Induction of Nitric Oxide Synthase in Glial Cells

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Radioimmunoassay for Cyclic Nucleotides

1972 • 2,057 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

1990 • 1,012 citations

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

1989 • 912 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Intercellular signaling in glial cells: Calcium waves and oscillations in response to mechanical stimulation and glutamate

1991 • 723 citations

Nitric oxide as a neuronal messenger

1991 • 638 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Endothelial Cell Production of Nitrogen Oxides in Response to Interferon in Combination With Tumor Necrosis Factor, Interleukin-1, or Endotoxin

1990 • 474 citations

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

1990 • 455 citations

Functional receptors for neurotransmitters on astroglial cells

1987 • 436 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.

1983 • 353 citations

Astrocyte heterogeneity

1990 • 254 citations

Purification of nitric oxide synthase from rat macrophages

1991 • 244 citations

Lipopolysaccharide-free conditions in primary astrocyte cultures allow growth and isolation of microglial cells

1989 • 217 citations

Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells.

1990 • 205 citations

Evidence for an Astrocyte‐Derived Vasorelaxing Factor with Properties Similar to Nitric Oxide

1990 • 196 citations

Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells.

1991 • 192 citations

A Kainate Receptor Linked to Nitric Oxide Synthesis from Arginine

1989 • 186 citations

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

1990 • 179 citations

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

1991 • 164 citations

Pharmacologically-distinct subsets of astroglia can be identified by their calcium response to neuroligands

1991 • 156 citations

Cyclic GMP stimulates Na+/Ca2+ exchange in vascular smooth muscle cells in primary culture

1991 • 136 citations

Predominant localization in glial cells of freel-arginine. Immunocytochemical evidence

1991 • 119 citations

Receptor-mediated inositol phospholipid hydrolysis in astrocytes

1986 • 112 citations

Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.

1990 • 111 citations

Norepinephrine‐evoked calcium transients in cultured cerebral type 1 astroglia

1990 • 109 citations

Interleukin-1 β induces the production of an L-arginine-derived relaxing factor from cultured smooth muscle cells from rat aorta

1991 • 104 citations

Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells

1991 • 98 citations

Different receptors mediate stimulation of nitric oxide-dependent cyclic GMP formation in neurons and astrocytes in culture

1992 • 94 citations

A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts

1991 • 94 citations

In vitro interaction between cerebellar astrocytes and granule cells: A putative role for nitric oxide

1992 • 89 citations

Norepinephrine increases cyclic GMP in astrocytes by a mechanism dependent on nitric oxide synthesis

1991 • 47 citations

Generation of Astrocyte Cultures from Normal and Neoplastic Central Nervous System

1990 • 40 citations

Production of an EDRF‐like activity in the cytosol of N1E‐115 neuroblastoma cells

1990 • 38 citations

Central Nervous System Astroglial Cells Release Nitrogen Oxide(s) with Vasorelaxant Properties

1991 • 32 citations

Cultured astrocytoma cells inhibit platelet aggregation by releasing a nitric oxide-like factor

1990 • 29 citations