S-glutathionylation in protein redox regulation

Free Radicals in the Physiological Control of Cell Function

2002 • 9,561 citations

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

2001 • 4,399 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Biomarkers of Oxidative Damage in Human Disease

2006 • 1,639 citations

Redefining Oxidative Stress

2006 • 1,587 citations

Redox Regulation of Cellular Signalling

1999 • 1,146 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide

1999 • 769 citations

Regulation of protein function by S‐glutathiolation in response to oxidative and nitrosative stress

2000 • 740 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Glutaredoxins: Glutathione-Dependent Redox Enzymes with Functions Far Beyond a Simple Thioredoxin Backup System

2004 • 643 citations

Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation

2000 • 638 citations

S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide

2004 • 623 citations

Protein Sulfenic Acids in Redox Signaling

2004 • 569 citations

Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes

2002 • 565 citations

Redox modifications of protein–thiols: Emerging roles in cell signaling

2005 • 562 citations

Redox‐dependent signal transduction

2000 • 558 citations

[2] Thiol/disulfide exchange equilibria and disulfidebond stability

1995 • 535 citations

Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

2004 • 533 citations

Antioxidant Function of Thioredoxin and Glutaredoxin Systems

2000 • 491 citations

OxyR

2002 • 459 citations

Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress

2004 • 445 citations

Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics

2004 • 439 citations

Reactive oxygen species as essential mediators of cell adhesion

2003 • 427 citations

Dynamic redox control of NF-κB through glutaredoxin-regulated S-glutathionylation of inhibitory κB kinase β

2006 • 411 citations

Protein Sulfhydryls and Their Role in the Antioxidant Function of Protein S-Thiolation

1995 • 409 citations

Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins

2004 • 391 citations

Reversible Glutathionylation of Complex I Increases Mitochondrial Superoxide Formation

2003 • 387 citations

Glutathionylation of the p50 Subunit of NF-κB: a Mechanism for Redox-Induced Inhibition of DNA Binding

2001 • 384 citations

EXTRACELLULAR THIOLS AND THIOL/DISULFIDE REDOX IN METABOLISM

2004 • 383 citations

Thiol redox control via thioredoxin and glutaredoxin systems

2005 • 380 citations

Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

2004 • 375 citations

Glutaredoxin: Role in Reversible ProteinS-Glutathionylation and Regulation of Redox Signal Transduction and Protein Translocation

2005 • 362 citations

Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems

2002 • 346 citations

Reversible Glutathionylation Regulates Actin Polymerization in A431 Cells

2001 • 335 citations

Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with πGST

2004 • 335 citations

Nitric Oxide-induced S-Glutathionylation and Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase

1999 • 316 citations

Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis

2002 • 315 citations

Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins

2004 • 310 citations

Sulfenic Acid Formation in Human Serum Albumin by Hydrogen Peroxide and Peroxynitrite

2003 • 307 citations

Thioltransferase is a specific glutathionyl mixed-disulfide oxidoreductase

1993 • 305 citations

S-Glutathiolation of Ras Mediates Redox-sensitive Signaling by Angiotensin II in Vascular Smooth Muscle Cells

2004 • 298 citations

Redox regulation of c‐Jun DNA binding by reversible S‐glutathiolation

1999 • 285 citations

S‐Glutathionylation: from redox regulation of protein functions to human diseases

2004 • 278 citations

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide

2004 • 277 citations

ReviewRegulation of protein function by glutathionylation

2005 • 262 citations

Protein thiol oxidation in health and disease: Techniques for measuring disulfides and related modifications in complex protein mixtures

2006 • 256 citations

Redox proteomics: Identification of oxidatively modified proteins

2003 • 256 citations

Identification of Cysteines Involved in S-Nitrosylation, S-Glutathionylation, and Oxidation to Disulfides in Ryanodine Receptor Type 1

2006 • 242 citations

Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation

2006 • 235 citations

Thiol–Disulfide Balance: From the Concept of Oxidative Stress to that of Redox Regulation

2005 • 235 citations

Identification of Oxidant-Sensitive Proteins: TNF-α Induces Protein Glutathiolation

2000 • 209 citations

Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain

2004 • 198 citations

[59] Glutathione disulfide (GSSG) efflux from cells and tissues

1984 • 197 citations

Reversible S-glutathionylation of Cys374 regulates actin filament formation by inducing structural changes in the actin molecule

2002 • 195 citations

Glutathionylation of chloroplast thioredoxin f is a redox signaling mechanism in plants

2005 • 189 citations

Detection and Mapping of Widespread Intermolecular Protein Disulfide Formation during Cardiac Oxidative Stress Using Proteomics with Diagonal Electrophoresis

2004 • 188 citations

A Novel Role for Human Sulfiredoxin in the Reversal of Glutathionylation

2006 • 187 citations

A Transverse Tubule NADPH Oxidase Activity Stimulates Calcium Release from Isolated Triads via Ryanodine Receptor Type 1 S -Glutathionylation

2006 • 186 citations

Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences

2007 • 186 citations

Glutathione-Thiyl Radical Scavenging and Transferase Properties of Human Glutaredoxin (Thioltransferase)

2003 • 182 citations

Regulation of cAMP-dependent Protein Kinase Activity by Glutathionylation

2002 • 180 citations

Gene expression profiling reveals a signaling role of glutathione in redox regulation

2005 • 179 citations

Detection, Quantitation, Purification, and Identification of Cardiac Proteins S-Thiolated during Ischemia and Reperfusion

2002 • 171 citations

Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines

2001 • 169 citations

Identification of proteins undergoing glutathionylation in oxidatively stressed hepatocytes and hepatoma cells

2003 • 168 citations

Direct Evidence for the Formation of a Complex between 1-Cysteine Peroxiredoxin and Glutathione S-Transferase π with Activity Changes in Both Enzymes

2005 • 167 citations

Glutathiolation Regulates Tumor Necrosis Factor-α–Induced Caspase-3 Cleavage and Apoptosis

2006 • 161 citations

Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool

2000 • 160 citations

Reversible Inactivation of α-Ketoglutarate Dehydrogenase in Response to Alterations in the Mitochondrial Glutathione Status

2003 • 160 citations

Glutathione Supplementation Potentiates Hypoxic Apoptosis by S-Glutathionylation of p65-NFκB

2007 • 159 citations

Sites and Mechanisms of Aconitase Inactivation by Peroxynitrite: Modulation by Citrate and Glutathione

2005 • 156 citations

Actin Glutathionylation Increases in Fibroblasts of Patients with Friedreich's Ataxia

2003 • 156 citations

Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of γ-glutamyl transpeptidase-dependent H2O2 production and S-thiolation

1999 • 155 citations

Redox Regulation of β-Actin during Integrin-mediated Cell Adhesion

2006 • 155 citations

The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation.

1996 • 148 citations

Molecular Mechanism of the Reduction of Cysteine Sulfinic Acid of Peroxiredoxin to Cysteine by Mammalian Sulfiredoxin

2006 • 146 citations

Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin

2003 • 145 citations

Oxidized Forms of Glutathione in Peripheral Blood as Biomarkers of Oxidative Stress

2006 • 143 citations

Regulation of Mitochondrial NADP+-dependent Isocitrate Dehydrogenase Activity by Glutathionylation

2005 • 136 citations

Oxidant-Induced S-Glutathiolation Inactivates Protein Kinase C-α (PKC-α): A Potential Mechanism of PKC Isozyme Regulation

2000 • 134 citations

Amyloid‐β induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease

2005 • 134 citations

Age-Related Influence on Thiol, Disulfide, and Protein-Mixed Disulfide Levels in Human Plasma

2006 • 130 citations

Sulfenic acid in human serum albumin

2006 • 129 citations

Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle

2005 • 128 citations

S‐glutathiolation by peroxynitrite of p21ras at cysteine‐118 mediates its direct activation and downstream signaling in endothelial cells

2006 • 126 citations

The Utility of N,N-Biotinyl Glutathione Disulfide in the Study of Protein S-Glutathiolation

2005 • 126 citations

S-Nitrosation versus S-Glutathionylation of Protein Sulfhydryl Groups by S-Nitrosoglutathione

2005 • 126 citations

Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways

2006 • 124 citations

S-Glutathionylation Decreases Mg2+ Inhibition and S-Nitrosylation Enhances Ca2+ Activation of RyR1 Channels

2003 • 122 citations

Glyceraldehyde Phosphate Dehydrogenase Oxidation During Cardiac Ischemia and Reperfusion

2002 • 120 citations

Inactivation of creatine kinase by S-glutathionylation of the active-site cysteine residue

2000 • 118 citations

Studies on the Mechanism of Oxidative Modification of Human Glyceraldehyde-3-phosphate Dehydrogenase by Glutathione: Catalysis by Glutaredoxin

1998 • 118 citations

Nitric-Oxide-Induced Vasodilatation: Regulation by Physiologic S-Glutathiolation and Pathologic Oxidation of the Sarcoplasmic Endoplasmic Reticulum Calcium ATPase

2006 • 118 citations

Protein glutathiolation by nitric oxide: an intracellular mechanism regulating redox protein modification

2006 • 116 citations

α-Adrenergic Receptor–Stimulated Hypertrophy in Adult Rat Ventricular Myocytes Is Mediated via Thioredoxin-1–Sensitive Oxidative Modification of Thiols on Ras

2005 • 115 citations

Actin S-glutathionylation: evidence against a thiol-disulphide exchange mechanism

2003 • 112 citations

Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis

2005 • 109 citations

Stress, Protein (Mis)folding, and Signaling: The Redox Connection

2004 • 106 citations

A Glutathione S-Transferase π-Activated Prodrug Causes Kinase Activation Concurrent with S-Glutathionylation of Proteins

2005 • 104 citations

Dopamine Biosynthesis Is Regulated byS-Glutathionylation

2002 • 102 citations

Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection

2002 • 101 citations

Effects ofS-Glutathionylation andS-Nitrosylation on Calmodulin Binding to Triads and FKBP12 Binding to Type 1 Calcium Release Channels

2005 • 97 citations

Irreversible Thiol Oxidation in Carbonic Anhydrase III: Protection by S-Glutathiolation and Detection in Aging Rats

2002 • 96 citations

Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation

2006 • 94 citations

Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons

2006 • 86 citations

Decline of contractility during ischemia-reperfusion injury: actin glutathionylation and its effect on allosteric interaction with tropomyosin

2005 • 84 citations

Reversible Silencing of CFTR Chloride Channels by Glutathionylation

2005 • 81 citations

Crystal structure of S‐glutathiolated carbonic anhydrase III

2000 • 81 citations

Protein S-Glutathiolation Triggered by DecomposedS-Nitrosoglutathione

2004 • 79 citations

Determination of plasma thiol bound to albumin using affinity chromatography and high-performance liquid chromatography with fluorescence detection: Ratio of cysteinyl albumin as a possible biomarker of oxidative stress

2006 • 79 citations

Novel application of S-nitrosoglutathione‒Sepharose to identify proteins that are potential targets for S-nitrosoglutathione-induced mixed-disulphide formation

2000 • 78 citations

S-Glutathiolation of p21ras by Peroxynitrite Mediates Endothelial Insulin Resistance Caused by Oxidized Low-Density Lipoprotein

2006 • 76 citations

S-glutathionylation in human platelets by a thiol–disulfide exchange-independent mechanism

2005 • 74 citations

Regulation of Annexin A2 by Reversible Glutathionylation

2004 • 74 citations

Determination of site-specificity of S-glutathionylated cellular proteins

2005 • 73 citations

Increased glutathionylated hemoglobin (HbSSG) in type 2 diabetes subjects with microangiopathy

2005 • 72 citations

Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs. S-thiolation

2000 • 72 citations

S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity

2006 • 69 citations

In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization

2006 • 68 citations

Glutathionylation Induces the Dissociation of 1-Cys D-peroxiredoxin Non-covalent Homodimer

2006 • 66 citations

Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry

2006 • 65 citations

Protein Glutathionylation in Erythrocytes

2003 • 64 citations

Protein s-glutathionylation in retinal pigment epithelium converts heat shock protein 70 to an active chaperone

2004 • 63 citations

Fast-reacting Thiols in Rat Hemoglobins Can Intercept Damaging Species in Erythrocytes More Efficiently Than Glutathione

1998 • 61 citations

Catalysis of Thiol/Disulfide Exchange

2005 • 60 citations

Reversible Cysteine-Targeted Oxidation of Proteins during Renal Oxidative Stress

2003 • 58 citations

Different types of glutathionylation of hemoglobin can exist in intact erythrocytes

2003 • 50 citations

Reversible Oxidative Modification as a Mechanism for Regulating Retroviral Protease Dimerization and Activation

2003 • 49 citations

Redox regulation of cyclophilin A by glutathionylation

2005 • 45 citations

Redox modulation of tau and microtubule-associated protein-2 by the glutathione/glutaredoxin reductase system

2004 • 44 citations

Signal Transduction and Human Disease

2003 • 40 citations

The identification of a reaction site of glutathione mixed-disulphide formation on gammaS-crystallin in human lens

2004 • 37 citations

Glutathionylation of Two Cysteine Residues in Paired Domain Regulates DNABinding Activity ofPax-8

2005 • 37 citations

Molecular Determinants ofS-Glutathionylation of Carbonic Anhydrase 3

2005 • 32 citations

Membrane skeletal protein S-glutathionylation and hemolysis in human red blood cells

2006 • 31 citations

Protein S-glutathionylation correlates to selective stress gene expression and cytoprotection

2002 • 25 citations

Plasma albumin cysteinylation is regulated by cystathionine β-synthase

2004 • 25 citations

Modulation of aldose reductase activity through S-thiolation by physiological thiols

2001 • 21 citations

Reversal of protein S-glutathiolation by glutaredoxin in the retinal pigment epithelium

2003 • 18 citations