Phosphorylation of the Human Cytomegalovirus 86-Kilodalton Immediate-Early Protein IE2

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis

1994 • 750 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175

1980 • 436 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

Structural analysis of the major immediate early gene of human cytomegalovirus

1984 • 342 citations

Organization and expression of the immediate early genes of human cytomegalovirus

1983 • 288 citations

Cytomegalovirus selectively blocks antigen processing and presentation of its immediate–early gene product

1996 • 287 citations

Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

1995 • 285 citations

Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1

1985 • 270 citations

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

1995 • 253 citations

Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA

1980 • 251 citations

trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus

1988 • 237 citations

Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4

1988 • 225 citations

Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter

1987 • 223 citations

Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

1990 • 216 citations

Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region

1989 • 216 citations

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains

1990 • 197 citations

Cytomegalovirus Replicates in Differentiated But Not in Undifferentiated Human Embryonal Carcinoma Cells

1984 • 196 citations

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID

1992 • 195 citations

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements.

1988 • 174 citations

The structure of the major immediate early gene of human cytomegalovirus strain AD169

1985 • 170 citations

Activation of Proto-Oncogenes: an Immediate Early Event in Human Cytomegalovirus Infection

1990 • 170 citations

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

1994 • 164 citations

Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection

1981 • 159 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Phorbol ester-induced differentiation permits productive human cytomegalovirus infection in a monocytic cell line.

1988 • 146 citations

The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear localization signal

1991 • 146 citations

Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo.

1994 • 144 citations

The DNA-Binding Properties of the Major Regulatory Protein α4 of Herpes Simplex Viruses

1988 • 144 citations

The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulation

1993 • 138 citations

The mitogen-activated protein kinases, ERK1 and ERK2.

1994 • 137 citations

Predominant immediate-early transcripts of human cytomegalovirus AD 169

1984 • 137 citations

Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene

1988 • 121 citations

Transactivation of the cytomegalovirus ICP36 gene promoter requires the alpha gene product TRS1 in addition to IE1 and IE2

1992 • 120 citations

Characterization of phosphoproteins and protein kinase activity of virions, noninfectious enveloped particles, and dense bodies of human cytomegalovirus

1986 • 118 citations

The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements

1992 • 117 citations

The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter

1996 • 116 citations

Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB

1995 • 114 citations

Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex

1994 • 114 citations

Transcriptional activation by simian virus 40 large T antigen: interactions with multiple components of the transcription complex.

1993 • 113 citations

Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein

1994 • 111 citations

Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus

1991 • 106 citations

The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site

1996 • 105 citations

Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts

1994 • 103 citations

TAF-like functions of human cytomegalovirus immediate-early proteins

1997 • 101 citations

In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins.

1993 • 92 citations

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription

1995 • 87 citations

Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins

1993 • 84 citations

Insulin Stimulation of a MEK-Dependent but ERK-Independent SOS Protein Kinase

1996 • 82 citations

Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus

1993 • 82 citations

T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123

1994 • 82 citations

Human cytomegalovirus IE86 protein interacts with promoter-bound TATA-binding protein via a specific region distinct from the autorepression domain

1993 • 81 citations

TAF-like function of SV40 large T antigen.

1996 • 81 citations

CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early protein

1995 • 80 citations

A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins

1991 • 74 citations

Induction of α-type DNA polymerases in human cytomegalovirus-infected WI-38 cells

1976 • 74 citations

Identification of a Viral Kinase That Phosphorylates Specific E2Fs and Pocket Proteins

1997 • 72 citations

Activation of second-messenger pathways reactivates latent herpes simplex virus in neuronal cultures

1992 • 71 citations

The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations

1995 • 71 citations

Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other

1997 • 68 citations

Biochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: evidence for interaction between amino- and carboxy-terminal domains

1991 • 67 citations

MAP kinase binds to the NH₂‐terminal activation domain of c‐Myc

1994 • 66 citations

In Vivo and in Vitro Analysis of Transcriptional Activation Mediated by the Human Cytomegalovirus Major Immediate-Early Proteins

1993 • 64 citations

Ras and its effectors

1996 • 61 citations

Transcriptional Activation by Simian Virus 40 Large T Antigen: Interactions with Multiple Components of the Transcription Complex

1993 • 53 citations

Immediate-early proteins of human cytomegalovirus strains AD169, Davis, and towne differ in electrophoretic mobility

1981 • 52 citations

Identification of sequence elements in the human cytomegalovirus DNA polymerase gene promoter required for activation by viral gene products

1994 • 51 citations

Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication

1996 • 50 citations

The Immediate Early Genes of Human Cytomegalovirus Upregulate Expression of the Cellular Genes myc and fos

1992 • 47 citations

Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4

1996 • 45 citations

Human cytomegalovirus virion-associated protein with kinase activity

1986 • 44 citations

An isoform variant of the cytomegalovirus immediate-early auto repressor functions as a transcriptional activator

1992 • 43 citations

The G1/S cell-cycle checkpoint in eukaryotic cells

1994 • 42 citations

Transient Activation of RAF-1, MEK, and ERK2 Coincides Kinetically with Ternary Complex Factor Phosphorylation and Immediate-Early Gene Promoter Activity In Vivo

1994 • 41 citations

Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2

1993 • 38 citations

Mutations of the Human Cytomegalovirus Immediate-Early 2 Protein Defines Regions and Amino Acid Motifs Important in Transactivation of Transcription from the HIV-1 LTR Promoter

1993 • 37 citations

Human cytomegalovirus immediate-early 2 (IE2) protein can transactivate the human hsp70 promoter by alleviation of Dr1-mediated repression

1996 • 36 citations

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell‐cycle machinery

1997 • 35 citations

Modulation of T-cell activation through protein kinase C- or A-dependent signalling pathways synergistically increases human immunodeficiency virus long terminal repeat induction by cytomegalovirus immediate-early proteins

1991 • 34 citations

A human cytomegalovirus early promoter with upstream negative and positive cis-acting elements: IE2 negates the effect of the negative element, and NF-Y binds to the positive element

1994 • 34 citations

The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA.

1991 • 31 citations

Evidence for the role of cell protein phosphorylation in human cytomegalovirus/host cell fusion

1996 • 23 citations

The human cytomegalovirus 86-kilodalton immediate-early 2 protein: synthesis as a precursor polypeptide and interaction with a 75-kilodalton protein of probable viral origin

1994 • 20 citations

Catalytic properties of a human cytomegalovirus‐induced protein kinase

1985 • 19 citations

Stimulating effect of heat shock on the early stage of human cytomegalovirus replication cycle

1986 • 18 citations

Labeling Cultured Cells with ³²P_i and Preparing Cell Lysates for Immunoprecipitation

1997 • 15 citations