Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons

TheGPR54Gene as a Regulator of Puberty

2003 • 2,419 citations

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

2003 • 2,313 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

2001 • 1,472 citations

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

2001 • 1,406 citations

The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse

2001 • 1,218 citations

A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse

2004 • 1,106 citations

Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

2005 • 1,038 citations

KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene

1996 • 1,013 citations

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

2005 • 985 citations

AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1

2001 • 881 citations

Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons

2006 • 816 citations

The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

2003 • 655 citations

Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

2006 • 487 citations

Involvement of Central Metastin in the Regulation of Preovulatory Luteinizing Hormone Surge and Estrous Cyclicity in Female Rats

2005 • 485 citations

Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis

2004 • 472 citations

Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54

2004 • 459 citations

Olfactory Inputs to Hypothalamic Neurons Controlling Reproduction and Fertility

2005 • 422 citations

GABA- and Glutamate-Activated Channels in Green Fluorescent Protein-Tagged Gonadotropin-Releasing Hormone Neurons in Transgenic Mice

1999 • 415 citations

Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1.

1997 • 368 citations

Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol

2007 • 334 citations

Feedback Loops Link Odor and Pheromone Signaling with Reproduction

2005 • 323 citations

Physiological and Molecular Characteristics of Rat Hypothalamic Ventromedial Nucleus Glucosensing Neurons

2004 • 308 citations

Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges

2005 • 292 citations

Two Novel Missense Mutations in G Protein-Coupled Receptor 54 in a Patient with Hypogonadotropic Hypogonadism

2005 • 283 citations

Genetic Targeting of Green Fluorescent Protein to Gonadotropin-Releasing Hormone Neurons: Characterization of Whole-Cell Electrophysiological Properties and Morphology

2000 • 274 citations

Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels

2008 • 257 citations

Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels

2008 • 232 citations

Gonadotropin-releasing hormone (GnRH) neurons and pathways in the rat brain

1984 • 219 citations

Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory

2000 • 179 citations

Profiling neurotransmitter receptor expression in mouse gonadotropin-releasing hormone neurons using green fluorescent protein-promoter transgenics and microarrays

2005 • 173 citations

Combined Retrograde Tracing and Immunocytochemical Identification of Luteinizing Hormone-Releasing Hormone- and Somatostatin-Containing Neurons Projecting to the Median Eminence of the Rat*

1989 • 161 citations

Endogenous GABA Release Inhibits the Firing of Adult Gonadotropin-Releasing Hormone Neurons

2003 • 149 citations

RGS4 Inhibits Signaling by Group I Metabotropic Glutamate Receptors

1998 • 146 citations

Prefrontal Cortex–Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal

2006 • 143 citations

Hypocretin/Orexin Innervation and Excitation of Identified Septohippocampal Cholinergic Neurons

2004 • 141 citations

KiSS-1 expression and metastin-like immunoreactivity in the rat brain

2004 • 138 citations

KiSS-1 and Reproduction: Focus on Its Role in the Metabolic Regulation of Fertility

2006 • 131 citations

Postnatal Remodeling of Dendritic Structure and Spine Density in Gonadotropin-Releasing Hormone Neurons

2006 • 128 citations

Biocytin Filling of Adult Gonadotropin-Releasing Hormone Neuronsin SituReveals Extensive, Spiny, Dendritic Processes

2004 • 126 citations

Muscarinic Tone Sustains Impulse Flow in the Septohippocampal GABA But Not Cholinergic Pathway: Implications for Learning and Memory

2000 • 124 citations

Hypocretin Increases Impulse Flow in the Septohippocampal GABAergic Pathway: Implications for Arousal via a Mechanism of Hippocampal Disinhibition

2002 • 116 citations

Heterogeneity in the Basic Membrane Properties of Postnatal Gonadotropin-Releasing Hormone Neurons in the Mouse

2001 • 101 citations

The role of KiSS-1 in the regulation of puberty in higher primates

2006 • 97 citations

Agouti-Related Peptide and MC3/4 Receptor Agonists Both Inhibit Excitatory Hypothalamic Ventromedial Nucleus Neurons

2008 • 77 citations

Parvalbumin-immunoreactive, fast-spiking neurons in the medial septum/diagonal band complex of the rat: intracellular recordings in vitro

1999 • 76 citations

Major sex differences in non-genomic estrogen actions on intracellular signaling in mouse brain in vivo

2005 • 71 citations

Expression of Vesicular Glutamate Transporter-2 in Gonadotropin-Releasing Hormone Neurons of the Adult Male Rat

2004 • 69 citations

Nicotine recruits a local glutamatergic circuit to excite septohippocampal GABAergic neurons

2003 • 64 citations

Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release

2004 • 56 citations

Noradrenaline induces IPSCs in rat medial septal/diagonal band neurons: involvement of septohippocampal GABAergic neurons.

1996 • 46 citations

Selective in vivo fluorescence labelling of cholinergic neurons containing p75NTR in the rat basal forebrain

1998 • 44 citations

Cancer Metastasis–Suppressing Peptide Metastin Upregulates Excitatory Synaptic Transmission in Hippocampal Dentate Granule Cells

2005 • 40 citations

Excitatory Amino Acids Act on the Median Eminence Nerve Terminals to Induce Gonadotropin-Releasing Hormone Release in Female Rats

1998 • 39 citations

Group I Metabotropic Glutamate Receptor Activation Produces a Direct Excitation of Identified Septohippocampal Cholinergic Neurons

2004 • 34 citations

Access of luteinizing hormone-releasing hormone neurons to the vasculature in the rat

1990 • 34 citations

Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats

2003 • 34 citations

Immunocytochemical localization of the gonadotropin-releasing hormone-associated peptide portion of the LHRH precursor in the hypothalamus and extrahypothalamic regions of the rat central nervous system

1989 • 22 citations

Dual projections of gonadotropin releasing hormone containing neurons to the interpeduncular nucleus and to the vasculature in the female rat

1991 • 19 citations

Intravenous injection of evans blue labels magnocellular neuroendocrine cells of the rat supraoptic nucleusin situ and after dissociation

1992 • 19 citations

A KiSS to remember

2005 • 19 citations

A tubular configuration of the granular endoplasmic reticulum forming a raft-like parallel array in the pinealocytes of two species of Japanese moles (Mogera kobeae and M. wogura)

1984 • 16 citations

Gonadotropin-releasing hormone (GnRH) neurons in the hypogonadal mouse elaborate normal projections despite their biosynthetic deficiency

1993 • 15 citations