Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

2005 • 2,216 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis

1994 • 750 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Pulmonary Complications of the Acquired Immunodeficiency Syndrome

1984 • 698 citations

Cyclin activation of p34cdc2

1990 • 690 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Cytomegalovirus: Biology and Infection.

1983 • 443 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.

1994 • 377 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

Comparative evaluation of several DNA binding dyes in the detection of apoptosis‐associated chromatin degradation by flow cytometry

1992 • 375 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Cyclin A is required in S phase in normal epithelial cells

1992 • 273 citations

The cdc25 M-phase inducer: An unconventional protein phosphatase

1992 • 266 citations

CYTOMEGALOVIRUS AND KAPOSI'S SARCOMA IN YOUNG HOMOSEXUAL MEN

1982 • 258 citations

Specific enzymatic dephosphorylation of the retinoblastoma protein.

1993 • 258 citations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

1992 • 239 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

1994 • 235 citations

Role for cyclin A in the dependence of mitosis on completion of DMA replication

1991 • 212 citations

Stimulation of Cellular DNA Synthesis by Human Cytomegalovirus

1974 • 197 citations

Cyclin A is required for the onset of DNA replication in mammalian fibroblasts

1992 • 185 citations

Synthesis of Proteins and Glycoproteins in Cells Infected with Human Cytomegalovirus

1977 • 184 citations

Coupling M phase and S phase: Controls maintaining the dependence of mitosis on chromosome replication

1991 • 183 citations

The retinoblastoma protein as a transcriptional repressor

1993 • 176 citations

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

1994 • 164 citations

Pulmonary complications of the acquired immunodeficiency syndrome: A clinicopathologic study of 70 cases

1985 • 146 citations

Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E.

1994 • 129 citations

The p53 tumor suppressor protein: meeting review.

1993 • 128 citations

Human cytomegalovirus stimulates host cell RNA synthesis

1975 • 118 citations

Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle.

1992 • 116 citations

Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein

1994 • 111 citations

Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts

1994 • 103 citations

Construction of a cloned library of the EcoRI fragments from the human cytomegalovirus genome (strain AD169)

1982 • 99 citations

Specific Enzymatic Dephosphorylation of the Retinoblastoma Protein

1993 • 96 citations

Diseases Produced by Cytomegaloviruses

1978 • 96 citations

In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.

1993 • 91 citations

Cell-activation responses to cytomegalovirus infection relationship to the phasing of CMV replication and to the induction of cellular damage.

1989 • 73 citations

Induction of Cellular DNA Synthesis and Increased Mitotic Activity in Syrian Hamster Embryo Cells Abortively Infected with Human Cytomegalovirus

1976 • 70 citations

Productive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells

1995 • 62 citations

Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation

1994 • 61 citations

The effects of cytomegalovirus on human immunodeficiency virus replication in brain-derived cells correlate with permissiveness of the cells for each virus

1994 • 47 citations

Analysis of simian virus 40 infection of CV‐1 cells by quantitative two‐color fluorescence with flow cytometry

1988 • 47 citations

Induction of chromosome aberrations and mitotic arrest by cytomegalovirus in human cells

1988 • 45 citations

Correlation between stimulation of host cell DNA synthesis by human cytomegalovirus and lack of expression of a subset of early virus genes

1983 • 42 citations

Human cytomegalovirus infection of WI-38 cells stimulates mitochondrial DNA synthesis

1976 • 41 citations

Stimulation of Macromolecular Synethesis in Guinea Pig Cells by Human CMV

1975 • 35 citations

The Biology of Cytomegaloviruses

1983 • 35 citations

The use of DNA probes in studies of human cytomegalovirus.

1985 • 34 citations

Simian Virus 40-Host Cell Interaction During Lytic Infection

1979 • 33 citations

Induction of host DNA synthesis and DNA polymerase by DNA-negative temperature-sensitive mutants of human cytomegalovirus

1979 • 33 citations

Simian virus 40 prevents activation of M-phase-promoting factor during lytic infection

1994 • 32 citations

Selective chromosomal damage caused by human cytomegalovirus.

1980 • 23 citations

Hypophosphorylated retinoblastoma gene product accumulates in SV40-infected CV-1 cells acquiring a tetraploid DNA content.

1993 • 20 citations

Quantitation of simian virus 40 T‐antigen correlated with the cell cycle of permissive and non‐permissive cells

1993 • 20 citations

Rabbit kidney cells abortively infected with human cytomegalovirus are arrested in mitotic phase

1986 • 19 citations

Interactions between human herpesviruses and host cell chromosomes.

1978 • 10 citations

Molecular Studies on the Cytomegaloviruses of Mice and Men

1985 • 4 citations