Guilt by association? p53 and the development of aneuploidy in cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Surfing the p53 network

2000 • 6,487 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

From polyploidy to aneuploidy, genome instability and cancer

2004 • 798 citations

Human papillomavirus immortalization and transformation functions

2002 • 758 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Centrosome aberrations: cause or consequence of cancer progression?

2002 • 725 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

Centrosome amplification drives chromosomal instability in breast tumor development

2002 • 564 citations

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

2004 • 552 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

Dissecting p53 tumor suppressor functions in vivo

2002 • 491 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.

1996 • 470 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

Evolution of neoplastic cell lineages in Barrett oesophagus

1999 • 448 citations

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1998 • 445 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.

1996 • 358 citations

Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein.

1996 • 329 citations

Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7

2001 • 312 citations

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

2003 • 307 citations

Apoptosis and genomic instability

2004 • 284 citations

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

1995 • 280 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

G1 tetraploidy checkpoint and the suppression of tumorigenesis

2002 • 226 citations

Kaposi's Sarcoma–Associated Herpesvirus Immunoevasion and Tumorigenesis: Two Sides of the Same Coin?

2003 • 215 citations

The mitotic machinery as a source of genetic instability in cancer

1999 • 201 citations

Cell cycle progression after cleavage failure

2004 • 201 citations

Genomic instability and apoptosis are frequent in p53 deficient young mice

1997 • 197 citations

Targeted inactivation of p53 in human cells does not result in aneuploidy.

2002 • 188 citations

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

2002 • 186 citations

Loss of p53 and centrosome hyperamplification

2002 • 184 citations

Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells

2004 • 183 citations

p21^Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

1999 • 171 citations

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

1998 • 168 citations

Transformation of normal human cells in the absence of telomerase activation

2002 • 154 citations

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo

2002 • 149 citations

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

2000 • 145 citations

17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy.

1994 • 142 citations

17p allelic deletions and p53 protein overexpression in Barrett's adenocarcinoma.

1991 • 138 citations

C-myc overexpression and p53 loss cooperate to promote genomic instability

1999 • 137 citations

Derivation of human tumor cells in vitro without widespread genomic instability.

2001 • 126 citations

p53 Displacement from Centrosomes and p53-mediated G1 Arrest following Transient Inhibition of the Mitotic Spindle

2001 • 123 citations

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

2004 • 119 citations

Synergy between the Mos/Mitogen-Activated Protein Kinase Pathway and Loss of p53 Function in Transformation and Chromosome Instability

1997 • 119 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 116 citations

Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes

1994 • 116 citations

Centrosome abnormalities, genomic instability and carcinogenic progression

2001 • 115 citations

Centrosomes and cancer

1999 • 113 citations

p53-Independent Apoptosis and p53-Dependent Block of DNA Rereplication Following Mitotic Spindle Inhibition in Human Cells

1999 • 104 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 100 citations

A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53‐null mammary epithelial cell mode.

2000 • 94 citations

Increased Tumor Proliferation and Genomic Instability without Decreased Apoptosis in MMTV-ras Mice Deficient in p53

1997 • 93 citations

p53 Localizes to the Centrosomes and Spindles of Mitotic Cells in the Embryonic Chick Epiblast, Human Cell Lines, and a Human Primary Culture: An Immunofluorescence Study

2000 • 78 citations

Progesterone facilitates chromosome instability (aneuploidy) in p53 null

2000 • 76 citations

Centrosomes and cancer

1999 • 76 citations

The Role of p53 in Suppression of KSHV Cyclin-induced Lymphomagenesis

2004 • 75 citations

Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint

2004 • 70 citations

Triggering p53 after cytokinesis failure

2004 • 59 citations

Selective Inactivation of p53 Facilitates Mouse Epithelial Tumor Progression without Chromosomal Instability

2001 • 57 citations

Difference in the centrosome duplication regulatory activity among p53 ‘hot spot’ mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53

2001 • 55 citations

Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses.

1997 • 50 citations

Virally transformed cells and cytochalasin B

1974 • 42 citations

Inactivation of p53 and the Development of Tetraploidy in the Elastase-SV40 T Antigen Transgenic Mouse Pancreas

1995 • 38 citations

Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis

2001 • 26 citations

Acquisition of multiple copies of a mutant topoisomerase IIα allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines

1995 • 16 citations