Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Environmental Contributions to the Obesity Epidemic

1998 • 2,243 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Valvular Heart Disease Associated with Fenfluramine–Phentermine

1997 • 1,595 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

From Lesions to Leptin

1999 • 1,165 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

1998 • 817 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

2000 • 795 citations

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

1993 • 719 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

1994 • 703 citations

Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat

2003 • 553 citations

Comparative localization of serotonin_{1A, 1C}, and ₂ receptor subtype mRNAs in rat brain

1995 • 549 citations

Activation of Central Melanocortin Pathways by Fenfluramine

2002 • 481 citations

Trends and Correlates of Class 3 Obesity in the United States From 1990 Through 2000

2002 • 469 citations

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999 • 439 citations

Serotonergic control of the organization of feeding and satiety

1995 • 419 citations

Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain

1999 • 411 citations

alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain.

1978 • 352 citations

Localization of 5-HT1B, 5-HT1Dα, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain

1994 • 343 citations

Neurobiology of an anorectic drug: Fenfluramine

1986 • 319 citations

Obesity, diabetes, and neoplasia in yellow A ^vy /‐ mice: ectopic expression of the agouti gene

1994 • 306 citations

Reduced satiating effect of d -fenfluramine in serotonin 5-HT 2C receptor mutant mice

1999 • 290 citations

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

1998 • 279 citations

The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*

2000 • 273 citations

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

1989 • 258 citations

Characterization of the Neuroanatomical Distribution of Agouti-Related Protein Immunoreactivity in the Rhesus Monkey and the Rat*

1999 • 226 citations

Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

1998 • 186 citations

Effect of intracerebroventricular α-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression

2000 • 149 citations

Serotoninergic endings on VIP-neurons in the suprachiasmatic nucleus and on ACTH-neurons in the arcuate nucleus of the rat hypothalamus. A combination of high resolution autoradiography and electron microscopic immunocytochemistry

1984 • 143 citations

Epilepsy and Obesity in Serotonin 5‐HT_2C Receptor Mutant Mice

1998 • 116 citations

Paraventricular hypothalamic α-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects

2001 • 112 citations

Molecular biology of serotonin (5‐HT) receptors

1994 • 98 citations

The Central Melanocortin System Can Directly Regulate Serum Insulin Levels

2000 • 96 citations

Characterization of the Neuroanatomical Distribution of Agouti-Related Protein Immunoreactivity in the Rhesus Monkey and the Rat

1999 • 85 citations

Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat

2000 • 70 citations

Reduction of Fat and Protein Intakes But Not Carbohydrate Intake Following Acute and Chronic Fluoxetine in Female Rats

1999 • 55 citations

Regulation of α-melanocyte-stimulating hormone release from superfused slices of rat hypothalamus by serotonin and the interaction of serotonin with the dopaminergic system inhibiting peptide release

1989 • 27 citations

Clinical studies with d-fenfluramine

1992 • 27 citations

Long-term administration of dexfenfluramine to genetically obese (ob/ob) and lean mice: Body weight and brain serotonin changes

1994 • 15 citations