regulated Kinase Activity Is Sustained Early during Human Cytomegalovirus Infection

1998 • 107 citations

Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts

1994 • 103 citations

Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling

1995 • 98 citations

Human cytomegalovirus alters interleukin-6 production by endothelial cells

1994 • 94 citations

The Cyclin E Promoter Is Activated by Human Cytomegalovirus 86-kDa Immediate Early Protein

1998 • 92 citations

Specific chromosome 1 breaks induced by human cytomegalovirus

2000 • 91 citations

Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells.

1994 • 89 citations

CYTOMEGALOVIRUS INDUCED UP-REGULATION OF LFA-3 (CD58) AND ICAM-1(CD54) IS A DIRECT VIRAL EFFECT THAT IS NOT PREVENTED BY GANCICLOVIR OR FOSCARNET TREATMENT1

1996 • 88 citations

Modulation of RANTES production by human cytomegalovirus infection of fibroblasts

1997 • 86 citations

INTERCELLULAR ADHESION MOLECULE-1 EXPRESSION IN ENDOTHELIAL CELLS IS ACTIVATED BY CYTOMEGALOVIRUS IMMEDIATE EARLY PROTEINS1

1999 • 85 citations

Enhancement human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8

1994 • 82 citations

Escape of Human Cytomegalovirus from HLA-DR-Restricted CD4⁺T-Cell Response Is Mediated by Repression of Gamma Interferon-Induced Class II Transactivator Expression

1999 • 78 citations

Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function

1997 • 75 citations

Phosphorylation of the Human Cytomegalovirus 86-Kilodalton Immediate-Early Protein IE2

1998 • 68 citations

Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other

1997 • 68 citations

Regulation of Human Cytomegalovirus Gene Expression

1999 • 58 citations

Cytomegalovirus- and interferon-related effects on human endothelial cells

1992 • 57 citations

Human Cytomegalovirus Inhibits Transcription of the CC Chemokine MCP-1 Gene

1999 • 52 citations

Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by cytomegalovirus infection of smooth muscle cells.

1997 • 51 citations

Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle.

1996 • 49 citations

Human cytomegalovirus alters interleukin-6 production by endothelial cells

1994 • 39 citations

Metabolic and cellular effects of human cytomegalovirus infection.

1991 • 38 citations

The Retinoblastoma Gene Product Negatively Regulates Transcriptional Activation Mediated by the Human Cytomegalovirus IE2 Protein

1995 • 34 citations

Hyperimmediate entry of human cytomegalovirus virions and dense bodies into human fibroblasts

1994 • 31 citations

Altered production of GM-CSF and IL-8 in cytomegalovirus-infected, IL-1-primed umbilical cord endothelial cells.

1997 • 25 citations

Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis

1999 • 24 citations