Thiol redox control via thioredoxin and glutaredoxin systems

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Iron-Sulfur Clusters: Nature's Modular, Multipurpose Structures

1997 • 1,810 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

2005 • 1,373 citations

Enzymatic Synthesis of Deoxyribonucleotides

1964 • 917 citations

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide.

1979 • 907 citations

Thioredoxin —a fold for all reasons

1995 • 799 citations

Iron-sulfur proteins: ancient structures, still full of surprises

2000 • 634 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

2000 • 498 citations

Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215

1999 • 492 citations

Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione.

1976 • 474 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity.

1990 • 461 citations

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

1975 • 435 citations

Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations

2000 • 418 citations

Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins

2004 • 391 citations

Cloning and Expression of a Novel Mammalian Thioredoxin

1997 • 391 citations

Reversible Glutathionylation of Complex I Increases Mitochondrial Superoxide Formation

2003 • 387 citations

Glutathionylation of the p50 Subunit of NF-κB: a Mechanism for Redox-Induced Inhibition of DNA Binding

2001 • 384 citations

Acute Cadmium Exposure Inactivates Thioltransferase (Glutaredoxin), Inhibits Intracellular Reduction of Protein-glutathionyl-mixed Disulfides, and Initiates Apoptosis

2000 • 329 citations

Cloning and Expression of a Novel Human Glutaredoxin (Grx2) with Mitochondrial and Nuclear Isoforms

2001 • 326 citations

Reduction of disulfides by thioredoxin. Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action.

1979 • 324 citations

Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria

2004 • 312 citations

Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

2001 • 306 citations

Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase

2004 • 305 citations

Bovine thioredoxin system. Purification of thioredoxin reductase from calf liver and thymus and studies of its function in disulfide reduction.

1977 • 294 citations

Redox regulation of c‐Jun DNA binding by reversible S‐glutathiolation

1999 • 285 citations

Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

1999 • 277 citations

Characterization of human glutaredoxin 2 as iron–sulfur protein: A possible role as redox sensor

2005 • 276 citations

Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14.fwdarw.S) and its mixed disulfide with glutathione

1992 • 228 citations

Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2

2001 • 223 citations

Cloning and sequencing of a human thioredoxin reductase

1995 • 211 citations

Nucleoredoxin, Glutaredoxin, and Thioredoxin Differentially Regulate NF-κB, AP-1, and CREB Activation in HEK293 Cells

2000 • 205 citations

Human mitochondrial thioredoxin reductase

1999 • 178 citations

Thioltransferase (Glutaredoxin) Reactivates the DNA-binding Activity of Oxidation-inactivated Nuclear Factor I

1998 • 161 citations

Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release

2004 • 159 citations

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide

2004 • 145 citations

Enzymatic reduction-oxidation of protein disulfides by thioredoxin

1984 • 145 citations

Glutaredoxin Protects Cerebellar Granule Neurons from Dopamine-induced Apoptosis by Activating NF-κB via Ref-1

2001 • 120 citations

Studies on the Mechanism of Oxidative Modification of Human Glyceraldehyde-3-phosphate Dehydrogenase by Glutathione: Catalysis by Glutaredoxin

1998 • 118 citations

Thioredoxin: structure and functions

1981 • 108 citations

Truncated Thioredoxin: Physiological Functions and Mechanism

2004 • 107 citations

Mass Spectrometric Analysis of Nitric Oxide-modified Caspase-3

1999 • 102 citations

Cellular and plasma levels of human glutaredoxin 1 and 2 detected by sensitive ELISA systems

2004 • 99 citations

Enzymatic reduction of disulfide bonds in fibrin-o gen by the thioredoxin system I. Identification of reduced bonds and studies on reoxidation process

1974 • 77 citations

Enzymic Reduction of Disulfide Bonds by Thioredoxin

1976 • 51 citations

Relationship of Protein-Glutathione Mixed Disulfide and Thioltransferase in H2O2-Induced Cataract in Cultured Pig Lens

1997 • 45 citations