Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways

H ₂ O ₂ , a Necessary Evil for Cell Signaling

2006 • 2,018 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

2005 • 1,373 citations

The changing faces of glutathione, a cellular protagonist

2003 • 1,305 citations

Oxidative protein folding in eukaryotes

2004 • 990 citations

The Organosulfur Chemistry of the Genus Allium – Implications for the Organic Chemistry of Sulfur

1992 • 973 citations

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

2004 • 948 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

2003 • 926 citations

A Thiol Peroxidase Is an H2O2 Receptor and Redox-Transducer in Gene Activation

2002 • 875 citations

Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide

1999 • 769 citations

Regulation of protein function by S‐glutathiolation in response to oxidative and nitrosative stress

2000 • 740 citations

Two Enzymes in One

2004 • 729 citations

Sulfur and Selenium: The Role of Oxidation State in Protein Structure and Function

2003 • 720 citations

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

2005 • 702 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

2003 • 627 citations

Degradation of Misfolded Proteins Prevents ER-Derived Oxidative Stress and Cell Death

2004 • 602 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

Redox modifications of protein–thiols: Emerging roles in cell signaling

2005 • 562 citations

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

2003 • 544 citations

Chaperone Activity with a Redox Switch

1999 • 509 citations

Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation

2001 • 441 citations

Characterization of a Mammalian Peroxiredoxin That Contains One Conserved Cysteine

1998 • 439 citations

Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II

2005 • 398 citations

Proteomics Analysis of Cellular Response to Oxidative Stress

2002 • 388 citations

Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems

2002 • 346 citations

The Oxidation State of DJ-1 Regulates its Chaperone Activity Toward α-Synuclein

2005 • 343 citations

Protein disulfide isomerase: the structure of oxidative folding

2006 • 336 citations

Trafficking in persulfides: delivering sulfur in biosynthetic pathways

2006 • 325 citations

The role of cysteine residues as redox-sensitive regulatory switches

2004 • 317 citations

Nitric Oxide-induced S-Glutathionylation and Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase

1999 • 316 citations

Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins

2004 • 310 citations

2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications

2005 • 308 citations

The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators

2005 • 306 citations

Thioltransferase is a specific glutathionyl mixed-disulfide oxidoreductase

1993 • 305 citations

Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7Å resolution

2000 • 296 citations

Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death

2005 • 293 citations

Phospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase

1999 • 287 citations

[29] Glutaredoxin

1995 • 284 citations

S‐Glutathionylation: from redox regulation of protein functions to human diseases

2004 • 278 citations

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide

2004 • 277 citations

Hypothesis: the role of reactive sulfur species in oxidative stress

2001 • 274 citations

Redox control of enzyme activities by thiol/disulfide exchange

1984 • 264 citations

Oxidative activation of antioxidant defence

2005 • 254 citations

Aging and the Role of Reactive Nitrogen Species

2002 • 244 citations

A cysteine-sulfinic acid in peroxiredoxin regulates H ₂ O ₂ -sensing by the antioxidant Pap1 pathway

2005 • 235 citations

A 2-Cys Peroxiredoxin Regulates Peroxide-Induced Oxidation and Activation of a Stress-Activated MAP Kinase

2004 • 212 citations

Hydrogen sulphide — a novel mediator of inflammation?

2006 • 209 citations

Multiple roles of cysteine in biocatalysis

2003 • 207 citations

Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes

2002 • 193 citations

Glutathionylation of Mitochondrial Proteins

2005 • 189 citations

Detection and Mapping of Widespread Intermolecular Protein Disulfide Formation during Cardiac Oxidative Stress Using Proteomics with Diagonal Electrophoresis

2004 • 188 citations

A Novel Role for Human Sulfiredoxin in the Reversal of Glutathionylation

2006 • 187 citations

S-Glutathiolated Hepatocyte Proteins and Insulin Disulfides as Substrates for Reduction by Glutaredoxin, Thioredoxin, Protein Disulfide Isomerase, and Glutathione

1996 • 186 citations

Glutathione-Thiyl Radical Scavenging and Transferase Properties of Human Glutaredoxin (Thioltransferase)

2003 • 182 citations

Activation of Matrix Metalloproteinase-2 by Overexpression of Manganese Superoxide Dismutase in Human Breast Cancer MCF-7 Cells Involves Reactive Oxygen Species

2002 • 180 citations

Gene expression profiling reveals a signaling role of glutathione in redox regulation

2005 • 179 citations

Glyceraldehyde-3-Phosphate Dehydrogenase Inactivation by Peroxynitrite

1998 • 179 citations

Folding of small disulfide-rich proteins: clarifying the puzzle

2006 • 166 citations

Regeneration of Peroxiredoxins during Recovery after Oxidative Stress

2003 • 158 citations

Oxidation of a Eukaryotic 2-Cys Peroxiredoxin Is a Molecular Switch Controlling the Transcriptional Response to Increasing Levels of Hydrogen Peroxide

2005 • 155 citations

Post‐translational modification is essential for catalytic activity of nitrile hydratase

2000 • 153 citations

Activation of the Redox-Regulated Molecular Chaperone Hsp33—A Two-Step Mechanism

2001 • 148 citations

Molecular Mechanism of the Reduction of Cysteine Sulfinic Acid of Peroxiredoxin to Cysteine by Mammalian Sulfiredoxin

2006 • 146 citations

Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide

2005 • 144 citations

Phosphorylation and concomitant structural changes in human 2‐Cys peroxiredoxin isotype I differentially regulate its peroxidase and molecular chaperone functions

2005 • 127 citations

S-Nitrosation versus S-Glutathionylation of Protein Sulfhydryl Groups by S-Nitrosoglutathione

2005 • 126 citations

Glutathione-Linked Thiol Peroxidase Activity of Human Serum Albumin: A Possible Antioxidant Role of Serum Albumin in Blood Plasma

1996 • 119 citations

Glutathionylation of proteins by glutathione disulfide S-oxide

2002 • 108 citations

Oxidation of glutathione by hydrogen peroxide and other oxidizing agents

1981 • 108 citations

Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection

2002 • 101 citations

Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen

2006 • 93 citations

Neuroferritinopathy: a neurodegenerative disorder associated with L-ferritin mutation

2005 • 83 citations

Protein misfolding disorders: Pathogenesis and intervention

2006 • 80 citations

Generation of reactive oxygen species by a persulfide (BnSSH)

2005 • 76 citations

Reactive sulphur species: an in vitro investigation of the oxidation properties of disulphide S-oxides

2002 • 75 citations

The interaction of reduced glutathione with active oxygen species generated by xanthine-oxidase-catalyzed metabolism of xanthine

1985 • 72 citations

Protein Misfolding, Aggregation, and Degradation in Disease<SUP>

2005 • 65 citations

Oxidative Damage and Aging: Spotlight on Mitochondria

2006 • 65 citations

Determination of Rate Constants of the Reactions of Thiols with Superoxide Radical by Electron Paramagnetic Resonance: Critical Remarks on Spectrophotometric Approaches

1996 • 62 citations

Structural Basis for the Retroreduction of Inactivated Peroxiredoxins by Human Sulfiredoxin^,

2005 • 59 citations

On the Origin of Cytotoxicity of the Natural Product Varacin. A Novel Example of a Pentathiepin Reaction That Provides Evidence for a Triatomic Sulfur Intermediate

2001 • 56 citations

A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection

2005 • 55 citations

Reactive Sulfur Species: Aqueous Chemistry of Sulfenyl Thiocyanates

2004 • 54 citations

Phospholipid hydroperoxide cysteine peroxidase activity of human serum albumin

1999 • 48 citations

Reactive Sulfur Species: Kinetics and Mechanism of the Oxidation of Cystine by Hypochlorous Acid to Give N,N‘-Dichlorocystine

2005 • 39 citations

Evolution of Eukaryotic Cysteine Sulfinic Acid Reductase, Sulfiredoxin (Srx), from Bacterial Chromosome Partitioning Protein ParB

2005 • 38 citations

Activation of Thiol-Dependent Antioxidant Activity of Human Serum Albumin by Alkaline pH Is Due to the B-like Conformational Change

2000 • 34 citations

Redox‐regulated chaperone function and conformational changes of Escherichia coli Hsp33

2001 • 32 citations

Oligomeric Hsp33 with Enhanced Chaperone Activity

2004 • 29 citations

Design, synthesis and glutathione peroxidase-Like properties of ovothiol-Derived diselenides

2003 • 26 citations

Protein S-glutathionylation correlates to selective stress gene expression and cytoprotection

2002 • 25 citations

Thiol-independent DNA cleavage by a leinamycin degradation product

1997 • 24 citations

Disulfide between Cys392 and Cys438 of human serum albumin is redox-active, which is responsible for the thioredoxin-supported lipid peroxidase activity

2005 • 20 citations

Phospholipid hydroperoxide cysteine peroxidase activity of human serum albumin

1999 • 19 citations

Thioredoxin-linked lipid hydroperoxide peroxidase activity of human serum albumin in the presence of palmitoyl coenzyme A

2001 • 18 citations

Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain

2006 • 15 citations

Reactive sulfur species: Reactions of hypothiocyanite

2003 • 4 citations