Cellular Distribution of Endothelin-converting Enzyme-1 in Human Tissues

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

1995 • 1,077 citations

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

1994 • 1,002 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology.

1993 • 734 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Molecular biology and biochemistry of the endothelins

1989 • 620 citations

Endothelin is a potent mitogen for rat vascular smooth muscle cells

1989 • 509 citations

Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum

1995 • 496 citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

1998 • 488 citations

Endothelium-derived contracting factors.

1992 • 395 citations

Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX

1997 • 395 citations

Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.

1995 • 393 citations

Molecular and cellular mechanism of endothelin regulation. Implications for vascular function.

1991 • 391 citations

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.

1997 • 283 citations

Endothelin‐converting enzymes

1992 • 223 citations

Molecular cloning and primary structure of Kell blood group protein.

1991 • 218 citations

Organization of the Gene Encoding the Human Endothelin-converting Enzyme (ECE-1)

1995 • 216 citations

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)

1988 • 207 citations

Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations

1997 • 204 citations

Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1)

1994 • 200 citations

Conversion of Big Endothelin-1 to 21-Residue Endothelin-1 Is Essential for Expression of Full Vasoconstrictor Activity

1989 • 184 citations

Possible Role of Endothelin in Endothelial Regulation of Vascular Tone

1995 • 182 citations

Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.

1991 • 165 citations

Purification and characterization of endothelin-converting enzyme from rat lung.

1993 • 154 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme

1990 • 142 citations

Enhancement of mRNA in situ hybridization signal by microwave heating.

1995 • 140 citations

Cloning and Functional Expression of Human Endothelin-Converting Enzyme cDNA

1995 • 132 citations

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo

1989 • 126 citations

Endothelin-Converting Enzyme Expression in the Rat Vascular Injury Model and Human Coronary Atherosclerosis

1997 • 122 citations

Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells

1995 • 114 citations

Novel activity of endothelin-converting enzyme: hydrolysis of bradykinin

1997 • 106 citations

cDNA Cloning and Expression of Bovine Endothelin Converting Enzyme

1994 • 75 citations

Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage

1997 • 67 citations

Endothelins Stimulate Deoxyribonucleic Acid Synthesis and Cell Proliferation in Rat Adrenal Zona Glomerulosa, Acting through an Endothelin A Receptor Coupled with Protein Kinase C- and Tyrosine Kinase-Dependent Signaling Pathways

1997 • 56 citations

Expression of the Endothelin-Converting Enzyme Gene in Human Tissues

1995 • 46 citations

Differential distribution of endothelin peptides and receptors in human adrenal gland

1996 • 43 citations

Endothelins as regulators of growth and function in endocrine tissues

1993 • 43 citations

Endothelin‐1 and Its Receptors in Human Testis

1995 • 43 citations

Construction, expression and characterization of a soluble form of human endothelin‐converting‐enzyme‐1

1997 • 37 citations

Expression of endothelin-1 gene and protein in human granulosa cells.

1996 • 37 citations

Gene Expression of Endothelin-1, Endothelin-Converting Enzyme-1, and Endothelin Receptors in Human Epididymis¹

1997 • 34 citations

Identification, Characterization, and Biological Activity of Endothelin Receptors in Human Ovary¹

1997 • 31 citations

Neural Crest Development: Do developing enteric neurons need endothelins?

1995 • 24 citations

IN VITRO AUTORADIOGRAPHIC DEMONSTRATION OF ENDOTHELIN-1 BINDING SITES IN THE HUMAN ADRENAL CORTEX

1994 • 17 citations

Immunohistochemical Double Staining of Microwave Enhanced and Nonenhanced Nuclear and Cytoplasmic Antigens

1997 • 9 citations

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