Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

1995 • 627 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

1990 • 480 citations

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

1997 • 456 citations

Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation

1995 • 451 citations

Mitogenic Signaling via G Protein-Coupled Receptors

1996 • 425 citations

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

1994 • 387 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer.

1996 • 330 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

1995 • 288 citations

Role of Phosphoinositide 3-Kinase in Activation of Ras and Mitogen-Activated Protein Kinase by Epidermal Growth Factor

1999 • 280 citations

Effects of endothelins on signal transduction and proliferation in human melanocytes.

1991 • 269 citations

G Protein-coupled Receptors Mediate Two Functionally Distinct Pathways of Tyrosine Phosphorylation in Rat 1a Fibroblasts

1997 • 233 citations

Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src

1993 • 230 citations

The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity

1997 • 213 citations

Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.

1999 • 205 citations

Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines.

1991 • 198 citations

Stimulation of Phosphatidylinositol Hydrolysis, Diacylglycerol Release, and Gene Expression in Response to Endothelin, a Potent New Agonist for Fibroblasts and Smooth Muscle Cells

1989 • 166 citations

Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells

1992 • 163 citations

Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase

1997 • 160 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells.

1991 • 156 citations

Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125^FAK and paxillin induced by bombesin and endothelin

1994 • 138 citations

Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells.

1997 • 120 citations

The expression of EGF receptors, EGF-like factors and c-myc in ovarian and cervical carcinomas and their potential clinical significance.

1989 • 115 citations

The Seven-transmembrane-spanning Receptors for Endothelin and Thrombin Cause Proliferation of Airway Smooth Muscle Cells and Activation of the Extracellular Regulated Kinase and c-Jun NH2-terminal Kinase Groups of Mitogen-activated Protein Kinases

1996 • 111 citations

Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells.

1995 • 105 citations

Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes.

1994 • 95 citations

Epidermal Growth Factor Receptor mRNA Levels in Human Prostatic Tumors and Cell Lines

1990 • 94 citations

A novel ET_A antagonist (BQ‐123) inhibits endothelin‐1‐induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells

1992 • 92 citations

Structural Basis of G Protein Specificity of Human Endothelin Receptors

1995 • 86 citations

Coupling of ET_B Endothelin Receptor to Mitogen‐Activated Protein Kinase Stimulation and DNA Synthesis in Primary Cultures of Rat Astrocytes

1996 • 82 citations

Nuclear Signaling by Endothelin-1 Requires Src Protein-tyrosine Kinases

1996 • 77 citations

Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: the role of a wortmannin-sensitive signaling pathway.

1996 • 74 citations

Nuclear Signaling by Endothelin-1

1995 • 69 citations

Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs)

1993 • 68 citations

Expression of transforming growth factor alpha in human gliomas.

1990 • 62 citations

Endothelin-Dependent Actions in Cultured AT-1 Cardiac Myocytes

1996 • 59 citations

Human Melanoma Cells Express Functional Endothelin-1 Receptors

1994 • 57 citations

On the Mechanism of Cytosolic Phospholipase A2 Activation in CHO Cells Carrying Somatostatin Receptor: Wortmannin-Sensitive Pathway to Activate Mitogen-Activated Protein Kinase

1994 • 52 citations

Endothelin induces transcription of fos/jun family genes: a prominent role for calcium ion.

1992 • 52 citations

Endothelin-1 stimulates DNA synthesis and anchorage-independent growth of Rat-1 fibroblasts through a protein kinase C-dependent mechanism.

1990 • 50 citations

Activation of Multiple Mitogen-activated Protein Kinase Signal Transduction Pathways by the Endothelin B Receptor Requires the Cytoplasmic Tail

1996 • 50 citations

Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.

1991 • 41 citations

Bombesin and neuromedin B stimulate the activation of p42mapk and p74raf-1 via a protein kinase C-independent pathway in Rat-1 cells

1997 • 35 citations

Identification of the ETA Receptor Subtype That Mediates Endothelin-Induced Autocrine Proliferation of Normal Human Keratinocytes

1995 • 30 citations

Endothelin-Stimulated ERK Activation in Airway Smooth-Muscle Cells Requires Calcium Influx and Raf Activation

1999 • 28 citations

Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta.

1995 • 27 citations

Endothelin expression and responsiveness in human ovarian carcinoma cell lines

1997 • 26 citations

Human astrocytoma U138MG cells express predominantly type-A endothelin receptor

1996 • 17 citations

A selective endothelin ETA antagonist, BQ-123, inhibits125I-endothelin-1 (125I-ET-1) binding to human meningiomas and antagonizes ET-1-induced proliferation of meningioma cells

1994 • 13 citations