Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1992 • 758 citations

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

1996 • 626 citations

Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis

1997 • 620 citations

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1995 • 608 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis

1991 • 518 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

Effects of peroxynitrite‐induced protein modifications on tyrosine phosphorylation and degradation

1996 • 450 citations

Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by instrastriatal injection of 6-hydroxydopamine

1995 • 435 citations

Inhibition of neuronal nitric oxide synthase prevents MPTP–induced parkinsonism in baboons

1996 • 422 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method.

1991 • 393 citations

A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics

1987 • 353 citations

Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation

1998 • 342 citations

Carbon Dioxide Enhancement of Peroxynitrite-Mediated Protein Tyrosine Nitration

1996 • 302 citations

Peroxynitrite-induced Apoptosis in HL-60 Cells

1995 • 300 citations

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

1997 • 287 citations

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1996 • 267 citations

A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal

1986 • 203 citations

Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice

1997 • 186 citations

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

1996 • 157 citations

Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP

1990 • 153 citations

Nitric oxide and peroxynitrite-mediated pulmonary cell death

1998 • 84 citations

High‐Affinity Choline Transport Sites: Use of [³H]Hemicholinium‐3 as a Quantitative Marker

1993 • 80 citations

Peroxynitrite‐Mediated Inhibition of DOPA Synthesis in PC12 Cells

1995 • 79 citations

Redox cycling of MPP+: Evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase

1993 • 65 citations

Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase

1993 • 64 citations

Change of tyrosine hydroxylase in the parkinsonian brain and in the brain of MPTP-treated mice as revealed by homospecific activity

1990 • 36 citations

Catalytic core of rat tyrosine hydroxylase: terminal deletion analysis of bacterially expressed enzyme

1994 • 26 citations

Inactivation of tyrosine hydroxylase in rat striatum by 1-methyl-4-phenylpyridinium ion (MPP+)

1988 • 25 citations

Predicted Amino Acid Sequence of Bovine Tyrosine Hydroxylase and Its Similarity to Tyrosine Hydroxylases from Other Species

1988 • 21 citations

Measurement of tyrosine hydroxylase apoenzyme protein by enzyme-linked immunosorbent assay (ELISA): Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal tyrosine hydroxylase activity and content

1991 • 10 citations

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