Acquisition of multiple copies of a mutant topoisomerase IIα allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

Mitotic stability of yeast chromosomes: A colony color assay that measures nondisjunction and chromosome loss

1985 • 486 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

DNA Topoisomerase II Must Act at Mitosis To Prevent Nondisjunction and Chromosome Breakage

1989 • 302 citations

Biochemical basis for the interactions of type I and type II topoisomerases with DNA

1989 • 251 citations

Catalytic function of DNA topoisomerase II

1991 • 246 citations

Yeast DNA topoisomerase II is encoded by a single-copy, essential gene

1984 • 175 citations

Inhibitors of DNA topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis.

1991 • 174 citations

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II

1992 • 171 citations

DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage.

1989 • 167 citations

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

1992 • 166 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1991 • 163 citations

A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.

1993 • 152 citations

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.

1991 • 149 citations

Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast.

1993 • 136 citations

Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.

1993 • 115 citations

[35] Strategies for mapping and cloning macroregions of mammalian genomes

1987 • 112 citations

Unknotting the Complexities of Multidrug Resistance: The Involvement of DNA Topoisomerases in Drug Action and Resistance

1989 • 107 citations

Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II

1992 • 94 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

Co-amplification of erbB2, topoisomerase II α and retinoic acid receptor α genes in breast cancer and allelic loss at topoisomerase I on chromosome 20

1993 • 73 citations

Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.

1992 • 72 citations

Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line.

1993 • 68 citations

The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.

1993 • 61 citations

Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26

1991 • 55 citations

A Novel Mutant Topoisomerase II.alpha. Present in VP-16-Resistant Human Melanoma Cell Lines Has a Deletion of Alanine 429

1994 • 33 citations

Conditional expression of wild-type topoisomerase II complements a mutant enzyme in mammalian cells

1993 • 24 citations

Amplification of the topoisomerase ii α gene in a non‐small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase ii α and β loci in normal tissue

1992 • 23 citations

Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II

1993 • 20 citations

Cosmid 128 defines three RFLPs on chromosome 17q23-qter. [HGM9 no. D17S77]

1988 • 5 citations