Intracellular calcium strongly potentiates agonist-activated TRPC5 channels

Single-Channel Recording

1995 • 2,565 citations

TRP Channels

2007 • 1,753 citations

AN INTRODUCTION TO TRP CHANNELS

2005 • 1,512 citations

Characteristics of the Cholecystokinin-Induced Depolarization of Pacemaking Activity in Cultured Interstitial Cells of Cajal from Murine Small Intestine

2013 • 1,378 citations

Vesicle Pools and Ca2+ Microdomains: New Tools for Understanding Their Roles in Neurotransmitter Release

1998 • 1,021 citations

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

2004 • 992 citations

The Life Cycle of Ca2+ Ions in Dendritic Spines

2002 • 741 citations

TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain

2001 • 737 citations

Subunit composition of mammalian transient receptor potential channels in living cells

2002 • 729 citations

Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons

1996 • 563 citations

The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms

1995 • 549 citations

Rapid vesicular translocation and insertion of TRP channels

2004 • 535 citations

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling

2007 • 511 citations

Direct activation of the ion channel TRPA1 by Ca2+

2007 • 483 citations

Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Brain

2003 • 428 citations

Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5

2000 • 422 citations

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

2008 • 387 citations

TRPC5 is a regulator of hippocampal neurite length and growth cone morphology

2003 • 377 citations

Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1

2003 • 354 citations

The molecular basis for calcium-dependent axon pathfinding

2006 • 323 citations

Transient Receptor Potential Channel A1 Is Directly Gated by Calcium Ions

2007 • 311 citations

TRPV1 shows dynamic ionic selectivity during agonist stimulation

2008 • 309 citations

A novel capacitative calcium entry channel expressed in excitable cells

1998 • 308 citations

Ca2+/Calmodulin Modulates TRPV1 Activation by Capsaicin

2003 • 305 citations

Phospholipase C in Living Cells

2005 • 298 citations

Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain

1998 • 294 citations

Regulation of the Ca2+ Sensitivity of the Nonselective Cation Channel TRPM4

2004 • 284 citations

Intrinsic Voltage Dependence and Ca2+ Regulation of mslo Large Conductance Ca-activated K+ Channels

1997 • 280 citations

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

2008 • 270 citations

Lanthanides Potentiate TRPC5 Currents by an Action at Extracellular Sites Close to the Pore Mouth

2003 • 260 citations

Ca2+-dependent Potentiation of the Nonselective Cation Channel TRPV4 Is Mediated by a C-terminal Calmodulin Binding Site

2003 • 223 citations

Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor

1996 • 220 citations

Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein

1990 • 217 citations

Calmodulin Regulation of Drosophila Light-Activated Channels and Receptor Function Mediates Termination of the Light Response In Vivo

1997 • 192 citations

Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells

2004 • 190 citations

T-jump study of calcium binding kinetics of calcium chelators

1997 • 186 citations

Multiple roles of calmodulin and other Ca2+-binding proteins in the functional regulation of TRP channels

2005 • 185 citations

Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells

1998 • 172 citations

Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate

2008 • 164 citations

Intracellular calcium ions modulate acetylcholine‐induced inward current in guinea‐pig ileum.

1990 • 158 citations

Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat-gated Ion Channel, TRPV3

2005 • 157 citations

Corticolimbic Expression of TRPC4 and TRPC5 Channels in the Rodent Brain

2007 • 156 citations

Regulation of the Mouse Epithelial Ca2+ Channel TRPV6 by the Ca2+-sensor Calmodulin

2004 • 150 citations

TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach

2003 • 146 citations

Micromolar Ca2+ transients in dendritic spines of hippocampal pyramidal neurons in brain slice

1995 • 143 citations

Regulation of the Transient Receptor Potential Channel TRPM2 by the Ca2+ Sensor Calmodulin

2006 • 128 citations

Effect of membrane potential on acetylcholine‐induced inward current in guinea‐pig ileum.

1990 • 121 citations

Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations

2008 • 116 citations

Functional Differences between TRPC4 Splice Variants

2002 • 102 citations

Calcium‐sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth

2006 • 99 citations

Calmodulin and Calcium Interplay in the Modulation of TRPC5 Channel Activity

2005 • 94 citations

Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca²⁺ Transients Mediated by L-Type Calcium Channels

2008 • 86 citations

TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin‐binding phosphoprotein‐50 (EBP50)

2004 • 79 citations

Desensitization of canonical transient receptor potential channel 5 by protein kinase C

2005 • 77 citations

Receptor-operated cation channels formed by TRPC4 and TRPC5

2005 • 76 citations

A Cytosolic Residue Mediates Mg²⁺Block and Regulates Inward Current Amplitude of a Transient Receptor Potential Channel

2005 • 74 citations

Differential distribution of TRP Ca2+ channel isoforms in mouse brain.

1998 • 74 citations

TRPC4 Is an Essential Component of the Nonselective Cation Channel Activated by Muscarinic Stimulation in Mouse Visceral Smooth Muscle Cells

2005 • 72 citations

Ca²⁺–calmodulin‐dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells

2005 • 71 citations

Interaction of Calmodulin with the Serotonin 5-Hydroxytryptamine2A Receptor

2005 • 71 citations

Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes

2005 • 62 citations

A Calcium-Activated Nonselective Cation Conductance Underlies the Plateau Potential in Rat Substantia Nigra GABAergic Neurons

2007 • 62 citations

G‐protein control of voltage dependence as well as gating of muscarinic metabotropic channels in guinea‐pig ileum.

1994 • 59 citations

Inhibition of Calmodulin-Activated Smooth-Muscle Myosin Light-Chain Kinase by Calmodulin-Binding Peptides and Fluorescent (Phosphodiesterase-Activating) Calmodulin Derivatives

1998 • 56 citations

Stimulation of phospholipase Cβ by membrane interactions, interdomain movement, and G protein binding — How many ways can you activate an enzyme?

2007 • 55 citations

Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current

2007 • 51 citations

Desensitization and Internalization of Metabotropic Glutamate Receptor 1a Following Activation of Heterologous G_q/11-Coupled Receptors

2004 • 47 citations

Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells

2005 • 43 citations

Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells

2000 • 41 citations

TRPC5 channels undergo changes in gating properties during the activation‐deactivation cycle

2008 • 41 citations

Spike Patterning by Ca²⁺-Dependent Regulation of a Muscarinic Cation Current in Entorhinal Cortex Layer II Neurons

2004 • 40 citations

Calmodulin Is a Phospholipase C-β Interacting Protein

2003 • 25 citations

Inhibition of TRPC5 Channels by Intracellular ATP

2007 • 22 citations

Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N′,N′-tetraacetic acid (BAPTA) and di-bromo BAPTA

2005 • 22 citations

Quantitative Aspects of Calcium Fluorimetry

2013 • 16 citations

Potentiating Actions of Lanthanum on ACh-Induced Cation Current in Guinea-Pig Ileal Smooth Muscle Cells.

1998 • 15 citations

Modulation of recombinant transient-receptor-potential-like (TRPL) channels by cytosolic Ca2+

2000 • 14 citations

Some quantitative aspects of calcium fluorimetry.

2005 • 12 citations