KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Recombinant Human Leptin in Women with Hypothalamic Amenorrhea

2004 • 877 citations

Genetics of Obesity in Humans

2006 • 561 citations

Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms

1999 • 542 citations

KiSS-1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse

2006 • 540 citations

Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition

2005 • 535 citations

Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54

2004 • 459 citations

Neuroendocrine Regulation and Actions of Leptin

1999 • 388 citations

Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control

2003 • 385 citations

Novel signals for the integration of energy balance and reproduction

2006 • 365 citations

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

2007 • 329 citations

Regulation of Hypothalamic Expression of KiSS-1 and GPR54 Genes by Metabolic Factors: Analyses Using Mouse Models and a Cell Line

2007 • 254 citations

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

2006 • 240 citations

Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats.

1993 • 202 citations

Leptin in male reproduction: the testis paradigm

2002 • 200 citations

Genetic factors in human obesity

2007 • 185 citations

Ghrelin effects on gonadotropin secretion in male and female rats

2004 • 174 citations

A role for kisspeptin in islet function

2006 • 157 citations

Effects of Chronic Hyperghrelinemia on Puberty Onset and Pregnancy Outcome in the Rat

2005 • 142 citations

Roles of Ghrelin and Leptin in the Control of Reproductive Function

2007 • 139 citations

KiSS-1 and Reproduction: Focus on Its Role in the Metabolic Regulation of Fertility

2006 • 131 citations

KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake

2007 • 126 citations

Effects of Single or Repeated Intravenous Administration of Kisspeptin upon Dynamic LH Secretion in Conscious Male Rats

2006 • 120 citations

Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis

2006 • 81 citations

Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-induced LH secretion only under conditions leading to preovulatory LH surges.

1992 • 77 citations

Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats

1993 • 62 citations

Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas

2007 • 55 citations

Effects of Polypeptide YY_3–36upon Luteinizing Hormone-Releasing Hormone and Gonadotropin Secretion in Prepubertal Rats:In Vivoandin VitroStudies

2004 • 49 citations

Neuromedin S as Novel Putative Regulator of Luteinizing Hormone Secretion

2006 • 48 citations

Central Insulin-Like Growth Factor 1 Receptors Play Distinct Roles in the Control of Reproduction, Food Intake, and Body Weight in Female Rats1

2007 • 48 citations

Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty

2006 • 33 citations

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod

2007 • 28 citations

Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone- induced LH secretion only under conditions leading to preovulatory LH surges

1992 • 25 citations

Will leptin become the treatment of choice for functional hypothalamic amenorrhea?

2007 • 16 citations