Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Renal and neuronal abnormalities in mice lacking GDNF

1996 • 1,260 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

Defects in enteric innervation and kidney development in mice lacking GDNF

1996 • 1,169 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Neural Crest Cells Contribute to Normal Aorticopulmonary Septation

1983 • 1,083 citations

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

1994 • 1,002 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

Function of the retinoic acid receptors (RARs) during development: (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants

1994 • 987 citations

Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos

1975 • 966 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Evolutionary families of peptidases

1993 • 897 citations

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

1994 • 886 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

1996 • 785 citations

Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny

1996 • 681 citations

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

1998 • 643 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

Neural Crest and Cardiovascular Patterning

1995 • 523 citations

DiGeorge syndrome: part of CATCH 22.

1993 • 510 citations

Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum

1995 • 496 citations

Vital dye analysis of cranial neural crest cell migration in the mouse embryo

1992 • 470 citations

Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome)

1996 • 449 citations

Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts

1996 • 409 citations

Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.

1995 • 393 citations

The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse.

1997 • 387 citations

Abundance of endothelin-3 in rat intestine, pituitary gland and brain

1989 • 346 citations

Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα ₁₃ Deficiency

1997 • 340 citations

Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches

1995 • 331 citations

Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp 2H) mutant

1997 • 313 citations

A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)

1996 • 303 citations

Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid

1973 • 287 citations

Neural crest cell migratory pathways in the trunk of the chick embryo

1987 • 284 citations

Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation.

1987 • 264 citations

Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

1996 • 245 citations

Patterning of Neural Crest Derivatives in the Avian Embryo: in Vivo and in Vitro Studies

1993 • 243 citations

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells

1997 • 196 citations

Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development

1996 • 159 citations

Initial migration and distribution of the cardiac neural crest in the avian embryo: An introduction to the concept of the circumpharyngeal crest

1991 • 128 citations

DiGeorge syndrome(s)

1972 • 119 citations

Genetic and epigenetic control in neural crest development

1994 • 111 citations

Lineage Diversification of the Neural Crest: In Vitro Investigations

1993 • 108 citations

Interruption of the aortic arch and coarctation of the aorta: Pathogenetic relations

1984 • 104 citations

Analysis of Neural Crest Cell Migration in Splotch Mice Using a Neural Crest-Specific LacZ Reporter

1997 • 99 citations

Temporospatial expression of the small HSP/αB-crystallin in cardiac and skeletal muscle during mouse development

1997 • 88 citations

Mapping the origin of the avian enteric nervous system with a retroviral marker

1994 • 86 citations

Cell origins and tissue boundaries during outflow tract development

1995 • 80 citations

From the Crest to the Periphery: Control of Pigment Cell Migration and Lineage Segregation

1993 • 78 citations

Some neuronal cell populations express human dopamine β-hydroxylase-lacZ transgenes transiently during embryonic development

1991 • 73 citations

A Modified Dopa Reaction for the Diagnosis and Investigation of Pigment Cells

1969 • 55 citations

The Splotch (Sp1H) and Splotch-delayed (Spd) alleles: differential phenotypic effects on neural crest and limb musculature

1993 • 53 citations

Sequence Analysis, Chromosomal Location, and Developmental Expression of the Mouse Preproendothelin-1 Gene

1996 • 49 citations

A sandwich-type enzyme immunoassay to detect immunoreactive big-endothelin-1 in plasma

1990 • 44 citations