Genetic approaches to studying energy balance: perception and integration

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A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Obesity and insulin resistance

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Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

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A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

2001 • 2,865 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Ghrelin Enhances Appetite and Increases Food Intake in Humans

2001 • 2,330 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

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daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

The Leptin Receptor

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Hypothalamic CART is a new anorectic peptide regulated by leptin

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NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

From Lesions to Leptin

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Mice lacking melanin-concentrating hormone are hypophagic and lean

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Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

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Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

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Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

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Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. elegans

1998 • 804 citations

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

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Conditional control of gene expression in the mouse

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Effects of gender, body composition, and menopause on plasma concentrations of leptin.

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Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic

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A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 677 citations

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

1997 • 670 citations

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

1995 • 649 citations

Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates.

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Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

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Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.

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Key enzyme in leptin-induced anorexia

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Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

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1992 • 533 citations

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

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Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses

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Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus*

1997 • 488 citations

Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine

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A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.

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Localization of insulin receptor mRNA in rat brain by in situ hybridization

1990 • 442 citations

Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M ₃ subtype

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Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain

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Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

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Altered striatal function in a mutant mouse lacking D1A dopamine receptors.

1994 • 350 citations

Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

1999 • 347 citations

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

1998 • 347 citations

Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice

2001 • 345 citations

Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

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α-Melanocyte-Stimulating Hormone Is Contained in Nerve Terminals Innervating Thyrotropin-Releasing Hormone-Synthesizing Neurons in the Hypothalamic Paraventricular Nucleus and Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Gene Expression

2000 • 304 citations

Behavioral characterization of neuropeptide Y knockout mice

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The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight

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Role of the CNS Melanocortin System in the Response to Overfeeding

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Leptin Regulates Prothyrotropin-releasing Hormone Biosynthesis

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Association of Cocaine- and Amphetamine-Regulated Transcript-Immunoreactive Elements with Thyrotropin-Releasing Hormone-Synthesizing Neurons in the Hypothalamic Paraventricular Nucleus and Its Role in the Regulation of the Hypothalamic–Pituitary–Thyroid Axis during Fasting

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Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin**This work was supported by grants from the NIH (DK-12829, DK-52989, and NS-32272) and by the Royalty Research Fund, the Diabetes Endocrinology Research Center, and the Clinical Nutrition Research Unit of the University of Washington.

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Viral Gene Delivery Selectively Restores Feeding and Prevents Lethality of Dopamine-Deficient Mice

1999 • 127 citations

Agouti-Related Protein Containing Nerve Terminals Innervate Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus*

1999 • 120 citations

Mode of action of OB protein (leptin) on feeding

1998 • 118 citations

A Novel Homozygous Missense Mutation of Melanocortin-4 Receptor (MC4R) in a Japanese Woman With Severe Obesity

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On a Modified Mendelian Ratio Among Yellow Mice

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Insulin responses and glucose levels in plasma and cerebrospinal fluid during fasting and refeeding in the rat

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Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding

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Deletion of CCK₂Receptor in Mice Results in an Upregulation of the Endogenous Opioid System

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Attenuation of Diabetic Hyperphagia in Neuropeptide Y–Deficient Mice

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Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons

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1986 • 58 citations

The melanotropins: Chemistry, physiology and mechanism of action

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Effect of β-adrenoceptor activation on [Ca²⁺]_iregulation in murine skeletal myotubes

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Energy Metabolism and Turnover Are Increased in Mice Lacking the Cholecystokinin-B Receptor

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Insulin binding in the hypothalamus of lean and genetically obese Zucker rats

1989 • 32 citations

Molecular Pharmacology of Agouti Protein in Vitro and in Vivo

1999 • 30 citations