Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

The rat nervous system

1985 • 3,774 citations

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

The paraventricular nucleus of the hypothalamus: Cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double‐labeling methods

1980 • 1,391 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1996 • 1,301 citations

The Leptin Receptor

1997 • 1,300 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

1984 • 1,274 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

From Lesions to Leptin

1999 • 1,165 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization

1992 • 1,052 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

1998 • 817 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems

1998 • 687 citations

PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine

1995 • 656 citations

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

1999 • 603 citations

Unraveling the central nervous system pathways underlying responses to leptin

1998 • 520 citations

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

1998 • 518 citations

Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus*

1997 • 488 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain

1998 • 432 citations

Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem

1997 • 428 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Evidence for two separate opiate peptide neuronal systems

1978 • 413 citations

Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei

1998 • 376 citations

Chemical characterization of leptin-activated neurons in the rat brain

2000 • 358 citations

Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

2001 • 333 citations

α-Melanocyte-Stimulating Hormone Is Contained in Nerve Terminals Innervating Thyrotropin-Releasing Hormone-Synthesizing Neurons in the Hypothalamic Paraventricular Nucleus and Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Gene Expression

2000 • 304 citations

Central Autonomic System

2014 • 278 citations

Further studies on the anatomical distribution of CART by in situ hybridization

1997 • 258 citations

The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)

1993 • 250 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.

1999 • 219 citations

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

1997 • 206 citations

Pathophysiological Significance of theObeseGene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats¹

1997 • 143 citations

The Arcuate Nucleus Is the Major Source for Neuropeptide Y-Innervation of Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus¹

1998 • 139 citations

Arcuate Nucleus Ablation Prevents Fasting-Induced Suppression of ProTRH mRNA in the Hypothalamic Paraventricular Nucleus

1998 • 138 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin

1998 • 133 citations

Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem

1997 • 95 citations

Pathophysiological Significance of the Obese Gene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats

1997 • 47 citations