Inhibition of Cellular Cdk2 Activity Blocks Human Cytomegalovirus Replication

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

1994 • 625 citations

Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

1975 • 616 citations

Impact of Cytomegalovirus Infection on Organ Transplant Recipients

1990 • 452 citations

Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication

1993 • 389 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Congenital and Perinatal Cytomegalovirus Infections

1990 • 365 citations

Temporal Patterns of Human Cytomegalovirus Transcription: Mapping the Viral RNAs Synthesized at Immediate Early, Early, and Late Times After Infection

1982 • 311 citations

Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

1995 • 285 citations

Cyclin A-Associated Kinase Activity Is Rate Limiting for Entrance into S Phase and Is Negatively Regulated in G₁ by p27^Kip1

1995 • 252 citations

Chemical inhibitors of cyclin-dependent kinases

1996 • 251 citations

Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

1990 • 216 citations

Human Cytomegalovirus Inhibits Cellular DNA Synthesis and Arrests Productively Infected Cells in Late G1

1996 • 211 citations

Human cytomegalovirus infection inhibits G1/S transition

1997 • 197 citations

Early events in DNA replication require cyclin E and are blocked by p21CIP1.

1995 • 197 citations

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S

1996 • 175 citations

Activation of Proto-Oncogenes: an Immediate Early Event in Human Cytomegalovirus Infection

1990 • 170 citations

Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid

1975 • 154 citations

Stimulation of Cellular Thymidine Kinases by Human Cytomegalovirus

1977 • 141 citations

The role of E2F in the mammalian cell cycle

1993 • 136 citations

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.

1996 • 127 citations

The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter

1996 • 116 citations

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.

1992 • 115 citations

Cytomegalovirus in the Setting of Infection with Human Immunodeficiency Virus

1990 • 95 citations

Cytomegalovirus assembly protein nested gene family: four 3'-coterminal transcripts encode four in-frame, overlapping proteins

1991 • 87 citations

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription

1995 • 87 citations

Cell-activation responses to cytomegalovirus infection relationship to the phasing of CMV replication and to the induction of cellular damage.

1989 • 73 citations

Cytomegalovirus-mediated induction of antisense mRNA expression to UL44 inhibits virus replication in an astrocytoma cell line: identification of an essential gene

1995 • 65 citations

The Immediate Early Genes of Human Cytomegalovirus Upregulate Expression of the Cellular Genes myc and fos

1992 • 47 citations

Cell-Activation Responses to Cytomegalovirus Infection

1989 • 45 citations

Correlation between stimulation of host cell DNA synthesis by human cytomegalovirus and lack of expression of a subset of early virus genes

1983 • 42 citations

Heterogeneous Morphologic Features of Plaques Induced by Five Strains of Human Cytomegalovirus

1980 • 31 citations

Cellular oncogene activation by human cytomegalovirus Lack of correlation with virus infectivity and immediate early gene expression

1991 • 26 citations

Stably expressed antisense RNA to cytomegalovirus UL83 inhibits viral replication

1996 • 24 citations

Exogenous thymidine is preferentially incorporated into human cytomegalovirus DNA in infected human fibroblasts

1996 • 8 citations