Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

Central nervous system control of food intake

2000 • 6,305 citations

TheGPR54Gene as a Regulator of Puberty

2003 • 2,419 citations

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

2003 • 2,313 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Gut hormone PYY3-36 physiologically inhibits food intake

2002 • 2,263 citations

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54

2005 • 1,187 citations

A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse

2004 • 1,106 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

2005 • 985 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates

2005 • 857 citations

A Novel Avian Hypothalamic Peptide Inhibiting Gonadotropin Release

2000 • 791 citations

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

1999 • 603 citations

Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene

2007 • 575 citations

KiSS-1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse

2006 • 540 citations

Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition

2005 • 535 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

1992 • 533 citations

Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals

2006 • 529 citations

Kiss1 −/− Mice Exhibit More Variable Hypogonadism than Gpr54−/− Mice

2007 • 521 citations

Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

2006 • 487 citations

Discovery of a receptor related to the galanin receptors

1999 • 479 citations

Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis

2004 • 472 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

Genetic approaches to studying energy balance: perception and integration

2002 • 401 citations

Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat

2006 • 374 citations

Novel signals for the integration of energy balance and reproduction

2006 • 365 citations

Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation

2009 • 359 citations

Hypothalamic pathways linking energy balance and reproduction

2008 • 344 citations

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

2007 • 329 citations

Distribution and Postnatal Development of Gpr54 Gene Expression in Mouse Brain and Gonadotropin-Releasing Hormone Neurons

2009 • 294 citations

RFamide-Related Peptide-3, a Mammalian Gonadotropin-Inhibitory Hormone Ortholog, Regulates Gonadotropin-Releasing Hormone Neuron Firing in the Mouse

2009 • 281 citations

Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat

1997 • 262 citations

Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels

2008 • 257 citations

Regulation of Hypothalamic Expression of KiSS-1 and GPR54 Genes by Metabolic Factors: Analyses Using Mouse Models and a Cell Line

2007 • 254 citations

Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin

2001 • 244 citations

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

2006 • 240 citations

Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels

2008 • 232 citations

Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel Transgenic Mouse Expressing StrongRenillaGreen Fluorescent Protein in NPY Neurons

2009 • 215 citations

Immunohistochemical evidence for synaptic connections between pro-opiomelanocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat

1988 • 207 citations

Gonadotrophin‐Releasing Hormone Pulse Generator Activity in the Hypothalamus of the Goat

2009 • 198 citations

Neuropeptide Y-Mediated Inhibition of Proopiomelanocortin Neurons in the Arcuate Nucleus Shows Enhanced Desensitization in ob/ob Mice

2004 • 197 citations

A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH): Biosynthesis, mode of action and functional significance

2009 • 191 citations

Morphological Evidence for Direct Interaction between Arcuate Nucleus Neuropeptide Y (NPY) Neurons and Gonadotropin-Releasing Hormone Neurons and the Possible Involvement of NPY Y1 Receptors1

1999 • 186 citations

Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis

2003 • 186 citations

Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat

2009 • 185 citations

Now you see it...

2002 • 181 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin

1992 • 172 citations

KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications

2008 • 161 citations

Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2‐gonadotropin‐releasing hormone neurons via a direct postsynaptic mechanism

2009 • 157 citations

GABA Release from Proopiomelanocortin Neurons

2004 • 148 citations

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels

2009 • 148 citations

Hypocretin/Orexin Innervation and Excitation of Identified Septohippocampal Cholinergic Neurons

2004 • 141 citations

Beta‐endorphin and gonadotropin‐releasing hormone synaptic input to gonadotropin‐releasing hormone neurosecretory cells in the male rat

1989 • 140 citations

KiSS-1 expression and metastin-like immunoreactivity in the rat brain

2004 • 138 citations

Lithium-Calcium Exchange Is Mediated by a Distinct Potassium-independent Sodium-Calcium Exchanger

2004 • 136 citations

Measurement of reversal potential of Na+‐Ca2+ exchange current in single guinea‐pig ventricular cells.

1989 • 136 citations

KiSS-1 and Reproduction: Focus on Its Role in the Metabolic Regulation of Fertility

2006 • 131 citations

The neuroanatomy of the kisspeptin system in the mammalian brain

2008 • 130 citations

Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks

2005 • 127 citations

KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake

2007 • 126 citations

Quantal analysis of EPSCs recorded from small numbers of synapses in hippocampal cultures

1995 • 125 citations

Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons

2008 • 119 citations

Peptide YY_3-36Inhibits Both Anorexigenic Proopiomelanocortin and Orexigenic Neuropeptide Y Neurons: Implications for Hypothalamic Regulation of Energy Homeostasis

2005 • 113 citations

Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats

2004 • 102 citations

The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels

2007 • 93 citations

Kisspeptin Increases γ-Aminobutyric Acidergic and Glutamatergic Transmission Directly to Gonadotropin-Releasing Hormone Neurons in an Estradiol-Dependent Manner

2009 • 92 citations

Morphological evidence for neuronal regulation of luteinizing hormone-releasing hormone-containing neurons by neuropeptide Y in the rat septo-preoptic area

1990 • 92 citations

Central injection in rats of α-melanocyte-stimulating hormone analog: effects on food intake and brain Fos

1998 • 88 citations

The Melanocortin 4 Receptor Mediates Leptin Stimulation of Luteinizing Hormone and Prolactin Surges in Steroid-Primed Ovariectomized Rats

1999 • 87 citations

Short-Term Starvation Decreases POMC mRNA but Does Not Alter GnRH mRNA in the Brain of Adult Male Rats

1992 • 77 citations

Attenuation of Luteinizing Hormone Surges in Neuropeptide Y Knockout Mice

2000 • 75 citations

Comparison of the effects of peripherally administered kisspeptins

2008 • 73 citations

Vasopressin Increases Locomotion through a V1a Receptor in Orexin/Hypocretin Neurons: Implications for Water Homeostasis

2008 • 67 citations

Central administration of antisense oligodeoxynucleotides to neuropeptide Y (NPY) mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release

1995 • 63 citations

Excitation of Histaminergic Tuberomamillary Neurons by Thyrotropin-Releasing Hormone

2009 • 63 citations

Characterization of SN-6, a novel Na+/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes

2007 • 61 citations

Morphological Evidence for Direct Interaction between Arcuate Nucleus Neuropeptide Y (NPY) Neurons and Gonadotropin-Releasing Hormone Neurons and the Possible Involvement of NPY Y1 Receptors

1999 • 54 citations

Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons

2007 • 54 citations

Innervation of Gonadotropin-Releasing Hormone Neurons by Peptidergic Neurons Conveying Circadian or Energy Balance Information in the Mouse

2009 • 52 citations

Neuroendocrine Proopiomelanocortin Neurons Are Excited by Hypocretin/Orexin

2009 • 51 citations

The orexigenic effect of GnIH is mediated by central opioid receptors in chicks

2008 • 44 citations

Expression of Melanocortin MC3 and MC4 Receptor mRNAs by Neuropeptide Y Neurons in the Rat Arcuate Nucleus

2005 • 43 citations

Cancer Metastasis–Suppressing Peptide Metastin Upregulates Excitatory Synaptic Transmission in Hippocampal Dentate Granule Cells

2005 • 40 citations

Group I metabotropic glutamate receptor‐dependent TRPC channel trafficking in hippocampal neurons

2006 • 40 citations

A Possible Role of Neuropeptide Y as a Mediator of Undernutrition to the Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator in Goats*

2001 • 38 citations

Group I mGluR Activation Enhances Ca²⁺-Dependent Nonselective Cation Currents and Rhythmic Bursting in Main Olfactory Bulb External Tufted Cells

2009 • 32 citations

Interconnection between orexigenic neuropeptide Y- and anorexigenic α-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus

2006 • 29 citations

Pro-opiomelanocortin and weight regulation: from mice to men.

2001 • 28 citations

Kisspeptin: A Novel Regulator of Reproductive Function

2008 • 25 citations

α MELANOCYTE STIMULATING HORMONE INDUCES GONADOTROPIN RELEASE

1981 • 24 citations

A Possible Role of Neuropeptide Y as a Mediator of Undernutrition to the Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator in Goats

2001 • 23 citations

Activation of melanocortin receptors accelerates the gonadotropin-releasing hormone pulse generator activity in goats

2005 • 14 citations

Our Evolving Understanding of Peptides and the Control of Food Intake

2006 • 1 citations