Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis

1994 • 750 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

Human cytomegalovirus IE1 and IE2 proteins block apoptosis

1995 • 471 citations

Different Roles for Cyclins D1 and E in Regulation of the G₁-to-S Transition

1995 • 469 citations

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

1987 • 317 citations

Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element

1989 • 311 citations

High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis.

1990 • 310 citations

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

1988 • 298 citations

Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

1995 • 285 citations

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

1992 • 280 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

1990 • 216 citations

A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation.

1996 • 214 citations

Human Cytomegalovirus Inhibits Cellular DNA Synthesis and Arrests Productively Infected Cells in Late G1

1996 • 211 citations

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains

1990 • 197 citations

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID

1992 • 195 citations

Cytomegalovirus DNA in arterial walls of patients with atherosclerosis

1994 • 189 citations

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

1994 • 164 citations

Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site

1991 • 161 citations

A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2

1991 • 158 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site

1990 • 156 citations

Cytomegalovirus infection enhances smooth muscle cell proliferation and intimal thickening of rat aortic allografts.

1993 • 152 citations

The presence of cytomegalovirus nucleic acids in arterial walls of atherosclerotic and nonatherosclerotic patients.

1989 • 147 citations

Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression

1993 • 140 citations

Cytomegalovirus/herpesvirus and carotid atherosclerosis: The aric study

1994 • 134 citations

Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.

1990 • 134 citations

Molecular biology and immunology of cytomegalovirus

1987 • 128 citations

The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter

1996 • 116 citations

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.

1992 • 115 citations

Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB

1995 • 114 citations

Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein

1994 • 111 citations

Cytomegalovirus nucleic acid distribution within the human vascular tree.

1991 • 110 citations

Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts

1994 • 103 citations

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter

1990 • 100 citations

Participation of two human cytomegalovirus immediate early gene regions in transcriptional activation of adenovirus promoters

1987 • 99 citations

Design of retrovirus vectors for transfer and expression of the human beta-globin gene

1988 • 96 citations

Improved method for computing potential doubling time from flow cytometric data

1990 • 95 citations

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription

1995 • 87 citations

Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus

1991 • 86 citations

Epithelial cells immortalized by human papillomaviruses have premalignant characteristics in organotypic culture.

1991 • 86 citations

Molecular Aspects of Human Cytomegalovirus Diseases

1993 • 84 citations

CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early protein

1995 • 80 citations

CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter

1996 • 79 citations

Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box

1993 • 71 citations

E2F Mediates Dihydrofolate Reductase Promoter Activation and Multiprotein Complex Formation in Human Cytomegalovirus Infection

1992 • 68 citations

The Immediate Early Genes of Human Cytomegalovirus Upregulate Expression of the Interleukin-2 and Interleukin-2 Receptor Genes

1991 • 68 citations

The Pathogenicity of Human Cytomegalovirus: An Overview

1993 • 48 citations

An isoform variant of the cytomegalovirus immediate-early auto repressor functions as a transcriptional activator

1992 • 43 citations

Epstein--Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays

1995 • 36 citations

The Retinoblastoma Gene Product Negatively Regulates Transcriptional Activation Mediated by the Human Cytomegalovirus IE2 Protein

1995 • 34 citations

Molecular Biology of Human Cytomegalovirus

1993 • 18 citations

Molecular biology of cytomegalovirus.

1990 • 7 citations

Human Cytomegalovirus and Atherogenesis

1993 • 7 citations