Nitric oxide-mediated neuronal injury in multiple sclerosis

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

1990 • 455 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

YELLOW NAILS AND LYMPHOEDEMA.

1964 • 370 citations

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

1992 • 312 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1.

1991 • 243 citations

Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages.

1990 • 237 citations

MS: a CNS and systematic autoimmune disease

1989 • 231 citations

Phase I-II trial of pentoxifylline for the prevention of transplant- related toxicities following bone marrow transplantation [published erratum appears in Blood 1992 Jun 15;79(12):3397] [see comments]

1991 • 200 citations

SHORT COMMUNICATION: Cytokines Induce an L-Arginine-Dependent Effector System in Nonmacrophage Cells

1988 • 133 citations

Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGFβ

1991 • 126 citations

In vitro and in vivo activation of human mononuclear phagocytes by interferon-gamma. Studies with normal and AIDS monocytes.

1987 • 124 citations

Cellular immune response in multiple sclerosis plaques.

1990 • 112 citations

T-cell-mediated activation of macrophages

1991 • 71 citations

Serum cytokine levels in chronic progressive multiple sclerosis: interleukin-2 levels parallel tumor necrosis factor-α levels

1991 • 59 citations

Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis

1991 • 55 citations

The use of protease inhibitors in experimental allergic neuritis

1991 • 26 citations

Therapeutics of Multiple Sclerosis

1991 • 15 citations

Tnf-mediated cytotoxicity. importance of intracellular cgmp level for determining tnf-sensitivity

1991 • 11 citations